COVID-19 Vaccination Effectiveness Against Infection or Death in a National U.S. Health Care System : A Target Trial Emulation Study미국 국립 의료 시스템의 감염 또는 사망에 대한 COVID-19 예방 접종 효과 : 표적 시험 에뮬레이션 연구Article Published on 2022-03-012022-09-11 Journal: Annals of internal medicine [Category] SARS, 변종, [키워드] 1:1 95% CI advanced age Affair Against black both groups Care Characteristics Comorbidity Control controls COVID-19 COVID-19 vaccine COVID-19 vaccines death defined Department determine distribution dose Effectiveness effort example Follow-up group Health Health care Health care system Hispanic in both groups increasing age Infection lack male Messenger RNA Moderna pandemic Pfizer-BioNTech Population Racial receiving reported SARS-COV-2 infection SARS-CoV-2 variants System target Trial vaccination vaccine dose veteran [DOI] 10.7326/M21-3256 PMC 바로가기 [Article Type] Article
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Pandemic: Are Africa’s Prevalence and Mortality Rates Relatively Low?Review Article Published on 2022-02-262022-10-28 Journal: Advances in Virology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome advanced age Affect African allelic variants BCG binding complex condition conditions Consequences coronavirus disease Coronavirus-2 COVID-19 deficiency disease disease severity Epidemiology exacerbate expression Factor Frequency Genetic predisposition genetic susceptibility genetics global pandemic Health host cell host cell receptor host tissue hypothese Immunity include Infection infection risk inhibitor Interaction involved lack less lung Lungs majority malaria Mortality mortality rate Occurrence other organ outcome pandemic Pathogenesis pathology Population populations Prevalence protease Protein Rate reported respiratory risk factor SARS-CoV-2 Spread structural protein subsequent subunit the disease thought TMPRSS2 vaccination virus [DOI] 10.1155/2022/3387784 PMC 바로가기 [Article Type] Review Article
“H” is not for hydroxychloroquine—“H” is for heparin: lack of efficacy of hydroxychloroquine and the role of heparin in COVID-19—preliminary data of a prospective and interventional study from Brazil"H"는 하이드 록시 클로로 퀴인을위한 것이 아닙니다. "H"는 헤파린을위한 것입니다 : 하이드 록시 클로로 퀴인의 효능 부족과 COVID-19에서 헤파린의 역할-브라질의 전향 적 및 중재 연구의 예비 데이터Research Published on 2022-02-042022-09-10 Journal: BMC Infectious Diseases [Category] COVID19(2023년), Fulltext, SARS, 치료제, [키워드] absence Admission advanced age antiviral efficacy benefit Brazil Comorbidities Comorbidity COVID-19 COVID-19 pandemic curative demonstrated determine diagnosed with COVID-19 drug Efficacy Endotracheal intubation evaluate HCQ health problem heparin hospital Hospitalized Hydroxychloroquine ICU ICU admission immunomodulatory properties immunomodulatory property in vitro experiments in vivo independent independent predictor independent predictors lack male male predominance mechanical ventilation median age morbidity and mortality Mortality Multivariate analysis no difference outcome outcomes Patient patients hospitalized patients treated predict predictor Prognostic factor Prognostic factors Prophylactic public health reducing mortality Result RT-PCR single-center therapeutic Univariate analysis with COVID-19 [DOI] 10.1186/s12879-022-07110-1 PMC 바로가기 [Article Type] Research
HLA-C*04:01 Affects HLA Class I Heterozygosity and Predicted Affinity to SARS-CoV-2 Peptides, and in Combination With Age and Sex of Armenian Patients Contributes to COVID-19 SeverityHLA-C*04:01 SARS-CoV-2 펩티드에 대한 HLA 클래스 I 이형접합 및 예측된 친화도에 영향을 미치고 아르메니아 환자의 연령 및 성별과 함께 COVID-19 심각도에 기여Immunology Published on 2022-02-032022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% CI advanced age affinity affinity to SARS-CoV-2 age Antigen Armenian population Armenians association Asymptomatic Asymptomatic COVID-19 AUC carriers change class contribute contributed Control COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 severity COVID-19 susceptibility decrease deficiency demographic variable disease severity disease symptom distribution dose-dependent manner Effect examined Frequency Genotype Health heterozygosity HLA HLA allele HLA classical genes HLA-B HLA-B*51:01 HLA-C HLA-C*04:01 HLA-C*04:01 allele HLA-I heterozygosity homozygous Hospitalization host immunity incidence Infection Interaction leukocyte loci Male sex outcome Patient patients peptide Personalized medicine predicted Prevalence Protective provided recognize risk SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 peptides severe COVID-19 severity severity risk modelling Sex significant increase significantly subgroup the disease the SARS-CoV-2 translated Variability [DOI] 10.3389/fimmu.2022.769900 PMC 바로가기 [Article Type] Immunology
The Turkish experience of COVID-19 infection in people with NMOSD and MOGAD: A milder course?NMOSD 및 MOGAD 환자의 COVID-19 감염에 대한 터키의 경험: 더 가벼운 과정?Article Published on 2022-02-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] advanced age analyzed clinical factors comorbid conditions condition consequence coronavirus Course COVID-19 COVID-19 infection disease Disease modifying treatment disease severity disorder Factor feature glycoprotein groups Hospitalization Infection information multisystemic Myelin Myelin oligodendrocyte glycoprotein antibody-associated disorders Neuromyelitis Optica Neuromyelitis optica spectrum disorders outcome Patient patients risk SARS-CoV-2 seropositive Severe COVID-19 Infection severity significant effect statistically significant Treatment variable were recorded [DOI] 10.1016/j.msard.2021.103399 PMC 바로가기 [Article Type] Article
