Single-cell RNA sequencing reveals immunological rewiring at the maternal-fetal interface following asymptomatic/mild SARS-CoV-2 infection단일 세포 RNA 시퀀싱은 무증상/경증 SARS-CoV-2 감염 후 모체-태아 경계면에서 면역학적 재배선을 밝힙니다.Article Published on 2022-06-142022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome adverse outcome Antigen presentation Blood CD4/CD8 coronavirus Coronavirus 2019 COVID-19 CP: Immunology CP: Microbiology decidua disease Frequency IFN immune activation immunological Infection macrophages observation offspring Placenta Pregnancy pregnant women Regulatory T cell response reveal RNA sequencing SARS-CoV-2 SARS-COV-2 infection Signaling signaling pathways T cell T cell receptor T cells TCR Type I IFN type I interferon upregulated while [DOI] 10.1016/j.celrep.2022.110938 PMC 바로가기 [Article Type] Article
An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse ModelADAM17 중화 항체는 COVID-19 마우스 모델에서 바이러스 부담을 증가시키면서 염증과 사망률을 감소시킵니다Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 ADAM17 ADAM19 adverse outcome Alter angiotensin anti-viral role antibody appear blockade blocked burden Cell cell entry receptor cellular activation cleave COVID-19 COVID-19 pathogenesis COVID-19 patients Critical ectodomain Increasing Inflammation Inflammatory inflammatory cascade K18-hACE2 less lung Lung pathology lung; metalloproteinase mice Model monoclonal antibody mouse mouse model pathway Proinflammatory cytokine promote protease Proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 viruses significantly increased significantly lower therapeutic TNF-α Transgenic mouse transmembrane viral burden virus while [DOI] 10.3389/fimmu.2022.918881 PMC 바로가기 [Article Type] Article
COVID-19 article altimg-small=kintcovid_s.svg altimg=kintcovid_o.svg>The Longitudinal Evolution of Post–COVID-19 Outcomes Among Hemodialysis Patients in TurkeyResearch article Published on 2022-06-012022-10-05 Journal: Kidney International Reports [Category] 바이오마커, [키워드] adverse outcome age baseline Characteristics Complication conducted COVID-19 COVID-19 group Follow-up HD group Hemodialysis high mortality home oxygen therapy increased risk independent parameter Infection investigated longitudinal Lower respiratory tract Mortality multicenter observational study multivariable analysis National nationwide study Odds ratio outcome Patient patients problems rehospitalization respiratory problems respiratory symptoms Result significantly higher survival thrombosis Turkey Vascular was selected [DOI] 10.1016/j.ekir.2022.03.017 [Article Type] Research article
COVID-19 in patients with cancer: first report of the ESMO international, registry-based, cohort study (ESMO-CoCARE)Research article Published on 2022-06-012022-10-05 Journal: ESMO open [Category] COVID19(2023년), SARS, 바이오마커, [키워드] active cancer active malignancy acute respiratory syndrome Advanced cancer adverse outcome African age Analysis BMI body mass index Cancer cancer stage Characteristics Clinical features cohort study collected Comorbidities Cooperative coronavirus disease Coronavirus-2 country COVID-19 COVID-19 diagnosis COVID-19 in patient COVID-19-related death cut-off death demographics diagnosed Diagnosis disease Europe European Factor female Follow-up group haematological malignancies Hospitalization include Inflammation information intensive care International investigated laboratory measurements Male sex malignancies management median Mild multivariable analysis Neutrophil-to-lymphocyte ratio NLR North Older age oncology outcome Patient patients required hospitalization Patients with cancer performance status predict Predictive presence of comorbidities Prognostic factor real-world data receiving recorded Result SARS-CoV-2 SARS-COV-2 infection score severity Sex smoking survival symptomatic disease Treatment with COVID-19 [DOI] 10.1016/j.esmoop.2022.100499 [Article Type] Research article
