A Novel SARS-CoV-2 Viral Sequence Bioinformatic Pipeline Has Found Genetic Evidence That the Viral 3′ Untranslated Region (UTR) Is Evolving and Generating Increased Viral DiversityMicrobiology Published on 2021-06-212022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3cpsdummy′UTR accumulating Analysis analyzed annotation arising assist B.1.1.7 Bioinformatic conserved dataset Diversity downstream format Frequency Genetic testing Genome genomes greater Host immune response inactivation Increased interfere K68 less novel nucleotide diversity (π) orf3a gene ORF8 ORF8 gene performed Polymorphisms processed Region regions researcher SARS-CoV-2 SARS-CoV-2 genome sequencing SARS-CoV-2 lineage SARS-CoV-2 sequencing SARS-CoV-2 variants SARS-CoV-2 viral sequence sequencing errors Spread stop codon Tajima’s D-statistic United Kingdom UTR variant Variation VCF viral evolution virulence [DOI] 10.3389/fmicb.2021.665041 PMC 바로가기 [Article Type] Microbiology
SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes44개의 Sarbecovirus 게놈을 비교하여 SARS-CoV-2 유전자 함량 및 COVID-19 돌연변이 영향Comparative Study Published on 2021-05-112022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료법, [키워드] Analysis annotation B-cell epitope Cluster Comparative genomics conservation conserved contribute COVID-19 COVID-19 pandemic D614G Dissection E484K epitope evidence of Evolution except for experimental evidence functional mutation functional mutations Genome individual lack molecular evolution Mutation mutations N501Y Nsp3 nucleocapsid nucleotide ORF ORF3c ORF8 ORFs overlapping predicted protein-coding gene provide reported residue residues SARS-CoV-2 SARS-CoV-2 biology Sequence annotation spike-protein strain Substitution the SARS-CoV-2 Transmission valuable resource [DOI] 10.1038/s41467-021-22905-7 PMC 바로가기 [Article Type] Comparative Study
Comprehensive annotations of the mutational spectra of SARS-CoV-2 spike protein: a fast and accurate pipelineSARS-CoV-2 스파이크 단백질의 돌연변이 스펙트럼에 대한 포괄적인 주석: 빠르고 정확한 파이프라인Article Published on 2021-05-012022-09-11 Journal: Transboundary and emerging diseases [Category] SARS, 변종, [키워드] Amino acid Analysis analyzed annotation attenuation Climate climatic zone code coding coding sequences Codons Complete Comprehensive condition COVID-19 D614G variant dataset Deletion deletions encoded protein evidenced FIVE Frame Frequency Geography in-frame deletion Kruskal-Wallis test mutants mutated Mutation mutations Non-synonymous mutation outlier Protein protein-coding sequence provide Region residue residues RNA virus S protein SARS-CoV-2 SARS-CoV-2 spike sequence significantly spike Spike (S) protein | COVID-19. Spread strain Strains Substitution substitutions Surveillance synonymous the SARS-CoV-2 unique Variation variations Wuhan-Hu-1 [DOI] 10.1111/tbed.13834 PMC 바로가기 [Article Type] Article
Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and Other Coronaviruses: A Genome-wide Comparative Annotation and AnalysisComparative Study Published on 2021-05-012022-10-04 Journal: Molecular and cellular biochemistry [Category] SARS, 신약개발, [키워드] alleviate Analysis analyzed annotation cause Comparative coronavirus coronavirus 2 COVID-19 death develop diagnostic difficulty in breathing disease dry cough eight facilitate Factors Fatality rate Fever Genome genome map genomes genomic geographical location Host Human identify IFR include infecting Infection involved less MERS Middle East Mild Mutation mutational rate novel Other other coronavirus outbreak pandemic peptide Phylogenetic analysis Phylogenomics polymorphism predicted rate of infection researcher respiratory SARS-CoV SARS-CoV2 sequenced severe cases severe respiratory illness similarity SNP SNPs SSR Symptom transcriptional UTR UTR. virus virus infection WHO whole genome World Health Organization Wuhan [DOI] 10.1007/s11010-020-04027-8 PMC 바로가기 [Article Type] Comparative Study
Comorbidities and Susceptibility to COVID-19: A Generalized Gene Set Data Mining ApproachArticle Published on 2021-04-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] affected affecting annotation Anti-viral treatment appear approach Cancer cardiovascular disease Comorbidities Comorbidity condition confirmed case COVID-19 COVID-19 pandemic Critical dataset death diabetes differentially expressed gene disease category downloaded Factor Gene Expression Generalized Genes Genome-wide association study GWAS identify implication include Influenza Interaction mapping medical condition Meta-analysis obesity online tool Pathogenesis pathway Pathways reduced Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severity severity of COVID-19 significant pathway Single nucleotide polymorphism SNP SNP analysis SNPs susceptibility tissue Treatment Vaccine was determined was performed was used WHO [DOI] 10.3390/jcm10081666 PMC 바로가기 [Article Type] Article
