RESIC: A Tool for Comprehensive Adenosine to Inosine RNA Editing Site Identification and ClassificationGenetics Published on 2021-07-232022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] ADAR adenosine approach can be used carried changes in classification Comprehensive computational approach COVID-19 disease dataset datasets DNA double-stranded RNA Enzymes Epitranscriptome exclusion genomic human cell lines hyper-editing identification identify Inosine interferon organism overlapping phenotype polymorphism prevalent provide regions reliability RNA RNA sequencing RNA-sequencing SARS-CoV-2 SARS-COV-2 infection sequencing data Site SNP tested utility [DOI] 10.3389/fgene.2021.686851 PMC 바로가기 [Article Type] Genetics
Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19GS-441524의 세포 흡수 및 세포 내 인산화 : Covid-19에 대한 효과에 대한 영향Review Published on 2021-07-142022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] adenosine adenosine analogs adenosine kinase adenosine levels adenosine transporters alveolar cell alveolar cells alveoli anticancer Antiviral approval cellular cellular uptake clinical effectiveness COVID-19 Critical decrease decreased expression disease effective Effectiveness epithelial cell epithelial cells expressed expression Extracellular GS-441524 healthy hypoxia illnesses Increases increases in Inflammation Intracellular knowledge lead limit Lungs monophosphate nucleoside occur outcome parent nucleoside pharmacokinetic Phosphorylation pneumocyte Pneumocytes protein expression reduced Remdesivir SARS-CoV-2 severe inflammation therapeutic tissue tissues Treatment treatment of COVID-19 triphosphate uptake [DOI] 10.3390/v13071369 PMC 바로가기 [Article Type] Review
Genomic epidemiology of SARS-CoV-2 in the UAE reveals novel virus mutation, patterns of co-infection and tissue specific host immune responseUAE에서 SARS-COV-2의 게놈 역학은 새로운 바이러스 돌연변이, 공동 감염 패턴 및 조직 특이 적 숙주 면역 반응을 나타낸다.Article Published on 2021-07-072022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, [키워드] ADAR adenosine APOBEC APOBEC4 Bronchoalveolar lavage fluid clade Co-infection collected conducted COVID-19 epidemic cytosine defined distribution enrichment epidemiological Epidemiology Evolution expression FIVE gene families gene family Genetic variant genetics genomic Host Host immune response host response human-to-human transmission infected patients Infectious diseases innate immune Inosine Interaction knowledge Local molecular Mutation Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharynx pattern provide reported reveal SARS-CoV-2 SARS-CoV-2 evolution Sequencing subclade the SARS-CoV-2 tissue specific Transmission United Arab Emirates upregulation uracil Viral virus was related [DOI] 10.1038/s41598-021-92851-3 PMC 바로가기 [Article Type] Article
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells인간 폐 세포에서 Remdesivir 활성화에 관여하는 주요 대사 효소Antiviral Agents Published on 2021-06-142022-09-10 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] adenosine Alanine Antiviral antiviral activity biochemical bioinformatic analysis carboxylesterase carboxylesterase 1 CatA catalytic cathepsin A Cell culture cells cellular CES1 COVID-19 Critical data sets demonstrated Effect enzyme Enzymes GS-5734 HINT1 histidine Human human lung tissue hydrolyzed Hypothesis inhibitor involved lung lung cells metabolic metabolic pathway metabolism monophosphate mRNA mRNA expression nucleoside nucleoside triphosphate nucleotide nucleotide analogs nucleotide-binding protein 1 pathway phosphorylated Phosphorylation polymerases prodrug activation Protein quantification RDV Remdesivir respiratory respiratory viral infection RNA-Seq SARS-CoV-2 selective sequence single-cell Support target cell target cells tissue treat Treatment triphosphate turn unique Veklury Viral Viral RNA [DOI] 10.1128/AAC.00602-21 PMC 바로가기 [Article Type] Antiviral Agents
Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART—a UK, multicentre, observational studyCOVID-19로부터 심근 침범 및 회복에 대한 인구통계학적, 다중 이환율 및 유전적 영향: COVID-HEART의 프로토콜 설계 - 영국, 다기관, 관찰 연구Study Protocol Published on 2021-06-102022-09-10 Journal: Journal of Cardiovascular Magnetic Resonance [Category] MERS, SARS, 바이오마커, 임상, [키워드] 6MWT adenosine adverse outcomes age assessment assessments Baseline assessment cardiovascular disease Cardiovascular Magnetic Resonance characterisation clinical Clinical outcome Clinical significance Comorbidities Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient demographic demographics dependent on discharged ECG electrocardiogram elevated Ethnicity evaluate Factors functional functional capacity gadolinium Genetic genetic factors genetics In-hospital include increasingly ISRCTN life longitudinal cohort study measure Mortality multicentre Myocardial Myocardial infarction Myocardial inflammation myocardial injury myocardial involvement Myocardial repair myocarditis Myopericarditis pathophysiology Patient patients protocol Quality of life reported respiratory Respiratory illness risk factor selected serum biomarker serum biomarkers Sex Stress T1/T2 troponin [DOI] 10.1186/s12968-021-00752-1 PMC 바로가기 [Article Type] Study Protocol
