Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2miRNA 및 mRNA 시퀀싱 데이터의 통합 분석은 ACE2 및 TMPRSS2의 잠재적인 조절 메커니즘을 보여줍니다Research Article Published on 2020-07-292022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] ACE2 Affect Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach Atla Cell COVID-19 pandemic demethylase development enzyme Enzymes expression Genes increasingly Infection isoform isomiR JARID1B KDM5B lysine mechanism miRNA mRNA multiple tissues organ Regulation Regulatory reveal searched sequencing data Serine TMPRSS2 TMPRSS2 expression Transcription transmembrane serine protease transmembrane serine protease 2 [DOI] 10.1371/journal.pone.0235987 PMC 바로가기 [Article Type] Research Article
Expansion of Single Cell Transcriptomics Data of SARS-CoV Infection in Human Bronchial Epithelial Cells to COVID-19Research Published on 2020-07-232022-10-27 Journal: Biological Procedures Online [Category] COVID-19, [키워드] Activation acute respiratory syndrome addition Analysis applied association Atla B- and T-cells bronchial bronchial epithelial cell bronchial epithelial cells cell line coronavirus coronavirus disease COVID-19 COVID-19 patients Critical Cytokine storm database dendritic cells downregulated downregulated gene expand expansion expected functional gene Gene ontology Golgi highest homolog Human Hyperactivation immune system immunological Immunological regulations infected cell Ontology overlap pathway phosphatase platform Proinflammatory cytokine proinflammatory cytokines Protein PTEN Reactome pathways Regulation Result SARS-CoV SARS-CoV infection SARS-CoV-2 secretion Severe acute respiratory syndrome shown signaling pathways similarity Single Cell Spread System biology to define Transcriptome transcriptomics Transport Vaccine Wuhan, China [DOI] 10.1186/s12575-020-00127-3 PMC 바로가기 [Article Type] Research
The network effect: studying COVID-19 pathology with the Human Cell Atlas Comments & Opinion Published on 2020-06-302022-10-05 Journal: Nature Reviews Molecular Cell Biology [Category] Coronavirus, 유전자 메커니즘, [키워드] Atla COVID-19 pathology Human [DOI] 10.1038/s41580-020-0267-3 [Article Type] Comments & Opinion
Smoking-Mediated Upregulation of the Androgen Pathway Leads to Increased SARS-CoV-2 SusceptibilityArticle Published on 2020-05-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] ACE2 ACE2 expression Affect age analyzed androgen Asymptomatic Atla clinical disease Clinical outcome clinical variables correlated correlation courses COVID-19 COVID-19 pandemic epithelial Genes host cells Hypothesis Increased infection rate lung outcome pathway pathway enrichment Patient problems protease receptor Regulatory SARS-CoV-2 SARS-CoV-2 entry seeking sequencing data Sex smoking susceptibility the SARS-CoV-2 tissue TMPRSS2 transmembrane upregulated upregulation [DOI] 10.3390/ijms21103627 PMC 바로가기 [Article Type] Article
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosaArticle Published on 2020-02-242022-10-29 Journal: International Journal of Oral Science [Category] COVID-19, SARS, [키워드] 2019-nCoV ACE2 ACE2 receptor analyzed annotation Atla Biomarkers CAP Cell Clinical practice collected database dataset demonstrated Diseases epithelial cell Evidence explained expressed expression Final high risk host cell receptor identify independent Infection mechanism mucosa oral mucosa organ profile proportion provided receptor reported RNA-Seq single-cell transcriptome susceptibility tissue tongue virus were used [DOI] 10.1038/s41368-020-0074-x PMC 바로가기 [Article Type] Article
Atlas of coronavirus replicase structureArticle Published on 2013-12-162022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Atla bioinformatics coronavirus Coverage Cryoelectron microscopy functional in viral International Microscopy NMR NMR spectroscopy nonstructural protein Pathogenesis produced Protein protein structure Proteins Replication SARS Coronavirus SARS-CoV Small angle X-ray scattering Structure structures variety X-ray crystallography X-ray scattering [DOI] 10.1016/j.virusres.2013.12.004 PMC 바로가기 [Article Type] Article