Compartmentalized Replication of SARS-Cov-2 in Upper vs. Lower Respiratory Tract Assessed by Whole Genome Quasispecies AnalysisArticle Published on 2020-08-262022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Analysis analyzed approach Bioinformatic clade Clustering collected coronavirus COVID-19 COVID-19 patients diagnosed Evolution Frequency genetic heterogeneity Genome heterogeneous identify intensive care unit Intra-host variability Ion Italy Lower Lower respiratory tract LRT NGS no significant difference nucleotide Patient patients Quasispecies quasispecy respiratory SARS-CoV-2 Sequencing Strains supported Thermofisher tract upper URT Variability variant virus replication was performed whole-genome [DOI] 10.3390/microorganisms8091302 PMC 바로가기 [Article Type] Article
Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2Article Published on 2020-08-022022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] ACE-2 affecting AhR Air pollution Analysis angiotensin-converting enzyme 2 Aryl hydrocarbon receptor association Bioinformatic bioinformatic analysis cell receptor cellular response Concentration Consensus contributing to correlation Correlation analysis COVID-19 DNA sequence environmental factor epidemiological data evaluate fatality Fatality rate favor geographical areas Health human airway Hypothesis identify incidence inter-individual Involvement Italian mechanism mortality rate motif nine outcome over-expression pandemic PM2.5 relation risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection severity Spread Support the SARS-CoV-2 transcription factor Variability was performed xenobiotic response element [DOI] 10.3390/ijerph17155573 PMC 바로가기 [Article Type] Article
Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer PatientsResearch Paper Published on 2020-07-062022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome addition Bioinformatic Cancer cancer patient caused cell line Colon coronavirus coronavirus disease correlated correlation COVID-19 digestive enrichment analysis estimation expressed fetal GSEA healthy Immune cell infiltration immune infiltration Infection investigated male maternal-fetal transmission pathway performed Profiling reproductive SARS-CoV-2 SARS-COV-2 infection severity signaling pathways significantly suggested susceptibility tissue tissues Tumor Urinary tract [DOI] 10.7150/ijbs.48639 PMC 바로가기 [Article Type] Research Paper
In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their LifecyclesMicrobiology Published on 2020-07-032022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3′UTR acid binding Bioinformatic coronavirus determine evaluate Evidence G-quadruplex Genome genomic RNA genomic sequence Human human protein Including indicate inverted repeats loci mechanism MERS-CoV molecular motif mRNA Nidovirale notable nucleic acid nucleotides Regulation Regulatory RNA role SARS-CoV SARS-CoV-2 SARS-CoV-2 RNA sequenced Structure structures [DOI] 10.3389/fmicb.2020.01583 PMC 바로가기 [Article Type] Microbiology
Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2Article Published on 2020-05-062022-10-04 Journal: Journal of Human Genetics [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] addition allele frequency B-cell response Bioinformatic calculated CD4 CD8 Coverage COVID-19 pandemic Deleterious develop epitope high affinity High-throughput screening HLA HLA class I HLA molecules homology host immune responses immune immune system Immunogenetics induce information Japanese membrane nonstructural protein Novel coronavirus Nucleocapsid proteins other coronaviruses peptide epitope populations predicted Prevent Region SARS-CoV SARS-CoV-2 sequence significantly T cell epitope T-cell T-cell responses the SARS-CoV-2 Vaccine virus [DOI] 10.1038/s10038-020-0771-5 PMC 바로가기 [Article Type] Article
Bioinformatic analysis of differentially expressed genes involved in the hepatitis B virus-associated acute liver failureArticle Published on 2018-04-012023-06-15 Journal: Acta gastro-enterologica Belgica [Category] B형 간염, [키워드] Bioinformatic Differentially expressed genes HBV-associated acute liver failure. protein-protein interactions