Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccinationArticle Published on 2022-02-082022-10-04 Journal: NPJ Vaccines [Category] 바이오마커, [키워드] Activation adjuvants Adverse reaction Adverse reactions antibody production Antibody titers Biomarker BNT162b2 circulating conducted correlated COVID-19 COVID-19 vaccination Efficacy EVs Extracellular extracellular vesicle Fever immune responses less local pain lymphocyte microRNA miRNA mRNA-based vaccine Pain pandemic Proinflammatory cytokine prospective cohort study RNA vaccines second dose sera serum systemic adverse reaction systemic symptoms TNF-α Vaccine vaccine efficacy Vesicle [DOI] 10.1038/s41541-022-00439-3 PMC 바로가기 [Article Type] Article
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cellsSARS-CoV-2에 대한 고친화성 중화 항체는 T 여포 보조 세포 없이 만들 수 있습니다.Article Published on 2022-02-042022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta absence Alternative pathway antibody antibody production Antiviral B cell B cell response B cell responses B.1.351 Cell cell interaction cell interactions cells complement damaged driver effective epitope epitope mapping Epitopes Evidence evidence of follicular Germinal center high affinity homologous Immunoglobulin immunoglobulin class immunoglobulin class switching Infection Inflammation Influenza influenza A influenza A virus influenza A virus infection Neutralizing neutralizing antibody occur operative pathway Patient patients Protective reactive receptor reduced responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination Sequencing severe COVID-19 Support switching T cell These data variant Viral viral infection virus infection [DOI] 10.1126/sciimmunol.abl5652 PMC 바로가기 [Article Type] Article
Comparison of Anti-SARS-CoV-2 S1 Receptor-Binding Domain Antibody Immunoassays in Health Care Workers Before and After the BNT162b2 mRNA VaccineBNT162b2 mRNA 백신 전과 후 의료 종사자의 Anti-SARS-CoV-2 S1 수용체 결합 도메인 항체 면역 측정법의 비교Article Published on 2022-02-032022-09-11 Journal: American journal of clinical pathology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] 2019-nCoV anti-RBD antibody antibody concentration antibody production assays biomedical engineering blood sample Blood samples BNT162b2 BNT162b2 mRNA BNT162b2 vaccine booster dose Care collected COVID-19 DiaSorin dose Elecsy Elecsys Engineering evaluated Health Health care IgG immunoassay immunoassays Immunoglobulin Immunoglobulin G induce interquartile range LIAISON median medians New nucleocapsid protein Nucleocapsid proteins Pfizer Pfizer-BioNTech professional RBD Receptor-binding domain Roche Roche Diagnostics S-RBD SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection Siemens Healthineers Snibe Diagnostics spike glycoprotein statistically significant tested the median the receptor-binding domain the vaccine Type of antibody U/mL vaccination Vaccine were measured worker [DOI] 10.1093/ajcp/aqab107 PMC 바로가기 [Article Type] Article
Recovery from severe persistent COVID-19 without evidence of an anti-SARS-CoV-2 antibody response in a man with mantle cell lymphoma treated with rituximab리툭시맙으로 치료받은 외투 세포 림프종 환자에서 항 SARS-CoV-2 항체 반응의 증거 없이 중증 지속성 COVID-19로부터 회복Article Published on 2022-02-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence acute lung injury anti-SARS-CoV-2 antibody antibodies antibody antibody production COVID-19 develop Evidence immunocompromised state intensive care lymphoma mantle cell occur overcome oxygen Patient Prognosis prolonged viral shedding reported resolved respond rituximab SARS-CoV-2 severe COVID-19 therapy treated Treatment viral shedding [DOI] 10.1016/j.jiac.2021.11.018 PMC 바로가기 [Article Type] Article
Hemodialysis patients with coronavirus disease 2019: reduced antibody response2019년 코로나바이러스 질환 혈액투석 환자: 항체 반응 감소Article Published on 2022-02-012022-09-11 Journal: Clinical and experimental nephrology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody antibody production Antibody Response Antibody testing balance coronavirus coronavirus disease Coronavirus disease 2019 covariate COVID-19 COVID-19 patient detect disease distribution Hemodialysis higher risk hospitalized patient hospitalized patients iFlash IgG antibodies IgG antibody immune response Immunoglobulin increased risk Maintenance hemodialysis non-severe patients Pathogens Patient patients patients with COVID-19 performed produced Propensity score propensity score matching quantified reduced respiratory retrospective cohort study S1 subunit SARS-CoV-2 severe coronavirus disease severe COVID-19 severe disease Shenzhen significantly lower Spike protein symptom onset symptomatic symptomatic COVID-19 the disease the median the S1 subunit the spike protein was performed was used [DOI] 10.1007/s10157-021-02130-8 PMC 바로가기 [Article Type] Article