Piece of the puzzle: Remdesivir disassembles the multimeric SARS-CoV-2 RNA-dependent RNA polymerase complex퍼즐 조각: Remdesivir는 다량체 SARS-CoV-2 RNA 의존성 RNA 중합효소 복합체를 분해합니다Article Published on 2021-06-012022-09-11 Journal: Cell biochemistry and biophysics [Category] SARS, 치료제, [키워드] Accelerated molecular dynamics simulation adenosine ATP binding complex computational simulations contribute Detachment disrupt domain domains finding flexible followed by global mortality higher affinity hosts Human mechanism molecular molecular dynamics Molecular dynamics simulation non-structural proteins Nsp7 NSP8 nucleotide PALM Perturbation piece RdRP Remdesivir Replication replicative reported RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-like coronavirus significantly Spread structure-based design subunit the SARS-CoV-2 underlie Viral RNA virus [DOI] 10.1007/s12013-021-00977-y PMC 바로가기 [Article Type] Article
Possible Beneficial Actions of Caffeine in SARS-CoV-2SARS-CoV-2에서 가능한 카페인의 유익한 작용Review Published on 2021-05-222022-08-31 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] Action addition adenosine airway airway smooth muscle angiotensin Angiotensin-converting enzyme Anti-inflammatory antiviral activity Awareness caffeine chymotrypsin complex Consumption COVID-19 COVID-19 pandemic domain drug Effect effective fatigue host cell host cells immunomodulator immunomodulatory effects IMPROVE in silico in vitro in vivo models increase Infection inhibiting inhibitor mechanism molecular molecular docking molecular dynamics Proteases receptor receptor antagonist Receptor-binding domain reduce reduce viral replication required SARS-CoV-2 smooth muscle specific treatment suggested Treatment Viral viral replication wakefulness [DOI] 10.3390/ijms22115460 PMC 바로가기 [Article Type] Review
Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance심혈관 자기 공명으로 평가한 회복된 트로포닌 양성 COVID-19 환자의 심근 손상 패턴Article Published on 2021-05-142022-09-11 Journal: European heart journal [Category] Fulltext, SARS, 치료기술, [키워드] adenosine cardiovascular Cardiovascular Magnetic Resonance change clinically Control convalescence convalescent coronary disease COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients de novo diffuse discharged disease Ejection fraction Evidence evidence of fibrosis functional gadolinium had no heart disease hospital Hospital admission hospitalized COVID-19 patients indicated Infarction Inflammation Injury Ischaemic heart disease left less LV dysfunction male median Myocardial Myocardial infarction myocardial injury Myocardial oedema myocarditis Myocardium no evidence of oedema past history pathology Patient patients pattern proportion quarter Recovered COVID-19 patients SARS-CoV-2 scar Severe COVID-19 Infection silent Stress troponin underlying aetiology Undetermined ventilatory ventilatory support ventricular [DOI] 10.1093/eurheartj/ehab075 PMC 바로가기 [Article Type] Article
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infectionMETTL3은 SARS-CoV-2 감염 동안 바이러스 m6A RNA 변형 및 숙주 세포 선천성 면역 반응을 조절합니다Article Published on 2021-05-112022-09-11 Journal: Cell Reports [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adenosine binding clade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 treatment decrease disease downstream ENhance expression Gene Expression Host host cell host genes Host immune response host innate immunity increase Inflammation Inflammatory inflammatory gene inflammatory genes innate immune innate immune response Innate immunity m(6)A RNA modification. methyltransferase METTL3 Modification molecular mechanism Patient physiological reduced reduction in regulate RIG-I RNA RNA modification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe coronavirus disease signaling pathway the SARS-CoV-2 the SARS-CoV-2 virus Treatment viral genome Viral RNA widespread [DOI] 10.1016/j.celrep.2021.109091 PMC 바로가기 [Article Type] Article
Cystic fibrosis improves COVID-19 survival and provides clues for treatment of SARS-CoV-2Original Article Published on 2021-05-102022-10-29 Journal: Purinergic Signalling [Category] COVID-19, SARS, [키워드] Abraham adenosine adenosine triphosphate ATP benefit biochemical Blood cancer patient CF CFTR clinically coronavirus COVID-19 cystic fibrosis Cytokine storm elevated evidenced fibrosis General population homozygous Hypothesis IMPROVE improvement individual Medicine Nature Pannexin Patient plasma provide Purinergic Quality of life SARS-CoV-2 solid tumor subsequent survival systemic Treatment [DOI] 10.1007/s11302-021-09771-0 PMC 바로가기 [Article Type] Original Article