A multimodal deep learning-based drug repurposing approach for treatment of COVID-19COVID-19의 치료를위한 멀티 모달 딥 러닝 기반 약물 재검사 접근법Article Published on 2021-08-012022-08-31 Journal: Molecular diversity [Category] 신약개발, [키워드] applied approach chemical structures Cluster computational method COVID-19 deep deep learning demonstrated differentially expressed gene Differentially expressed genes distribution drug Drug repurposing drugs dysregulated feature Features information machine medication Medicine Medicines modality Multimodal data fusion perturbations Probability probability distribution problem RBM Restricted Restricted Boltzmann machine. resulting Side effects small molecule Small molecules source code Structure therapeutic treat Treatment was used were used [DOI] 10.1007/s11030-020-10144-9 PMC 바로가기 [Article Type] Article
Non-RBM Mutations Impaired SARS-CoV-2 Spike Protein Regulated to the ACE2 Receptor Based on Molecular Dynamic SimulationMolecular Biosciences Published on 2021-07-272022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 ACE2 receptor ACE2-RBD binding addition angiotensin-converting enzyme 2 bind binding binding free energy change changes conducted coronavirus Deterioration domain dynamic electrostatic interaction experiment higher affinity host cell hydrophobic interactions Impaired Infection interact Interaction looser molecular dynamic simulation molecular dynamics mutant Mutation mutations non-RBM mutations Novel coronavirus pathogenicity performed polar positive Protein random RBD RBM RBM region receptor Receptor binding domain receptor-binding motif Region Research residue SARS-CoV-2 SARS-CoV-2 mutation selected shown significantly Simulation spike Spike protein the epidemic the RBD V367F weakened wild-type [DOI] 10.3389/fmolb.2021.614443 PMC 바로가기 [Article Type] Molecular Biosciences
A Fungal Defensin Targets the SARS−CoV−2 Spike Receptor−Binding DomainArticle Published on 2021-07-122022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] ACE2 antiviral agent antiviral drug approaches binding affinity Combination coronavirus coronavirus 2 defensin dermatophytic fungus domain drugs elicited enzyme exhibited fungal high affinity highlight host cell human ACE2 hydrogen bond network hydrophobic interacting residue Interaction interactions micasin Microsporum canis motif Point mutation predicted Prevent Protein RBD RBD binder RBM resource respiratory SARS−CoV−2 significantly spike target viral entry [DOI] 10.3390/jof7070553 PMC 바로가기 [Article Type] Article
Possible inhibition of GM-CSF production by SARS-CoV-2 spike-based vaccinesSARS-CoV-2 스파이크 기반 백신에 의한 GM-CSF 생성 억제 가능성Perspective Published on 2021-05-222022-09-12 Journal: Molecular Medicine [Category] SARS, 진단, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory effect antibodies antibody boost caused coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression elicit Evidence GM-CSF host receptor inhibiting Interaction Like mRNA pandemic protective antibodies Protective antibody RBM receptor-binding motif SARS-CoV SARS-CoV-2 SARS-like coronavirus Spike protein spike protein of SARS-CoV-2 Spike-based vaccine spike-based vaccines suggested the spike protein Vaccine viral entry [DOI] 10.1186/s10020-021-00313-3 PMC 바로가기 [Article Type] Perspective
Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes신규 결합 에피토프를 갖는 SARS-CoV-2 중화 항체의 구조적 기초Research Article Published on 2021-05-072022-08-13 Journal: PLoS Biology [Category] Biochemistry, SARS, 진단, [키워드] ACE2 receptor acute respiratory syndrome coronavirus Ad5-hACE2 Ad5-hACE2 transduction mouse model angiotensin antibodies antibody antiviral efficiency applied binding binding epitope caused characterized coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 domain Economy epitope Epitopes global public health H2L2 platform H2L2 transgenic mice hACE2 help High-resolution X-ray crystallography structures human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human immunoglobulin human immunoglobulin variable regions humanized NAb identify immunize Immunoglobulin injection mAb mAb-related therapeutic intervention mAb-related therapeutic interventions monoclonal antibody mouse model NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody novel non-blocking epitope pandemic platform PR1077 PR953 PR961 Prophylactic provide provided RBD RBM receptor-binding motif recombinant vaccines regions respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein spike receptor-binding domain Structural analysis Structure subsequent tested the antibody the SARS-CoV-2 the spike protein therapeutic interventions therapy transgenic mice treatment groups variable regions X-ray crystallography [DOI] 10.1371/journal.pbio.3001209 PMC 바로가기 [Article Type] Research Article