Outcome of SARS-CoV-2-Infected Polish Patients with Chronic Lymphocytic LeukemiaArticle Published on 2022-01-222022-10-31 Journal: Cancers [Category] COVID-19, [키워드] acute respiratory syndrome Administered advanced age Analysis Anti-CD20 antibody chronic chronic lymphocytic leukemia clinical experience CLL CLL patient Concentration coronavirus Course COVID-19 COVID-19 patient death died elevated lactate dehydrogenase Factor Hematological malignancy hemoglobin Hospitalization increased risk Infection inhibitor leukemia naïve outcome Patient performance status performed Platelet Prognosis required Retrospective study risk of death SARS-CoV-2 SARS-COV-2 infection significantly shorter simple survival the SARS-CoV-2 therapy treated Treatment tyrosine venetoclax with COVID-19 worldwide pandemic [DOI] 10.3390/cancers14030558 PMC 바로가기 [Article Type] Article
Antibody Responses after SARS-CoV-2 Vaccination in Patients with Liver Diseases간 질환 환자에서 SARS-COV-2 백신 접종 후 항체 반응Brief Report Published on 2022-01-212022-09-01 Journal: Viruses [Category] 진단, 치료기술, [키워드] Adequate advanced age age anti-SARS-CoV-2 anti-SARS-CoV-2 antibody Antibody titers Breakthrough infection cirrhosis coefficient Control controls correlated Efficacy Humoral response humoral responses IgG antibodies IgG antibody Immunosuppression Immunosuppressive treatment Liver disease liver diseases mRNA-based vaccine multivariable analysis Neutralizing activity no difference no differences Patient paucity of data post vaccination profiles reported response Safe SARS-CoV-2 SARS-CoV-2 vaccine seroconversion rates Side effect symptomatic vaccination [DOI] 10.3390/v14020207 PMC 바로가기 [Article Type] Brief Report
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques붉은 털 원숭이에서 SARS-CoV-2 감염 중 면역 역학의 연령 관련 차이Research Article Published on 2022-01-172022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] advanced age age aging Analysis animal animals Antiviral Bronchoalveolar lavage fluid Cellular immune response cellular immune responses clinical observations Clinical signs cohorts cytokine cytokine level cytokine levels difference disease eight evaluated exhibited flow cytometry immune Immune homeostasis immune response immune responses immunohistochemistry impair Increased inflammation-associated gene inflammation-associated genes Inflammatory Innate immune defense innate immune defenses inoculated lipid mediator Local macaque mediator multiplex Older outcomes pro-inflammatory response pulmonary infiltrates responses return rhesus rhesus macaque rhesus macaques risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 single-cell Single-cell transcriptomics sustained T-cell Response T-cell responses Thoracic transcriptomics various tissues Viral viral RNA quantification virus replication [DOI] 10.26508/lsa.202101314 PMC 바로가기 [Article Type] Research Article
Clinical Characteristics of COVID-19 Patients in a Regional Population With Diabetes Mellitus: The ACCREDIT Study당뇨병이있는 지역 인구에서 Covid-19 환자의 임상 적 특성 : 공인 연구Multicenter Study Published on 2022-01-132022-08-31 Journal: Frontiers in Endocrinology [Category] 바이오마커, [키워드] 30-Day mortality Admission advanced age age analyses Analysis analyzed biochemical blood glucose BMI Characteristics CKD clinical clinical and biochemical characteristics cohort study collecting data complications conducted COVID-19 CRP dataset death diabete diabetes Glucose glycaemic control greater higher risk hospital hospitalised identify insulin intensive care IQR lower risk Median BMI men Mortality Multivariate analysis multivariate logistic regression objective observational study occurred on admission Patient performed Population Predictive Primary outcome proportion random Regional remained required Research design resources Result Risk factors risk of death robust splitting type 2 diabete type 2 diabetes with COVID-19 younger patient younger patients [DOI] 10.3389/fendo.2021.777130 PMC 바로가기 [Article Type] Multicenter Study
Usefulness of the neutrophil-to-lymphocyte ratio in predicting the severity of COVID-19 patients: a retrospective cohort studyArticle Published on 2022-01-012022-11-16 Journal: São Paulo medical journal = Revista paulista de medicina [Category] SARS, 치료기술, [키워드] Accuracy addition Admission advanced age age Analysis Anemia AUC calculated Chronic diseases Clinical outcome cohort study collected Coronavirus disease-19 COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill patient critically ill patients cutoff value determine disease detection effective electronic medical records Gender hospital ICU in-hospital mortality intensive care IQR Laboratory test Leukocytosis lymphopenia median age Medical resources Neutrophil-to-lymphocyte ratio NLR Pandemics parameter Patient poor prognosis PPV Prognosis public health receiver operating characteristic retrospective cohort study risk ROC sensitivity severity of COVID-19 specificity threshold vital signs was performed was used [DOI] 10.1590/1516-3180.2021.0298.R1.27052021 PMC 바로가기