Favipiravir Versus Arbidol for Clinical Recovery Rate in Moderate and Severe Adult COVID-19 Patients: A Prospective, Multicenter, Open-Label, Randomized Controlled Clinical TrialPharmacology Published on 2021-09-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 1:1 addition Adverse adverse event antiviral therapy Arbidol assigned auxiliary caused clinical clinical recovery collected conducted contributed Controlled coronavirus disease cough COVID-19 COVID-19 patient COVID-19 patients Drug administration Effect effective Efficacy and safety enrolled Favipiravir IMPROVE initial symptom latency mechanical ventilation Mild Multicenter trial noninvasive Open-label oxygen saturation Oxygen therapy Patient patients with COVID-19 Primary outcome Prospective Pyrexia Randomized Randomized controlled trial Randomly Rate receive respiratory frequency Safety SARS-CoV-2 Secondary outcomes serum significantly therapy treat Treatment umifenovir umifenovir (arbidol) uric acid Ventilation was increased [DOI] 10.3389/fphar.2021.683296 PMC 바로가기 [Article Type] Pharmacology
A novel deep learning based method for COVID-19 detection from CT imageResearch article Published on 2021-09-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 치료기술, [키워드] Accuracy auxiliary Batch normalization block Combination COVID-19 COVID-19 detection method COVID-19 diagnosis Critical dataset deep learning Deep Learning Model Diagnosis Disease diagnosis evaluate excitation expressed function GPU help identify information limitation Metrics Mish function normalization pandemic parameter patients Prevent Public Hospital rate of infection recent Spread Squeeze virus virus infection was used WHO World Health Organization [DOI] 10.1016/j.bspc.2021.102987 [Article Type] Research article
Characterization of the Human Oropharyngeal Microbiomes in SARS‐CoV‐2 Infection and Recovery PatientsClinical Trial Published on 2021-08-222022-10-04 Journal: Advanced Science [Category] MERS, SARS, 임상, [키워드] auxiliary characterization Classifier collected confirmed case coronavirus disease correlated correlation COVID‐19 COVID‐19 decrease demonstrated diagnosed diagnosing diagnostic Efficacy eight healthy control Human IgG antibody marker microbial Microbiome microbiota MiSeq noninvasive biomarkers noninvasive diagnosis opportunistic pathogen Oropharyngeal oropharyngeal microbiome oropharyngeal swab Patient Perspective positive random reached reduced Research respiratory Respiratory tract infections SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Sequencing significant difference Spearman correlation analysis subjects validation cohorts [DOI] 10.1002/advs.202102785 PMC 바로가기 [Article Type] Clinical Trial
Quantitative CT for detecting COVID‑19 pneumonia in suspected cases의심되는 경우에서 Covid -19 폐렴을 검출하기위한 정량적 CTResearch Article Published on 2021-08-192022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] analyzed artificial intelligence assist automatically auxiliary Chain Reaction characteristic Computed tomography consolidation Convolutional neural network Corona COVID-19 COVID-19 pneumonia COVID‐19 diagnosing diagnosis of COVID-19 diagnostic value effective excluded expected GGO Ground glass opacity Hounsfield unit Hounsfield units Infection lobe lobes lung lung lesions negative RT-PCR nine parameter Patient patients with COVID-19 PCR test Pneumonia polymerase chain polymerase chain reaction positive provide public health Quantification method Quantitative Quantitative CT receiver receiver operating characteristic Result reverse transcription right lung ROC RT-PCR RT-PCR test sensitivity specificity statistical difference statistical differences statistically supplementary material Suspected cases threshold Threshold segmentation thresholds to define two groups Virus Disease VoC Volume was used were used worldwide pandemic [DOI] 10.1186/s12879-021-06556-z PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus-2 Inactivation Activity of the Polyphenol-Rich Tea Leaf Extract with Concentrated Theaflavins and Other Virucidal Catechins중증 급성 호흡기 증후군 코로나바이러스-2 농축 테아플라빈 및 기타 바이러스성 카테킨을 함유한 폴리페놀이 풍부한 찻잎 추출물의 불활성화 활성Article Published on 2021-08-082022-09-10 Journal: Molecules [Category] MERS, SARS, 치료제, [키워드] absence activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed auxiliary catechin Cell Cell culture cell culture medium cells coronavirus culture media culture medium death ENhance evaluate evaluated Extract Genome Impact in vitro incubated Incubation Infection inhibited inhibition activity leaf Measures media Other polyphenol producing provided real-time RT-PCR replaced respiratory RT-PCR S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus structural protein structural proteins suggested tea tea leaf extract the cell the cells the S protein theaflavin Treatment Ty-1 Viral viral genome Viral protein Viral proteins Viral RNA viral titer viral titers virucidal virucidal activity western blotting [DOI] 10.3390/molecules26164803 PMC 바로가기 [Article Type] Article
