Early and Mid-Term Implications of the COVID-19 Pandemic on the Physical, Behavioral and Mental Health of Healthcare Professionals: The CoPE-HCP Study ProtocolPsychology Published on 2021-02-022022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] absence addition alcohol Anxiety anxiety symptom approved association baseline Burnout Cambridge change in symptom changes changes in Cohort cohort study Confirmed COVID-19 infection controls COVID-19 COVID-19 pandemic cross-sectional survey Depression detect East equipment Ethics ethics committee evaluate Evidence Factor group hcp Healthcare professional Healthcare system initiated London mental health objective pandemic participant Participants physical Physical symptom Prevalence questionnaire reported sleep disorders Support Trial Registration Number two group two-sided unique United Kingdom wellbeing [DOI] 10.3389/fpsyg.2021.616280 PMC 바로가기 [Article Type] Psychology
Aktueller Stand der Impfung gegen SARS-CoV-2Hot Topics Published on 2021-02-022022-10-28 Journal: Zeitschrift Fur Rheumatologie [Category] COVID-19, MERS, SARS, [키워드] BNT162b2 Cambridge COVID-19 EMA Impfung Mainz Moderna mRNA vaccination mRNA Vakzine New York City Pfizer SARS-CoV-2 SARS-CoV‑2 Stand STIKO Empfehlung STIKO recommandation union USA vaccination [DOI] 10.1007/s00393-021-00966-9 PMC 바로가기 [Article Type] Hot Topics
Pregnant women’s well-being and worry during the COVID-19 pandemic: a cross-sectional studyResearch Article Published on 2021-01-152022-10-28 Journal: BMC Pregnancy and Childbirth [Category] COVID-19, [키워드] Affect Analysis Anxiety Cambridge Care caused collected conducted COVID-19 COVID-19 outbreak COVID-19 pandemic criteria cross-sectional disorder employment Factor fear First wave Health healthy identify index investigated multivariate logistic regression nulliparity participated Persian version predictor Pregnancy pregnant women Providing Psychological questionnaire Result sampling scale supplementary material Support total score was performed Well-being WHO-5 Well-being Index with COVID-19 women World Health Organization’ Worry [DOI] 10.1186/s12884-021-03548-4 PMC 바로가기 [Article Type] Research Article
The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Moderna COVID-19 Vaccine – United States, December 2020Moderna COVID-19 백신 사용에 대한 예방접종 관행 자문 위원회의 임시 권고 - 미국, 2020년 12월Article Published on 2021-01-012022-09-11 Journal: Morbidity and Mortality Weekly Report [Category] 신약개발, 임상, [키워드] Administered approach assessment authorization Cambridge cause Committee conjunction coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines development dose drug Emergency Emergency use authorization EUA FDA food Food and Drug Administration framework information initial Interim intramuscularly Massachusetts Moderna mRNA mRNA-1273 nucleoside nucleoside-modified mRNA Practice prefusion prevention of COVID-19 recommendation SARS-CoV-2 spike glycoprotein the United State the vaccine United States Vaccine virus [DOI] 10.15585/mmwr.mm695152e1 PMC 바로가기 [Article Type] Article
The COVID-19 pandemic masks the way people perceive facesArticle Published on 2020-12-212022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, SARS, [키워드] activity alteration Cambridge COVID-19 pandemic decrease Effect effort evaluated Evidence expected experiment face Face mask hallmark Human behaviour humans Inclusion interactions inversion Mask Masked face Masks Perception reduced significant effect Similar change suggested Test tested [DOI] 10.1038/s41598-020-78986-9 PMC 바로가기 [Article Type] Article
Computer-aided drug design against spike glycoprotein of SARS-CoV-2 to aid COVID-19 treatmentResearch article Published on 2020-10-152022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] 3D structure ACE2 aligned angiotensin Anti-viral drugs approach AutoDock bioinformatics Cambridge Cell cell entry Compound computational analysis computer-aided drug design conducted conserved COVID-19 COVID-19 infection criteria database docking drug Drug binding drug design drugs eight FIVE glycoprotein GRP78 host receptor immunology in silico in silico analysis Infectious disease interact interacting residue Interaction involved Lead compounds motif NCBI predicted Prevent RBD RBM RBM region receptor Receptor binding domain residue Result retrieved Safe SARS-CoV-2 screened sequence spike glycoprotein the Spike Toxicity Treatment viral entry Viral protein Virology Virtual screening viruses was performed was used [DOI] 10.1016/j.heliyon.2020.e05278 [Article Type] Research article
Performance Evaluation of the SAMBA II SARS-CoV-2 Test for Point-of-Care Detection of SARS-CoV-2SARS-CoV-2의 현장 진단을 위한 SAMBA II SARS-CoV-2 테스트의 성능 평가Virology Published on 2020-10-132022-09-10 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification Analysis analytical sensitivity Cambridge Characteristics clinical coronavirus COVID-19 detection determined by Diagnosis effective evaluated Frame Genome implementation in silico infection control majority management Measures Microbiology nose/throat swab nucleic acid nucleic acid amplification nucleocapsid protein Open reading frame open reading frame 1ab ORF1ab Patient Patient management PCR assay performance POC point of care point-of-care tests positive primer Primers probe probes provided Public Public Health England RdRP RdRp gene real-time PCR assay Region respiratory respiratory sample Respiratory samples RNA SAMBA SAMBA II SAMBA II SARS-CoV-2 SAMBA II SARS-CoV-2 test SARS-CoV-2 SARS-CoV-2 test severe acute respiratory syndrome Coronavirus simple specificity Swab Test turnaround time turnaround times [DOI] 10.1128/JCM.01262-20 PMC 바로가기 [Article Type] Virology