The UCSC SARS-CoV-2 Genome BrowserArticle Published on 2021-03-242022-10-04 Journal: Nature Genetics [Category] MERS, SARS, 유전자 메커니즘, [키워드] accelerate activity Analysis annotation antibodies browser checked Community contribute coronavirus genomes COVID-19 pandemic CRISPR guide Critical curated database diagnostics downloaded Epitopes Evolutionary rate genome browser GISAID IEDB immune include Interaction International investigator lab linear mapped molecular data Mutation nucleotide PDB Phylogenetic platform predicted Primers Protein provide Rapid Research researcher resource RNA genome RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 research Sequencing Support the SARS-CoV-2 Therapies UCSC Genome Browser UniProt Vaccines viral genes viral genome viral genome sequence virus genome [DOI] 10.1038/s41588-020-0700-8 PMC 바로가기 [Article Type] Article
Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural researchArticle Published on 2021-03-232022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Agricultural genetics animal annotation Community Comparative analysis complex conserved Critical dataset DNA driver eight element epigenomics functional Gene regulation genetics Genome genomes independent information non-coding variants phenotypic predicted regulatory element Research resource resources target gene tissue traits transcription factor unique Variation [DOI] 10.1038/s41467-021-22100-8 PMC 바로가기 [Article Type] Article
Integrated intra‐ and intercellular signaling knowledge for multicellular omics analysis다세포 오믹스 분석을 위한 통합된 세포내 및 세포간 신호전달 지식Article Published on 2021-03-222022-09-12 Journal: Molecular Systems Biology [Category] 진단, [키워드] added affected Analysis annotation biological processe Computational biology Cytoscape Data analysis disease downstream facilitate homology individual cell information Interaction interactions intercellular Intercellular communication intercellular signaling intracellular signaling knowledge ligand‐receptor interactions Methods & Resources multicellular Omics integration over Pathways Protein protein complex provide provided Regulation resource resources SARS‐CoV‐2 infection Signal transduction Signaling signaling network transcriptional translation ulcerative colitis [DOI] 10.15252/msb.20209923 PMC 바로가기 [Article Type] Article
Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorderTranscriptome-wide transmission disequilibrium analysis는 자폐 스펙트럼 장애에 대한 새로운 위험 유전자를 식별합니다Research Article Published on 2021-02-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affected Analysis annotation applied ASD association autism autism spectrum Brain complex connection de novo mutation developmental disease disorder ENCODE exome sequencing studies expressed Gene Expression gene mapping Genes genetic etiology Genetic variant Genetic variation Genetic variations Genome-wide association studies Genome-wide association study GWAS human population identify implicated independent information loss-of-function Mutation offspring outcomes parent parents pathway POU3F2 protein-coding gene protein-coding genes rare mutations rare variant Rare variants recent regulated Regulatory replicated risk significance level statistical framework target transcription factor transcriptome-wide Transmission variant variants [DOI] 10.1371/journal.pgen.1009309 PMC 바로가기 [Article Type] Research Article
Toward Using Twitter for Tracking COVID-19: A Natural Language Processing Pipeline and Exploratory Data SetCOVID-19 추적을 위해 Twitter를 사용하는 방법: 자연어 처리 파이프라인 및 탐색 데이터 세트Original Paper Published on 2021-01-222022-09-10 Journal: Journal of Medical Internet Research [Category] MERS, 치료기술, [키워드] annotation application programming interface applied automatically bidirectional center Classifier collected complementary Control coronavirus COVID-19 COVID-19 outbreak Data mining data set develop disease control dual English Epidemiology evaluate expression expressions filtered future work identify infodemiology language Metadata natural natural language natural language processing objective Pandemics prevention processing programming random Random sample reported resource Result social media Spread spread of COVID-19 test results the United State The United States transformer transformers United States user utility [DOI] 10.2196/25314 PMC 바로가기 [Article Type] Original Paper