blockade – Page 4 – Communicable Diseases Research

Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection

가용성 면역 체크포인트는 COVID-19 및 HIV 감염이 있는 과음 알코올 사용자의 조절이 잘 안 됩니다.

Review

Published on 2022-02-232022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커,

A Feasible Alternative Strategy Targeting Furin Disrupts SARS-CoV-2 Infection Cycle

푸린을 표적으로 하는 실행 가능한 대안 전략은 SARS-CoV-2 감염 주기를 방해합니다

Research Article

Published on 2022-02-092022-09-10
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 Activation addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody Response applicability approach binding blockade Cell cellular entry chain cleavage competing coronavirus COVID-19 Critical cycle described disease pathology DNA domain effective Efficacy epitope flexible linker furin Health Hospitalization Host host cell host cells host protease human lung cell human lung cells IgG1 Immunological memory in viral independent Infection infection cycle infections interfere lung cells membrane fusion Mortality occur overcome peptide plug processing producing protease Proteases proteolytic activation Proteolytic processing public health threat remained remains uncertain residue RNA SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viral particles scenario secretory pathway solution spike glycoprotein Spike protein Strategy subsequent targeted therapy targeting the spike protein Transmission Vaccine Viral viral entry Viral transmission virus virus-producing cell virus-producing cells viruses
[DOI] 10.1128/spectrum.02364-21 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19

SARS-CoV-2-특이 면역 반응과 COVID-19의 병인

Review

Published on 2022-02-022022-09-10
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute viral infection adaptive Adaptive immunity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Autoimmune Autoimmunity blockade causative agent cell receptors cells cellular stress Characteristics complications of COVID-19 coronavirus coronavirus disease COVID-19 Critical Cytokines Engagement expressing Factor focus Immunity immunosuppressive include induce infect infected cell infected cells Infection Inflammation initial initial stages Innate immunity interferons Invasion invasion stage involved main receptor majority mechanism molecular mechanism molecular mechanisms overcome pathogenic pathogenicity pathway Post-COVID-19 syndrome Protein receptor receptors Recognition redundancy research finding research findings respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein Stage superantigens systemic inflammation target cell the spike protein tissue variant variants Viral virulence virus
[DOI] 10.3390/ijms23031716 PMC 바로가기 [Article Type] Review

Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures

Research Article

Published on 2022-02-022022-10-30
Journal: Life Science Alliance [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] acute respiratory syndrome administration air–liquid interface airway angiotensin-converting enzyme-2 apical surface binding Bioavailability blockade blocked Camostat mesylate Cell circulation cleavage clinical trial compounds coronavirus COVID-19 Culture cultures demonstrated develop effective enzalutamide epithelial cell evaluated experiment had no human airway Infection Local metabolised Prevent primary human airway Prophylaxis receptor restrict Safe SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection serine protease serine protease inhibitor Spike protein targeting therapeutic therapeutic strategy TMPRSS2 TMPRSS2 inhibitor topical transmembrane serine protease Treatment Viral transmission
[DOI] 10.26508/lsa.202101116 PMC 바로가기 [Article Type] Research Article

Perceptions and experiences toward extended-release buprenorphine among persons leaving jail with opioid use disorders before and during COVID-19: an in-depth qualitative study

Research

Published on 2022-01-292022-10-28
Journal: Addiction Science & Clinical Practice [Category] Coronavirus, SARS,

Sequential infections with rhinovirus and influenza modulate the replicative capacity of SARS-CoV-2 in the upper respiratory tract

Coronaviruses

Published on 2022-01-272022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS,

[키워드] air–liquid interface airway epithelial cell Alpha variant blockade circulating circulation coronavirus 2 correlated COVID-19 had no IAV IBV immune response Infection Influenza Influenza virus inhibition Interaction interferon interferons investigated modulate modulated neutralizing antibody other respiratory virus pandemic patients prevalent prevented question Replication replicative reported respiratory respiratory virus respiratory viruses restored rhinovirus SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 replication suggested These data triggered type I upper respiratory tract variants of concern viral co-infections virus virus entry was impaired
[DOI] 10.1080/22221751.2021.2021806 PMC 바로가기 [Article Type] Coronaviruses

