The Role of Viral Proteins in the Regulation of Exosomes BiogenesisArticle Published on 2021-05-132023-08-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] E형 간염, [키워드] biogenesis Exosomes Extracellular vesicles regulate virus [DOI] 10.3389/fcimb.2021.671625 PMC 바로가기
Exploiting Connections for Viral ReplicationCell and Developmental Biology Published on 2021-03-182022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] acute respiratory syndrome biogenesis biosynthetic cellular membrane Contact coronavirus coronavirus disease COVID-19 dependent on double membrane vesicles (DMVs) Evidence generate Host host cell immune response implicated Like Lipid lipid metabolism lipid transport mechanism membrane Membrane contact sites (MCS) organelle pandemic Pathways positive replicate Replication RNA SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2–infected cells Support Vesicle viral replication virus viruses [DOI] 10.3389/fcell.2021.640456 PMC 바로가기 [Article Type] Cell and Developmental Biology
Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptorIpomoeassin-F는 SARS-CoV-2 스파이크 단백질과 숙주 세포막 수용체의 시험관 내 생합성을 억제합니다125 Published on 2021-02-152022-09-10 Journal: Journal of Cell Science [Category] MERS, 치료제, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents assembly biogenesis biosynthetic block causative agent Cell-free translation component COVID-19 Endoplasmic reticulum envelope enzyme ER membrane ER membrane complex highlight highlighting Host host cell host cell membrane human cell in vitro inhibit inhibitor insertion mechanisms membrane protein Membrane proteins ORF8 protein ORF8 proteins paper pathogenic pathogenicity Pathogens Person plasma membrane Protein Protein target receptor reducing respiratory Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Sec61 Sec61 translocon small molecule Spike protein structural proteins synthesised the SARS-CoV-2 therapeutic translocation Viral Viral particles viral pathogens Viral protein biogenesis viral spike viruses [DOI] 10.1242/jcs.257758 PMC 바로가기 [Article Type] 125
Mechanistic and Therapeutic Implications of Extracellular Vesicles as a Potential Link Between Covid-19 and Cardiovascular Disease ManifestationsCell and Developmental Biology Published on 2021-02-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] accompanied ACE2 Affect Angiogenesis biogenesis Cardiomyopathy cardiosphere-derived cell cardiovascular cardiovascular disease Cardiovascular function CD9 Cell cell entry cells circulating contribute coronavirus disease COVID–19 disease docking endocytic EVs Exosomes Extracellular extracellular vescicles fibrosis highlight infected cell information manifestation Manifestations mechanisms membrane MSC derived exosomes Particles pathological conditions physiological Potential promote RAS receptor released renin—angiotensin—aldosterone system responsible SARS-CoV-2 secretion secretory pathway Signaling stem cell Therapies transfer uninfected cells Vesicle virus [DOI] 10.3389/fcell.2021.640723 PMC 바로가기 [Article Type] Cell and Developmental Biology
Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19Article Published on 2021-02-032022-10-04 Journal: Scientific Reports [Category] MERS, 치료제, [키워드] acute respiratory syndrome Affect alarmin Analysis approach Biochemistry biogenesis Biotechnology carried caused Cell cellular pathway characterized complementary coronavirus Coronavirus disease 2019 Coronavirus replication correlated COVID-19 COVID-19 disease COVID-19 patient Critical cytokine Disease progression Diseases identify IL-17 Inflammation intensive care involved key factor Lipid lipid metabolism Mild moderate modulate Molecular medicine Pathogenesis pathway patients with COVID-19 profiles progression Proinflammatory cytokine SARS-CoV-2 SARS-CoV-2 infections serum severe symptom severity Spread therapeutic targets TSLP Vesicle virus virus entry virus propagation were measured [DOI] 10.1038/s41598-021-82426-7 PMC 바로가기 [Article Type] Article