Approaches to screening for hyperglycaemia in pregnant women during and after the COVID‐19 pandemicCOVID-19 대유행 기간 동안과 이후에 임산부의 고혈당 검사에 대한 접근Research: Care Delivery Published on 2020-09-212022-09-12 Journal: Diabetic Medicine [Category] SARS, 진단, [키워드] 95% CI Admission age Caesarean section Cambridge characteristic clinical COVID‐19 criteria diabete Diagnosis diagnostic evaluate gestation gestational diabete Glucose glucose tolerance group identify intensive care Laboratory test Logistic regression Neonatal outcome outcomes pandemic plasma predict pregnancies Pregnancy pregnant women prognostic prospective observational study random Receiver‐operating characteristic Result risk risk factor risk stratification sensitivity significantly specificity were used WHO criteria women [DOI] 10.1111/dme.14380 PMC 바로가기 [Article Type] Research: Care Delivery
muLTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19-Experimental drugs and mechanisms (TACTIC-E): A structured summary of a study protocol for a randomized controlled trial코비드-19-실험 약물 및 기전(TACTIC-E)으로 입원한 ICu 전 환자에 대한 다중 암 치료 연구: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-07-312022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] able to swallow adaptive Adaptive trial added Admission age Ambrisentan Analysis approved Arm ARMS balloon pump balloon pump) baseline benefit Biomarker blinded Blinding calculated Cambridge Cambridge University Hospitals NHS Foundation Trust can not cardiac cardiovascular complications cells clearance clinical endpoint Clinical endpoints clinical picture clinically Combination comparator comparison Complete Composite Course COVID-19 COVID-19 infection creatinine creatinine clearance CRP Dapagliflozin Data analysis Day death defined demonstrated determine diabetes Diagnosis discretion disease dissemination drug drugs ECMO EDP1815 Efficacy element enrolled envelope EU Clinical Trial EU Clinical Trials EudraCT Evidence evidence of exclusion criteria Experimental drugs failure feature fixed foundation Gault Gender group hypertension immunomodulation immunomodulatory incidence include Inclusion independent independent data monitoring committee Inotropes Intervention Invasive mechanical ventilation investigator Laboratory late stage male mechanism membrane neutrophil Neutrophils NHS number objective Occurrence on admission once daily Open-label open-label trial opinion option Organ failure organ support Other outcome Oxygenation pandemic Parallel Arm participant Patient patients with COVID-19 performed phase platform Platform trial positive positive COVID-19 predicted Primary outcome principal investigator progression protocol Radiographic radiological randomisation randomised Randomized controlled trial recruited reduce Registered related disease renal renal failure risk Sample size severity Standard of care status stratified Study protocol subject Support tablets the patient therapy Treatment treatment arm Trial Trial registration triggered Trust university website [DOI] 10.1186/s13063-020-04618-2 PMC 바로가기 [Article Type] Letter
Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients – mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 – Repurposed Drugs (TACTIC-R): A structured summary of a study protocol for a randomised controlled trialICu 전 환자의 Covid-19에 대한 용도 변경 면역조절 약물 - Covid-19로 입원한 ICu 전 환자에 대한 다중 암 치료 연구 – 용도 변경 약물(TACTIC-R): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-07-082022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] Administered Admission age Analysis Arm ARMS balloon pump balloon pump) Baricitinib baseline blinded Blinding calculated Cambridge Cambridge University Hospitals NHS Foundation Trust can not candidate cardiac clearance clinical picture college comparator comparison Complete COVID-19 infection creatinine creatinine clearance CRP Data analysis Data monitoring committee Day death defined determine diabetes Diagnosis discharge disease dissemination dose drug Drug evaluation Efficacy element enrolled envelope EU Clinical Trial EU Clinical Trials EudraCT event exclusion criteria feature fixed foundation Gault Gender hypertension IDMC immunomodulatory immunomodulatory drug immunomodulatory drugs Immunomodulatory therapies immunomodulatory therapy incidence include Inclusion independent data monitoring committee initial Inotropes interim analysis Intervention intravenously Invasive mechanical ventilation investigator ISRCTN late stage Local male membrane neutrophil Neutrophils NHS number objective on admission once daily Open-label open-label trial opinion Organ failure organ support outcome Oxygenation participant Patient phase Platform trial positive positive COVID-19 predicted Primary outcome progression Prophylaxis protocol Radiographic radiological randomisation randomised randomised controlled trial Ravulizumab recruited recruitment reduce reduced regimen Registered related disease renal renal failure Repurposed drugs risk Sample size scalability selected severity SOC stage 2 Standard of care status stratified Study protocol subject Support Toxicity treatment arm Trial Trial registration triggered Trust university university hospital Venous Thromboembolism website [DOI] 10.1186/s13063-020-04535-4 PMC 바로가기 [Article Type] Letter