Body mass index and its association with COVID-19 clinical outcomes: Findings from the Philippine CORONA studyResearch article Published on 2022-06-012022-10-05 Journal: Clinical nutrition ESPEN [Category] 바이오마커, [키워드] abnormality Admission adverse outcome Analysis analyzed Asia-Pacific association being BMI body mass body mass index coronavirus disease correlated COVID-19 COVID-19 admission criteria Cutoff finding group IMV in-hospital mortality independent intensive care Invasive mechanical ventilation investigated large cohort multicenter neurologic neurological obesity outcome outcomes Patient Primary outcome Result retrospective cohort study risk SARS-CoV-2 shown underweight WHO with COVID-19 [DOI] 10.1016/j.clnesp.2022.03.013 [Article Type] Research article
Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain Research Published on 2022-05-262022-10-05 Journal: Communications Medicine [Category] 치료기술, [키워드] adverse outcome Anxiety Brain brain development brain tissue calculated change Cohort cohorts consequence Control cortical COVID-19 COVID-19 pandemic Depression depression score distress Effect enrolled estimating equation fetal Generalized growth lobe lobes Local Maternal Measures MRI occipital offspring pandemic pregnancies Pregnancy pregnant Psychological distress Result scanner significantly higher Stress Volume [DOI] 10.1038/s43856-022-00111-w [Article Type] Research
Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy Research Published on 2022-05-102022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI Admission adverse outcome affecting appear Cohort COVID-19 COVID-19 mRNA Vaccination COVID-19 vaccination COVID-19 vaccine death Effectiveness evaluated Evidence gestation higher risk intensive care Meta-analysis mRNA vaccination mRNA vaccines Neonatal outcome placental Pregnancy pregnant reduction in risk RT-PCR Safe Safety SARS-COV-2 infection second dose significantly lower Stillbirth vaccination Z-score [DOI] 10.1038/s41467-022-30052-w [Article Type] Research
Chitinase-3-like protein-1 at hospital admission predicts COVID-19 outcome: a prospective cohort study Research Published on 2022-05-092022-10-05 Journal: Scientific Reports [Category] 바이오마커, 치료법, [키워드] admitted to ICU adverse outcome age Analysis CHI3L1 Clinical outcome collected Comorbidities Control controls COVID-19 COVID-19 patient Cox regression analysis death died disease disease onset disease severity elicit evaluated healthy volunteer Hospital admission ICU inflammatory stimuli initial intensive care involved Kaplan–Meier log rank test non-ICU outcome Patient plasma predict Primary outcome Prognosis prospective cohort study Sex significantly higher survivor symptom onset systemic inflammation the median tissue damage transfer was collected [DOI] 10.1038/s41598-022-11532-x [Article Type] Research
The balancing role of distribution speed against varying efficacy levels of COVID-19 vaccines under variants변종에 따른 COVID-19 백신의 다양한 효능 수준에 대한 유통 속도의 균형 역할Article Published on 2022-05-062022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accessibility adverse outcome adverse outcomes attack rate caused COVID-19 COVID-19 pandemic COVID-19 vaccine deaths distribution Effectiveness Efficacy evaluated example Hospitalization hospitalizations immunization Infection initial Interaction key factor Mutation occurred pandemic public health raised reduce reducing regions SARS-CoV-2 speed Spread the vaccine understanding vaccination Vaccine variant variants [DOI] 10.1038/s41598-022-11060-8 PMC 바로가기 [Article Type] Article
Evaluating the role of transthoracic echocardiography in hospitalised patients with COVID-19 infectionObservational Study Published on 2022-05-012022-10-04 Journal: Open Heart [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome Admission adverse outcome analysed association cardiovascular risk case fatality ratio Cohort cohort study coronavirus COVID-19 COVID-19 pandemic demonstrated diagnostic Diagnostic imaging dysfunction Echocardiogram echocardiographic echocardiography Ejection fraction elevated eligibility criteria Evaluating exploratory feature Features hospital hospitalised hospitalised patient hypertension identify Infection inpatient admission intensive care investigated Mortality myocardial injury myocarditis n=36 non-survivor outcomes parameter Patient PCR polymerase chain positive patient preserved raised retrospective RV dysfunction SARS-CoV-2 significantly troponin levels TTE ventricular virus was performed with COVID-19 [DOI] 10.1136/openhrt-2021-001854 PMC 바로가기 [Article Type] Observational Study