Promising Extracellular Vesicle-Based Vaccines against Viruses, Including SARS-CoV-2Review Published on 2021-01-272022-10-28 Journal: Biology [Category] COVID-19, [키워드] adjuvants Antigen display Antigen presentation antigens Antiviral B cell biogenesis biological processes cell-to-cell communication Characteristics conventional vaccine COVID-19 displaying dissemination DNA Efficiency EVs Exosomes flexible heterogeneous highlighting human cell Immune cell immune responses immunogenic profile Including induce infected cell Infection Intercellular communication limit limitation lipids mRNA overcome presenting Protein Proteins reaction Reactions RNAs Safe SARS-CoV-2 secreted simple spike strong immune response T cell the SARS-CoV-2 therapeutic agents transfer uninfected cell unique Vaccine Vaccine design Vaccines Vesicle Viral antigen Viral protein Viral proteins [DOI] 10.3390/biology10020094 PMC 바로가기 [Article Type] Review
Membrane Microvesicles as Potential Vaccine CandidatesReview Published on 2021-01-242022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] addition Antigen approach Bacterial pathogens biogenesis candidate cellular immune responses criterion Delivery system demonstrated Diseases effective Efficacy healthcare humoral immune Immunity immunogenic Infection Infectious disease Infectious diseases injection mechanism microvesicle Microvesicles nucleic acid organ outbreak Pandemics polysaccharide Potential PROTECT Proteins public health SARS-CoV-2 suggested target cells the vaccine Vaccine [DOI] 10.3390/ijms22031142 PMC 바로가기 [Article Type] Review
Might proton pump or sodium‐hydrogen exchanger inhibitors be of value to ameliorate SARs‐CoV‐2 pathophysiology?Review Article Published on 2020-12-252022-10-28 Journal: Physiological Reports [Category] COVID-19, [키워드] administration animal model approach benefit biogenesis bronchitis candidate cathepsin Cell cell entry cleavage complex compounds contributed CoV COVID‐19 COVID‐19 Cytokine release syndrome disease pathogenesis Disease progression disrupt disrupting drug Efficacy endocytic endosomal complexes required for transport endosomal pH entry pathway envelope exacerbate Exosome Exosomes extracellular vesicle Extracellular vesicles glycosylation Golgi Infection inhibit inhibiting inhibitor involved mechanism membrane mice Microvesicles multivesicular body occur Pathogenesis plasma membrane PPI promote Pulmonary edema pulmonary epithelial cell reported serine protease TMPRSS2 Spike protein suggested therapeutic Transport Vesicle viral endocytosis viroporin viruses [DOI] 10.14814/phy2.14649 PMC 바로가기 [Article Type] Review Article
Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies통합 이미징은 SARS-CoV-2에 의해 유도된 세포 내 형태의 재구성을 보여줍니다Article Published on 2020-12-092022-09-12 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, [키워드] alteration Analysis biogenesis Cell cell death Cluster coronavirus cytokine response Cytopathic effect cytoskeleton dataset determine electron tomography elements Endoplasmic reticulum epithelial cells FIB-SEM Golgi Golgi apparatus human lung imaging Infection intermediate filaments live cell imaging membrane membrane remodeling Microscopy mitochondrial Morphological organelle peroxisome peroxisomes recruitment Repository reveal SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected cell subcellular suppresse thought Vesicle viral replication viral replication organelles. [DOI] 10.1016/j.chom.2020.11.003 PMC 바로가기 [Article Type] Article
The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate ImmunityReview Published on 2020-10-012022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] amoeba anti-apoptotic association bind binding biogenesis Cancer cells chaperone Contact cytosolic docking E3 ubiquitin ligase Endoplasmic reticulum fungi Genome implicated Innate Innate immunity involved IP3R3 kDa Lam6 Ltc1 Macrophage mammalian cells MAVS membrane contact sites Mitochondria mitochondrial mitochondrial antiviral-signaling protein mitochondrial carrier family mitochondrial protein import motifs outer membrane Parkinson’s disease Pathogens PINK1 promote Protein receptor recruitment resolved SARS-CoV-2 Site SLC25 TOM70 TPR Traffic transfer type I interferons viral infections yeast [DOI] 10.3390/ijms21197262 PMC 바로가기 [Article Type] Review