Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility결합된 림프구/단핵구 수, D-이량체 및 철 상태는 장기 요양 시설에서 COVID-19 경과 및 결과를 예측합니다Research Published on 2021-02-172022-09-10 Journal: Journal of Translational Medicine [Category] MERS, 바이오마커, [키워드] Admission Analysis Blood cells Care Clinical course Clinical outcome Combination Combined Concentration Course COVID-19 D-dimer dead patient decrease evaluated ferritin form generate Granulocytes groups hemoglobin Hospital stay identify IFR interleukin interleukin-6 iron Laboratory laboratory parameter Laboratory parameters Long-term care long-term care facilities lymphocyte Lymphocytes marker monocyte Multiorgan multiorgan disease outbreak outcome Platelets predict predictor Principal component principal component analysis progression Result severe pneumonia significantly Spread statistical statistical analysis subject survival was performed were used White blood cells [DOI] 10.1186/s12967-021-02744-2 PMC 바로가기 [Article Type] Research
Furin Expression in Patients With Psoriasis—A Patient Cohort Endangered to SARS-COV2?Medicine Published on 2021-02-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ACE2 expression analyzed Angiotensin converting enzyme-2 Arthritis baseline biologic blood cell Blood cells blood sample clinical clinical trial Control controls Course COVID-19 decreased expression Endangered enzyme evaluate Express expression expression level expression levels Follow-up furin host cell in viral induce Infection mRNA expression not differ overexpressed Patient patients patients treated psoriasis psoriatic arthritis raised reduce registry retrieved risk SARS-CoV-2 Secukinumab severe COVID-19 significantly significantly increased therapeutic intervention translational Treatment treatment initiation untreated patients ustekinumab [DOI] 10.3389/fmed.2021.624462 PMC 바로가기 [Article Type] Medicine
Differences of blood cells, lymphocyte subsets and cytokines in COVID-19 patients with different clinical stages: a network meta-analysis임상 단계가 다른 COVID-19 환자의 혈액 세포, 림프구 하위 집합 및 사이토카인의 차이점: 네트워크 메타 분석Meta-Analysis Published on 2021-02-082022-08-31 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, meta-analysis, [키워드] 95% CI Analysis Blood blood cell Blood cells CD19 CD3 CD4 CD8 Cell Clinical stages conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical critical patients cytokine Cytokines database determine difference elevated Guidance IL-10 IL-1β IL-6 immune Immune suppression Inflammatory inflammatory parameter Injury lymphocyte Lymphocyte subset Lymphocyte subsets mean difference Meta-analysis mild patients network Network meta-analysis neutrophil Patient patients performed Platelet progression Result searched severe and critical patients severity significantly significantly lower Spread Stata supplementary material susceptible cell the disease the mean Treatment WBC were used white White blood cell worsening [DOI] 10.1186/s12879-021-05847-9 PMC 바로가기 [Article Type] Meta-Analysis
Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco심각한 형태의 COVID-19와 관련된 혈액학적 및 생화학적 이상: 모로코의 후향적 단일 센터 연구Observational Study Published on 2021-02-042022-09-10 Journal: PLoS ONE [Category] MERS, 임상, 치료기술, [키워드] Abnormalities abnormality Admission advanced age affected African age Alanine alanine aminotransferase Analysis analyzed aspartate Aspartate aminotransferase biochemical biological parameter biological parameters Blood cells C-reactive protein Characteristics clinical clinician Cohort Comorbidities conducted coronavirus coronavirus disease COVID-19 creatinine Critical disease CRP D-dimers deaths detect died disease Disease progression early stage environmental factor Epigenetic Evolution Factor ferritin form Genetic Genetic studies group Health Health crisis Health Sciences Hospitalization Hospitalized identify immunological individual Infection Lactate lactate dehydrogenase LDH literature review Lymphocytes male Male sex median age Mild mild to moderate mild to moderate disease moderate moderate disease MONITOR Morocco Neutrophils non-severe patients North pandemic parameter Patient patients older Predictive presence of comorbidities procalcitonin progression radiological retrospective Retrospective study risk factor Risk factors severe and non-severe patients severe disease severity single-center single-center study survived the median Univariate analysis university was performed WBC White blood cell White blood cells [DOI] 10.1371/journal.pone.0246295 PMC 바로가기 [Article Type] Observational Study
Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19호중구 세포외 트랩의 순환 마커는 COVID-19 환자에서 예후 가치가 있습니다Article Published on 2021-02-012022-09-11 Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] MERS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome association Asymptomatic Blood cells C-reactive protein cell-free DNA characterized circulating Clinical outcome Coagulation convalescent plasma coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease COVID-19 disease severity Cytokines declined Disease progression disease severity elevated endothelial damage enrolled evaluate Evidence Extracellular extracellular traps fibrinolysis healthy controls healthy individual healthy individuals histone Hospital admission hyperinflammation immunothrombosis in healthy individual in vivo Infection Inflammation Inflammatory cytokines marker moderate moderate to severe Mortality NET NETs neutrophil Neutrophil elastase Neutrophil extracellular trap Neutrophils pathogenic mechanism pathogenic mechanisms patients with COVID-19 plasma plasma sample plasma samples Post-infection progression respiratory respiratory distress Respiratory distress syndrome Respiratory Support SARS-CoV2 severe disease syndrome target targets therapeutic intervention thrombosis thrombotic thrombotic microangiopathy TRAP value were assessed White blood cells with COVID-19 [DOI] 10.1161/ATVBAHA.120.315267 PMC 바로가기 [Article Type] Article
