Von Willebrand factor collagen-binding capacity predicts in-hospital mortality in COVID-19 patients: insight from VWF/ADAMTS13 ratio imbalance폰 빌레브란트 인자 콜라겐 결합 능력은 COVID-19 환자의 병원 내 사망률을 예측합니다: VWF/ADAMTS13 비율 불균형으로부터의 통찰력Article Published on 2021-08-012022-09-11 Journal: Angiogenesis [Category] SARS, 바이오마커, [키워드] 48 hour 48 hours 95% CI ADAMTS13 adjusted Admission Analysis AUC balance best Biomarker BMI C-reactive protein collagen Collagen-binding COVID-19 COVID-19 severity Critical cut-off D-dimer levels described enrolled hallmark hazard Hospital mortality hospitalized COVID-19 patient in-hospital mortality IQR Kaplan-Meier estimator median Microthrombosis molecular weight Mortality Multimers Patient Plasma level Plasma levels predict Predictive ROC Curve shown significantly subsequent Trigger von Willebrand factor vWF was increased were measured [DOI] 10.1007/s10456-021-09789-3 PMC 바로가기 [Article Type] Article
Effect of Inadequate Empiric Antibacterial Therapy on Hospital Outcomes in SARS-CoV-2-Positive and -Negative US Patients With a Positive Bacterial Culture: A Multicenter Evaluation From March to November 2020Major Articles Published on 2021-06-262022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] 48 hour 95% CI active against acute respiratory syndrome Adequate adequate therapy Antibacterial antibacterial therapy Antibiotic therapy Antimicrobial therapy Antimicrobials Bacteria Bacterial bacterial cultures Bacterial infection bacterial pathogen coronavirus coronavirus disease COVID-19 Culture cultures defined Effect empiric therapy evaluate evaluated help hospital in-hospital mortality Inadequate Increased inpatient admission insight intensive care linear mixed model LOS management Mortality multicenter Odds ratio outcome outcomes pandemic pathogen Patient patients positive remained Result Retrospective study SARS-CoV-2 therapeutic therapy [DOI] 10.1093/ofid/ofab232 PMC 바로가기 [Article Type] Major Articles
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and ThromboembolismImmunology Published on 2021-06-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 48 hour ACE2 ANPEP Apoptosis Autoimmune disease cancers cardiovascular comorbidity cardiovascular disease CEACAM1 cell death changes in complexes contribute controls coronavirus Coronavirus infection Coronaviruses COVID-19 CSF1 CSF3 CVD Cytokine storms DAMP DAMPs dataset death DPP4 Endothelial cell enzyme Epigenetic ER stress examined Express expressed expression facilitate Factor Ferroptosis hours post-infection Human hyperlipidemia IL6 Immunity Inflammation innate immune innate immune responses LPS majority marker MERS-CoV Microarray mitochondrial mitotic modulated monocyte Myelopoiesis Nrf2 nucleic acid oxidative phosphorylation PAMP Proinflammatory cytokine Proinflammatory response protein complex pyroptosis receptor regulate ROS stimulated Stimulation storm Stress subsequent Thromboembolism thrombosis TMPRSS2 TNFα trained immunity transcriptomic upregulated upregulation Viremia virus entry [DOI] 10.3389/fimmu.2021.653110 PMC 바로가기 [Article Type] Immunology
Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics장기 실패, 항 바이러스 치료 및 인구 통계 학적 특성에 중점을 둔 급성 코비드 -19 감염에서 면역 혈청 마커의 시간적 변화에 대한 편견없는 분석Immunology Published on 2021-06-112022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] 48 hour 48 hours Admission age analyzed Biomarker Biomarkers CCL23 CD28 change chemokine chemokines collected condition convalescent plasma correlated Course COVID-19 COVID-19 admission Deceased decorin demographic demographics demonstrated elevated failure GzmB heterogeneity Hydroxychloroquine ICU identification IL-15 IL-18 immune immunological increased expression individual kidney Kidney failure lack LAG3 LAMP3 ligands Longitudinal studies MCP MCP-1 MCP-3 monocyte Mortality Older age pathology pleiotrophin positively correlated programmed death Protein proteomics remdesavir Remdesivir respiratory serum serum levels Serum Marker Seven severity of COVID-19 steroid Steroids target Temporal the disease therapeutic TNFRSF21 Variation VEGF with COVID-19 [DOI] 10.3389/fimmu.2021.650465 PMC 바로가기 [Article Type] Immunology