Interleukin-1 Inhibitors and Vaccination Including COVID-19 in Inflammatory Rheumatic Diseases: A Nonsystematic Review

염증성 류마티스 질환에서 코로나19를 포함한 인터루킨-1 억제제 및 백신 접종: 비체계적 검토

Review

Published on 2022-01-272022-09-11
Journal: Frontiers in Immunology [Category] 변종, 진단,

[키워드] accumulating addressed anti-cytokine anti-cytokine therapy autoimmune/autoinflammatory rheumatic diseases baseline blockade blockers blocking agent blocking agents canakinumab coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 disease COVID-19 in patient COVID-19 vaccination develop disease Disease activity drug level drug levels Efficacy and safety half-live hand healthy help IL-1 Immunosuppression Including interleukin interleukin-1 interleukin-1 inhibitors medical emergency moderate novel vaccines Patient Prognosis raise returned review rheumatic disease Rheumatic diseases rilonacept rising risk SARS-CoV-2 selected Seven severe COVID-19 disease Spread the disease the timing vaccination Vaccine vaccine response variant
[DOI] 10.3389/fimmu.2021.734279 PMC 바로가기 [Article Type] Review

Specific Interleukin-1 Inhibitors, Specific Interleukin-6 Inhibitors, and GM-CSF Blockades for COVID-19 (at the Edge of Sepsis): A Systematic Review

Pharmacology

Published on 2022-01-212022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] Affect article articles blockade Characteristics clinical CNKI Cochrane Library conducted controlled trials coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient Critically ill Cytokine storm Diagnostic Criteria edge Efficacy and safety evaluated Evidence exclusion criteria Final GM-CSF GM-CSF blockades Health high mortality identify IL-6 inhibitors Inclusion Inflammatory response inhibitors interleukin (IL)-1 interleukin-1 Meta-analysis Mortality multiple organ dysfunction Odds ratio Other outcomes pandemic Patient patients treated patients with COVID-19 people with COVID-19 protocol reduce Registration Regulation released resource review risk SAE SAEs sarilumab SARS-CoV-2 Secondary infection secondary infections Sepsis Serious Adverse Event significantly Specific specific interleukin-1 inhibitors specific interleukin-6 inhibitors statistical significance syndrome systematic review Tocilizumab Treatment was performed
[DOI] 10.3389/fphar.2021.804250 PMC 바로가기 [Article Type] Pharmacology

Significantly Increased Public Interest in Major Depressive Disorder During the COVID-19 Pandemic: Insights From a Google Trends Analysis

Psychiatry

Published on 2022-01-142022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] accumulated acute respiratory syndrome affected affecting Analysis blockade Brazil changes in confirmed case coronavirus coronavirus disease correlation country COVID-19 COVID-19 case COVID-19 pandemic cumulative cumulative mortality depressive determinant Diagnosis disorder Epidemic evaluated Factor Google Google Trends increase in Increased India insight interest Internet Intervention major depressive disorder major depressive disorder (mdd) majority mental health mental health conditions mental health problems mental illness pandemic Patient poor mental health potential risk Prevalence psychology health Public reached reduction reference standard Research Result SARS-CoV-2 School significantly social interaction suffered the United State The United States Transport trend virus virus transmission
[DOI] 10.7759/cureus.21228 PMC 바로가기 [Article Type] Psychiatry

An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)

Article

Published on 2022-01-112022-10-04
Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 임상,

[키워드] Abstract administration Anti-inflammatory approach ARDS blockade challenge chemokine Clinical data clinical trial combination therapy Concentration coronavirus disease-2019 COVID-19 Cytokine storm Cytokines dosage downstream drugs dysregulated immune response Efficacy explained Future Health hepatic injury highest Hyperinflammatory IL-6 IL-6 inhibitor IL-6 pathway IL-6 signaling IMPROVE interleukin-6 Jak-STAT Janus-kinase inhibitor lung damage membrane monotherapy non-specific Pathways pleiotropic pro-inflammatory progression pulmonary damage recent receptor reduce risk sarilumab severe coronavirus disease severe COVID-19 Side effect Signaling therapeutic approaches Tocilizumab Treatment
[DOI] 10.1016/j.intimp.2022.108536 PMC 바로가기 [Article Type] Article