High Levels of Circulating IL-8 and Soluble IL-2R Are Associated With Prolonged Illness in Patients With Severe COVID-19높은 수준의 순환 IL-8 및 가용성 IL-2R은 중증 COVID-19 환자의 질병 장기화와 관련이 있습니다Immunology Published on 2021-01-292022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] association Biomarker Blood cells circulating circulating cytokine circulating cytokines Coronavirus disease 2019 COVID-19 Critical cytokine cytokine receptor Cytokines disease severity duration of illness Evolution Host IL-6 IL-8 illness immune response immunological parameters immunological phenotype interleukin 6 interleukin 8 involved Level lymphocyte Lymphocytes neutrophil Neutrophil-to-lymphocyte ratio neutrophil-to-lymphocytes ratio Neutrophils objective parameter Patient progression Prolonged recruited Result SARS-COV-2 infection screened Serum level serum levels severe acute respiratory syndrome coronavirus−2 severe COVID-19 single-center study soluble interleukin 2 receptor survival T cell T cells White blood cells [DOI] 10.3389/fimmu.2021.626235 PMC 바로가기 [Article Type] Immunology
The Impact of Peripheral Eosinophil Counts and Eosinophil to Lymphocyte Ratio (ELR) in the Clinical Course of COVID-19 Patients: A Retrospective StudyCOVID-19 환자의 임상 과정에서 말초 호산구 수 및 호산구 대 림프구 비율(ELR)의 영향: 후향적 연구Article Published on 2021-01-012022-09-11 Journal: In vivo (Athens, Greece) [Category] MERS, 바이오마커, [키워드] allergens Biomarker blood cell Blood cells both groups clinical correlated count COVID-19 COVID-19 patients critical cases decrease died duration of hospitalization eosinophil eosinophil counts eosinophils evaluate Impact in both groups inflammatory conditions less Lower lymphocyte mean value moderate moderate to severe outcome parasite parasites Patient patients hospitalized peripheral predict prediction Ratio ratio. responsible Severe case severe disease statistically significant survived with COVID-19 [DOI] 10.21873/invivo.12303 PMC 바로가기 [Article Type] Article
Associations between hematological parameters and disease severity in patients with SARS-CoV-2 infectionSARS-CoV-2 감염 환자의 혈액학적 매개변수와 질병 중증도 간의 연관성Article Published on 2021-01-012022-08-31 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Analysis analyzed association Biomarker Biomarkers Blood cells calculated caused characteristic characterized complement coronavirus coronavirus disease diagnostic disease disease severity distribution Health crisis hematological parameter hematological parameters hematological parameters. high risk highest identify independent Infection Inflammatory responses lymphocyte Lymphocyte count marker mean platelet volume measure Mild disease mild illness moderate monocyte Multivariate analysis neutrophil neutrophil counts Neutrophil-to-lymphocyte ratio NLR Novel coronavirus novel coronavirus disease Older age parameter parameters Patient patients with SARS-CoV-2 Platelet Platelet count Predictive predictive values progression public health crisis receiver receiver operating characteristic Red cell regression analysis respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Spread subpopulations Univariate analysis Volume WBC WBCs were used White blood cell White blood cells with mild disease [DOI] 10.1002/jcla.23604 PMC 바로가기 [Article Type] Article
Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis중증 코로나19 환자의 인터루킨-6: 후향적 분석Clinical Trial Published on 2020-12-312022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 임상, [키워드] Admission admitted patients AUROC Blood Blood cells blood concentration C-reactive protein China clinician collected Concentration conducted coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients cytokine Cytokine storm D-dimers demographic diagnosis of COVID-19 disease evaluate ferritin help highest ICU IL-6 IL-6 level intensive care unit interleukin-6 Interleukine-6 laboratory data Lactate lactate dehydrogenase LDH lymphocyte Lymphocytes Mortality non-survivor outcome parameter pathophysiology Patient patients patients with COVID-19 poor prognosis Predictive Predictive value repeated Result Retrospective analysis Retrospective study risk severity significant difference significantly higher Spread survivor White blood cell White blood cells [DOI] 10.1371/journal.pone.0244628 PMC 바로가기 [Article Type] Clinical Trial
Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and InfectionCell and Developmental Biology Published on 2020-12-182022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Activation activity administration alarm arteriogenesis Bacteria Blood cells bypasses cardiovascular disease circulating cofactor condition Contact COVID-19 DAMP DAMPs danger-associated molecular patterns defense process demonstrated dissemination docking edema effective endothelial endothelial cells Endothelium ENhance Extracellular extracellular nucleic acids growth help histone host cell immune defense implicated in vitro in vivo include Inflammation Inflammatory inflammatory macrophages inflammatory vascular diseases influence initiate innate immune response Interaction intracellular material Invasion investigated Ischemia leukocyte limit microbial microbial infection microRNA molecular Non-coding RNAs non-toxic nucleic acid pro-thrombotic promote provide provoke Reactions recruitment regimen RNA RNase1 Safe signal subsequent therapeutic thrombosis tissue damage Vascular Vascular injury VEGF vessel vessel wall viral infection viral particle virus virus infection while wound healing [DOI] 10.3389/fcell.2020.619221 PMC 바로가기 [Article Type] Cell and Developmental Biology