Study protocol of the Edinburgh and Lothian Virus Intervention Study in Kids: a randomised controlled trial of hypertonic saline nose drops in children with upper respiratory tract infections (ELVIS Kids)어린이에 대한 에딘버러 및 로시안 바이러스 중재 연구의 연구 프로토콜: 상부 호흡기 감염이 있는 어린이의 고장성 식염수 점비제에 대한 무작위 대조 시험(ELVIS Kids)Article Published on 2021-05-052022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 24 hour 24 hours 48 hour 48 hours age All participant All participants approved asked Asymptomatic board Care Child child health children chloride clinical Community community child health Complete Contact control arm Controlled trial determine Edinburgh Ethics events Health hypertonic hypertonic saline immunisation Infection Infectious disease Intervention intervention arm Local media nasal swab National Health Service neonatology nose drop nose drops nostril office Open-label paediatric infectious disease & Participation partnership peer-reviewed primary care protocol provided questionnaire randomised randomised controlled trial recruited recruitment registration number Research Research Ethics satisfaction questionnaire service Sodium chloride standard care Symptom symptomatic university upper respiratory tract upper respiratory tract infection URTI URTI symptom URTI symptoms Virology website West wheeze [DOI] 10.1136/bmjopen-2021-049964 PMC 바로가기 [Article Type] Article
Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical TrialRandomized Controlled Trial Published on 2021-05-042022-10-05 Journal: JAMA [Category] 임상, [키워드] 28-day mortality 48 hour absolute difference applied assigned clinical COVID-19 Day determine Effect Endotracheal intubation Enrollment Follow-up fraction Free High-flow nasal oxygen High-flow oxygen hospital hypoxemic ICU ICUs in-hospital mortality initial intensive care unit Invasive mechanical ventilation IQR Italy mean difference median median age moderate Mortality nasal oxygen no significant difference Noninvasive ventilation outcome outcomes oxygen participant Patient patients with COVID-19 Positive end-expiratory pressure Primary outcome proportion randomization Randomized randomized clinical trial Randomly receive reported required Research respiratory Respiratory failure Respiratory Support secondary secondary outcome severe hypoxemia significantly higher significantly lower statistically significant study enrollment Support Treatment Trial women [DOI] 10.1001/jama.2021.4682 PMC 바로가기 [Article Type] Randomized Controlled Trial
[Management of elective surgical activity in a tertiary hospital during the SARS-CoV-2 pandemic][SARS-CoV-2 대유행 기간 동안 상급 병원의 선택적 외과 활동 관리]Article Published on 2021-05-012022-09-11 Journal: Journal of healthcare quality research [Category] Coronavirus, SARS, 치료기술, [키워드] 48 hour 48 hours addition alarm Area Asymptomatic Cirugía coronavirus Coronavirus infection COVID-19 creation decrease Early detection English evaluated expressing Health status hospital Hospitalization Intervention minimum nasopharyngeal occupational occupational health Operating room Pandemia pandemic pathology PCR pocas professional provided recommendation risk SARS-CoV-2 SARS-CoV-2 pandemic Spanish Streamline surgery surgical telephone the patient the SARS-CoV-2 thought undergo was reduced [DOI] 10.1016/j.jhqr.2021.01.002 PMC 바로가기 [Article Type] Article
What Proportion of Patients with Bone and Soft Tissue Tumors Contracted Coronavirus-19 and Died From Surgical Procedures During the Initial Period of the COVID-19 Pandemic? Results From the Multicenter British Orthopaedic Oncology Society Observational StudyObservational Study Published on 2021-05-012022-10-05 Journal: Clinical orthopaedics and related research [Category] SARS, 임상, [키워드] 48 hour addition adjuvant therapy Admission age agency analyzed association Asymptomatic benefit bone Cancer Cancer center cancer treatment Care Chemotherapy clinician Complication contracting the virus Coronavirus 2019 COVID-19 COVID-19 in patient COVID-19-related complications detrimental eight England Factor FIVE Follow-up Future help hospital Hospital stay identify Increased increased mortality increased risk initial knowledge Level likelihood lower risk management mandatory measure median men Mortality Musculoskeletal National National Health Service Odds ratio oncology outcome outcomes pandemic Patient patients died PCR testing performed Period potential risk Primary outcome procedure Radiation reduce Result retrospective risk secondary outcome Society Soft surgeon surgical Surgical Procedure susceptibility tested the median therapeutic therapy tissue treated Treatment Tumor undergo United Kingdom were used [DOI] 10.1097/CORR.0000000000001568 PMC 바로가기 [Article Type] Observational Study