Risk-Based Monitoring in Clinical Trials: Past, Present, and Future임상 시험의 위험 기반 모니터링: 과거, 현재 및 미래Analytical Report Published on 2021-04-292022-09-10 Journal: Therapeutic innovation & regulatory science [Category] MERS, SARS, 치료기술, [키워드] ACRO adoption approach clinical Clinical research clinical trial collected component conducted COVID-19 pandemic data integrity deviation Effectiveness Future greater highlighting implementation KRIs monitoring organization pandemic patient safety powerful tool present promote protocol ranged RBM reduced reduction in risk site monitoring Support switching Trial trials [DOI] 10.1007/s43441-021-00295-8 PMC 바로가기 [Article Type] Analytical Report
AP205 VLPs Based on Dimerized Capsid Proteins Accommodate RBM Domain of SARS-CoV-2 and Serve as an Attractive Vaccine CandidateArticle Published on 2021-04-192022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activities aggregate aggregates Analysis antibody AP205-VLPs C terminus candidate capsid caused Convalescent patients COVID-19 denatured dimerized disease displaying domain E. coli expressed fused generate Health humoral immune response IgG antibody immunization immunized mice Impact insoluble Microscopy neutralize neutralizing antibody pandemic produced Proteins RB motif RBD RBM Receptor binding domain receptor binding motif recognizing resulting SARS-CoV-2 Spike protein urea vaccination vaccine candidate virus-like particles VLP were expressed [DOI] 10.3390/vaccines9040403 PMC 바로가기 [Article Type] Article
Monoclonal antibodies capable of binding SARS‐CoV‐2 spike protein receptor‐binding motif specifically prevent GM‐CSF inductionConcise Report Published on 2021-03-242022-10-29 Journal: Journal of leukocyte biology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Affect antibody binding blocked boost caused coronavirus COVID‐19 cultures cytokine antibody array disease effort enzyme GM‐CSF GM‐CSF Host human ACE2 infections Inflammatory response inhibit inhibited Interaction Like mAb mAbs Macrophage monoclonal antibody mononuclear cell mononuclear cells motif murine pandemic Peripheral blood Prevent Protective antibody protective mechanism Protein purified RBM SARS‐CoV‐2 SARS‐CoV‐2 spike secretion Spike protein suggested surface plasmon resonance the spike protein Vaccine Vaccines viral entry viral spike [DOI] 10.1002/JLB.3COVCRA0920-628RR PMC 바로가기 [Article Type] Concise Report
Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike proteinResearch Article Published on 2021-03-192022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] ACE ACE2 Analysis antibodies antibody Belgium binding binding domain circulating clades Comparative genomics Consensus country COVID-19 D614G docking enzyme expected EY6A Fatality rate France Genome higher affinity higher fatality rate higher infectivity India infection rates Interaction isolate isolates Italy lowest Molecular dynamics simulation mortality rate Mutation N439K Neutralizing antibodies neutralizing monoclonal antibodies novel coronavirus SARS-CoV-2 pandemic Pathogenesis Prevalence prevalent RBM reactivity receptor Receptor binding domain receptor binding motif reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 virus Spike protein Support USA variant virulence Wuhan-1 [DOI] 10.1016/j.heliyon.2021.e06564 PMC 바로가기 [Article Type] Research Article
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity순환하는 SARS-CoV-2 스파이크 N439K 변이체는 항체 매개 면역을 피하면서 체력을 유지합니다Article Published on 2021-03-042022-09-11 Journal: Cell [Category] Fulltext, SARS, 변종, 진단, [키워드] antibody Antibody therapeutics binding affinity Clinical outcome consequence COVID-19 disease drug Efficacy Emergency use epidemiological evade FDA fitness food hACE2 hACE2 receptor highlighting Immunity immunodominant increase Infection Lineage mAb mAbs maintain molecular monoclonal antibody escape mutate Mutation N439K neutralizing monoclonal antibodies neutralizing monoclonal antibody polyclonal polyclonal antibody polyclonal sera prevalent protein structure RBM receptor binding motif receptor-binding motif reduce reducing Replication response responses S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike spike Surveillance the SARS-CoV-2 Therapeutics US Food and Drug Administration Usage Vaccine variable region variant Viral viral fitness virulence virus viruses wild type wild-type [DOI] 10.1016/j.cell.2021.01.037 PMC 바로가기 [Article Type] Article