High-quality chest CT segmentation to assess the impact of COVID-19 diseaseCOVID-19 질병의 영향을 평가하기 위한 고품질 흉부 CT 분할Original Article Published on 2021-08-062022-09-10 Journal: International Journal of Computer Assisted Radiolo [Category] MERS, SARS, 치료기술, [키워드] 3D model Abnormalities affected airway airways Algorithm anatomical automated Automatic auxiliary Awareness Chest CT chest CT examination Chest CT image Chest CT images conducted COVID-19 COVID-19 disease COVID-19 infection COVID-19 pneumonia COVID-19 positive patient creating CT CT scans Diagnostic method effort ENhance extension false-negative faster gravity healthy Infection initial investigated knowledge lung Lungs Manifestations outlined pathological conditions pathology Patient PCR tests Pneumonia positive patients progression proprietary software quantification reduction in required respiratory Respiratory system Result RT-PCR tests Segmentation severity severity of COVID-19 Spread subject volumetric was performed [DOI] 10.1007/s11548-021-02466-2 PMC 바로가기 [Article Type] Original Article
Impact of the COVID-19 Pandemic on the Mental Health of Nurses and Auxiliary Nursing Care Technicians—A Voluntary Online SurveyArticle Published on 2021-08-052022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] ANCTs Anxiety auxiliary Care carried category Combination Coping strategy COVID-19 COVID-19 pandemic cross-sectional Depression determine Efficiency First wave HADS Health health workers healthcare healthcare worker Impact IMPROVE mental health Nurse Nursing pandemic professionals promoted Psychological questionnaire second wave Spain statistically significant difference Stressor subject survey symptoms of depression voluntary [DOI] 10.3390/ijerph18168310 PMC 바로가기 [Article Type] Article
Hydrogen peroxide as an auxiliary treatment for COVID-19 in Brazil: a randomized double-blind clinical trialRandomized Controlled Trial Published on 2021-08-032022-10-04 Journal: Epidemiology and Health [Category] MERS, 임상, [키워드] active infection acute respiratory syndrome adverse effect antibodies applied auxiliary average Brazil clinical trial control group coronavirus coronavirus disease cough COVID-19 COVID-19 patient COVID-19 symptom double-blind Dyspnea effective Effectiveness Effects evaluated experimental group family member groups had no hospital hydrogen hydrogen peroxide independent loss of taste nasal no significant difference Patient patients positive Randomized researcher SARS-CoV-2 significant difference Symptom transient adverse treated Treatment treatment for COVID-19 [DOI] 10.4178/epih.e2021051 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Effects of the COVID-19 Pandemic on Teleworking and Education in a Romanian Higher Education Institution: An Internal Stakeholders PerspectiveArticle Published on 2021-08-022022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] activities activity Analysis analyzed auxiliary component condition COVID-19 COVID-19 pandemic education Effect effort Factor Factors Faculty of Business and Administration FIVE higher education institution household activities identify internal internal stakeholders organizations Perspective Physical inactivity processed Psychological well-being Quantitative Research SPSS statistical teleworking Well-being [DOI] 10.3390/ijerph18158180 PMC 바로가기 [Article Type] Article
Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike proteinResearch article Published on 2021-08-012022-10-05 Journal: Vaccine: X [Category] 치료제, [키워드] Anti-viral anti-viral antibody antibody Antibody Response antigen-specific T cell Antiviral approach auxiliary B cell repertoire Cell characterized components convalescent COVID-19 patient convalescent patient convalescent plasma COVID-19 COVID-19 convalescent patient COVID-19 patient demonstrated effective expected full-length full-length protein humoral identify Immunoglobulin majority membrane memory B memory B cell monoclonal antibody nucleocapsid ORF performed produced Protein Proteins Pseudovirus neutralization assay RBD reveal S protein SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection Somatic hypermutation specific antibody spike the antibody the receptor-binding domain the Spike the spike protein Viral proteins [DOI] 10.1016/j.jvacx.2021.100098 [Article Type] Research article