Evaluation of SARS-CoV-2 in Tears of Patients with Moderate to Severe COVID-19중등도에서 중증 COVID-19 환자의 눈물에서 SARS-CoV-2 평가Article Published on 2021-04-012022-09-11 Journal: Ophthalmology [Category] SARS, 치료기술, [키워드] 48 hour 48 hours amplification curve Analysis Chain Reaction collected Comorbidities conjunctival Conjunctival swab coronavirus disease Coronavirus disease 2019 COVID-19 cross-sectional study Ct value Ct values cycle threshold E gene enrolled eye Frame gold gold standard group laboratory confirmation manifestation median value moderate moderate disease moderate to severe nasopharyngeal Nasopharyngeal swab ocular Open reading frame outcome Patient patients patients with moderate polymerase chain polymerase chain reaction positive positive result positive RT-PCR profiles real-time RT-PCR reverse-transcriptase polymerase chain reaction RNA-dependent RNA polymerase RT-PCR analysis RT-PCR assay Sample SARS-CoV-2 SARS-CoV-2 RNA severe coronavirus disease severe COVID-19 severe disease significantly higher specimen statistically significant Swab Symptomatology systemic symptoms Tear tears threshold transported Viral load Viral transmission viral transport media was determined [DOI] 10.1016/j.ophtha.2020.08.029 PMC 바로가기 [Article Type] Article
Early antiviral treatment in outpatients with COVID-19 (FLARE): a structured summary of a study protocol for a randomised controlled trialCOVID-19(FLARE) 외래 환자의 조기 항바이러스 치료: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-03-082022-09-01 Journal: Trials [Category] SARS, 임상, 진단, 치료기술, 치료제, [키워드] 24 hours 48 hour 48 hours absence admitted to ICU aetiology age ALT Analysis Anosmia anticipated antiviral therapy Antiviral treatment antivirals Appendix Arm arrhythmia AST Asthma Asymptomatic Autoimmune blinded to treatment Blinding blood sample BMI Breastfeeding childbearing potential Cholangitis chronic chronic hepatitis Chronic kidney disease chronic liver disease chronic respiratory disease cirrhosis clinical condition collected combination therapy Comorbidity concealed Concomitant concomitant medications conducted COPD coryza cough COVID-19 COVID-19 disease COVID-19 vaccine criteria current Date Day decrease defined Deleterious detectable diabetes died disease dissemination dose double-blind Duration early treatment effective EGFR element enrolled enrolment Ethnicity examined exclusion criteria factorial design Favipiravir female female participant Fever followed by Free Gender headache heart disease Hepatitis hepatotoxicity HIV infection hospital hospitalisation hypersensitivity hypertension in viral include inclusion criteria ingredient investigator investigators Ischaemic heart disease Kidney disease liver Liver disease London Lopinavir Lopinavir/ritonavir malaise male participant male participants measure medication Mutation myalgia Myocardial infarction no symptom non-hospitalised not limited number obesity objective observational studies observational study oral outcome Outpatient outpatients participant Participants partner percentage pharmacokinetic phase IIa Placebo placebo-controlled placebo-controlled trial positive presence or absence Primary outcome Proportion of participant Protease inhibitor protocol randomised randomised controlled trial Rate Registered Registration respiratory Respiratory disease risk Ritonavir Safety Saliva saliva samples Sample size SARS-CoV-2 secondary Secondary outcomes Shortness of breath smoker smoking smoking status Stage status steatohepatitis Stool Study protocol supplementary material Symptom symptom onset symptomatic tested therapy Toxicity Treatment treatment allocation Trial trial medication Trial registration undetectable United Kingdom upper respiratory tract vaccine trial valvular valvular heart disease Viral Viral load website with COVID-19 [DOI] 10.1186/s13063-021-05139-2 PMC 바로가기 [Article Type] Letter