Formation and Expansion of Memory B Cells against Coronavirus in Acutely Infected COVID-19 IndividualsArticle Published on 2022-01-292022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Activation analyzed antibodies antibody production Antibody Response avidity B cell B cells breadth circulating antibodies conserved coronavirus Coronaviruses COVID-19 cross-reactive Endemic expansion feature Formation generate IgG IgG antibody IgG response individual Infection investigated MBC memory memory B cell Mild naïve nucleocapsid plasmablasts Population Protein Proteins reactive reactivity Receptor binding domain Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein Severe infection subject the antibody response the N protein the S protein viral spike α-coronavirus β-coronavirus β-Coronaviruses [DOI] 10.3390/pathogens11020186 PMC 바로가기 [Article Type] Article
Time-dependent evolution of IgG antibody levels after first and second dose of mRNA-based SARS-CoV-2 vaccination in haemodialysis patients: a multicentre study혈액 투석 환자에서 mRNA 기반 SARS-CoV-2 백신 1차 및 2차 접종 후 IgG 항체 수준의 시간 의존적 진화: 다기관 연구Multicenter Study Published on 2022-01-252022-09-12 Journal: Nephrology, dialysis, transplantation : official p [Category] SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Adverse Adverse reaction age albumin antibody antibody production BNT162b2 Clinical data Cohort coronavirus coronavirus disease COVID-19 demographic dialysis dose effective Efficacy event Evolution ferritin first dose Haemodialysis higher risk identify IgG antibody immune response Immunoglobulin immunologic response implementation independent predictor median Mild mRNA vaccine mRNA vaccines mRNA-based multicentre Odds ratio of BNT162b2 pandemic Patient patients physical activity Population predicted questionnaire reduced Registered retrieved risk factor Safe SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose Seroconversion Spike protein the SARS-CoV-2 threshold vaccination Vaccine vaccine doses [DOI] 10.1093/ndt/gfab293 PMC 바로가기 [Article Type] Multicenter Study
Pharmacokinetics of high-titer anti–SARS-CoV-2 human convalescent plasma in high-risk children고위험 소아에서 고역가 항-SARS-CoV-2 인간 회복기 혈장의 약동학Clinical Trial Published on 2022-01-252022-09-12 Journal: JCI Insight [Category] 임상, 진단, [키워드] age Analysis Anti-spike anti-Spike IgG antibody antibody kinetics antibody production Antibody titer Antibody titers appear characterized children convalescent plasma coronavirus COVID-19 declined develop disease Donor ELISA assays enrolled epitope Euroimmun evaluated expected exposure to funding IgG immunoglobulins Infectious disease Kinetics Kinetics of antibodies median age Mild Mild disease neutralization capacity neutralization titer neutralizing capacity NIH passive transfer performed pharmacokinetic pharmacokinetics plasma PROTECT receive recipient Research Safe SARS-CoV-2 Serious Adverse Event Serious Adverse Events severe disease Spike protein symptom onset transferred transfused transfusion Trial registration underlying condition underlying conditions unlikely virus neutralization assays weight while [DOI] 10.1172/jci.insight.151518 PMC 바로가기 [Article Type] Clinical Trial
RBD-specific antibody responses after two doses of BBIBP-CorV (Sinopharm, Beijing CNBG) vaccineResearch Published on 2022-01-242022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] administration age analyzed antibody antibody production Antibody Response Antibody titre antibody titres approved association BBIBP-CorV Beijing COVID-19 COVID-19 disease dose Effectiveness evaluate help increasing age individual individuals information Limited marker measure multivariable model outbreak Predictive Prevent Protective reduced Result SARS-CoV-2 second dose Sex Sinopharm subjects supplementary material susceptibility the vaccine vaccination Vaccine were measured [DOI] 10.1186/s12879-022-07069-z PMC 바로가기 [Article Type] Research
Delayed Antiviral Immune Responses in Severe Acute Respiratory Syndrome Coronavirus Infected Pregnant MiceMicrobiology Published on 2022-01-212022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE2 Activation acute respiratory syndrome antibody antibody production Antibody titers cause CD8 coronavirus coronavirus disease correlated Course COVID-19 Delayed elevated examined expression Fertility IgM immune response immune responses in viral Infection interfere lung marker mice Mortality non-pregnant female occur Post-infection Pregnancy pregnant Proinflammatory cytokine proinflammatory cytokines remained reported respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2-specific IgG serum Symptom T cell T cell activation the disease the SARS-CoV-2 virus Transgenic mouse Transmission Viral load viral loads were infected [DOI] 10.3389/fmicb.2021.806902 PMC 바로가기 [Article Type] Microbiology