The Janus Face of IL-33 Signaling in Tumor Development and Immune EscapeReview Published on 2021-06-302023-08-30 Journal: Cancers [Category] E형 간염, [키워드] Cancer immunotherapy cellular context IL-33 immune editing ST2 [DOI] 10.3390/cancers13133281 PMC 바로가기 [Article Type] Review
Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapyResearch Article Published on 2021-06-282022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] antibody antibody production Autoimmune disease B cells benefit blockade Cancer immunotherapy cancers CD4 CD44 CD8 Combination COVID-19 patient decrease Deleterious dose effectors examined expression HCQ Hydroxychloroquine Immune checkpoint blockade Immunotherapy increase in indicate infiltrating inhibited mice myeloid cells no effect patients PD-L1 promote Regulatory T cell rejection rheumatoid arthritis subset systemic lupus erythematosus T cell T cells Therapeutic benefit thymic treat Treatment Tregs tumor cells tumors vasculature [DOI] 10.1371/journal.pone.0251731 PMC 바로가기 [Article Type] Research Article
This is not a pipe – But how harmful is electronic cigarette smokeHighlights Published on 2021-06-042022-10-28 Journal: Biomedical journal [Category] COVID-19, MERS, SARS, [키워드] ACE2 Affect atherosclerotic Blood Brain Cancer immunotherapy Cell COVID-19 COVID-19 patient diagnose drug-resistant effort elderly patients Electronic cigarettes epilepsy epitope Epstein–Barr virus vaccine G6PD gastrointestinal system hormone Inflammatory response inhibit SARS-CoV-2 journal liver men and women noncoding RNA Perilla physical predict regulate risk SARS-CoV-2 SARS-CoV-2 mutations smoking stroke surgical Thyroid Vaccine Variation [DOI] 10.1016/j.bj.2021.05.006 PMC 바로가기 [Article Type] Highlights
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2Brief Communication Published on 2021-05-262022-10-04 Journal: Nature Medicine [Category] MERS, SARS, 변종, [키워드] administration adverse event anti-PD1 association blockade BNT162b2 Cancer Cancer immunotherapy Colon cancer Colorectal cancer coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine CRS cytokine level Cytokine release syndrome Diagnosis elevated evidenced favor Immune checkpoint inhibitors include inflammatory markers monotherapy mRNA mRNA vaccine mRNA vaccines occurred Patient Patients with cancer Pfizer-BioNTech raised reported RNA vaccines Support syndrome vaccination [DOI] 10.1038/s41591-021-01387-6 PMC 바로가기 [Article Type] Brief Communication
IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered SalmonellaIFN-γ 의존성 NK 세포 활성화는 조작된 살모넬라에 의한 전이 억제에 필수적이다.Article Published on 2021-05-052024-07-29 Journal: Nature Communications [Category] 살모넬라증, [키워드] Antimicrobial responses Bacterial techniques and applications Cancer immunotherapy Metastasis [DOI] 10.1038/s41467-021-22755-3 PMC 바로가기 [Article Type] Article
Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapyCOVID-19 및 암 면역 요법에서 공유된 염증 경로 및 치료 전략Article Published on 2021-05-012022-09-12 Journal: Journal for immunotherapy of cancer [Category] SARS, 진단, [키워드] acute respiratory distress adverse event Allogeneic anti-inflammatory drug Anti-inflammatory therapy antibody Antigen approach ARDS benefit Cancer immunotherapy caused Cell cells characterized chimeric circulating cytokines clinical trial Complication coronavirus COVID-19 CRS cytokine disease drug drugs Effect elevated Endothelial dysfunction exaggerated immune response Graft-versus-host disease help Hospitalization immune system Immunotherapy infection with SARS-CoV-2 Inflammation Inflammation mediators Inflammatory inflammatory pathway inhibiting interleukin-6 interstitial involved mechanism monoclonal antibody Mortality pathogenesis of COVID-19 pathway performed preliminary evidence reducing reduction in SARS-COV-2 infection stimulate suppress syndrome systematic review systemic manifestation therapeutic strategy therapy toxicities Toxicity Treatment trials triggered viral infection [DOI] 10.1136/jitc-2021-002392 PMC 바로가기 [Article Type] Article
The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer ImmunotherapyReview Published on 2021-04-132023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Cancer immunotherapy endothelial anergy lymphocyte exclusion lymphocyte exhaustion macrophages Metastasis T cells tumor microenvironment [DOI] 10.3389/fimmu.2021.654877 PMC 바로가기 [Article Type] Review
To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 for T Cell AnalysisTo Ki 또는 Not to Ki: T 세포 분석을 위한 Ki-67의 사용 및 잠재력 재평가Immunology Published on 2021-04-092022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] analyses Analysis analyzed Antigen antigen-specific CD8 T cells approach Autoimmune disease Autoimmune diseases blood sample can be used Cancer immunotherapy Care CD8 T cell CD8 T cells Cell cell cycle cells clonal expansion COVID-19 demonstrated diabetes DNA dye dual effective example excluded experimental work flow cytometric flow cytometry Health Health care healthy donors human peripheral blood identify immune infections infectious mononucleosis Ki-67 lab lymphocyte Lymphocytes marker mice offer organ-specific Patient Peripheral blood phenotypic Potential proliferation provide provoke re-evaluation staining T cell T cell proliferation T cells tissues Type 1 diabetes window [DOI] 10.3389/fimmu.2021.653974 PMC 바로가기 [Article Type] Immunology
Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm항-CD28 항체(TGN1412) 유발 사이토카인 폭풍 후 면역 재구성 및 임상 회복Clinical Trial Published on 2021-04-012022-08-31 Journal: Cancer immunology, immunotherapy : CII [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] adverse event adverse events antibody asymptomatic patients autoantibody Cancer immunotherapy CD28 CD4 CD8 cells clinical recovery clinical trial cognitive Cognitive deficits Concentration consequence COVID-19 cytokine Cytokine dysregulation cytokine release Cytokine release syndrome Cytokine storm Cytokines Day declined defined dendritic cell dendritic cells Depression described diagnosed dry gangrene dysregulation elevated Follow-up Gastrointestinal healthy volunteer IgE immune immune dysregulation Immune monitoring Immune-related adverse events (irAEs) immunopathology Immunotherapy infections initial irAEs irritability memory Mild-to-moderate mucosal naïve neutropenia observation one patient over Patient problem problems pruritus Psychological raynaud s phenomenon required serum cytokine serum cytokines subset suffered Symptom systemic symptoms T-cell T-cells T-regulatory cell T-regulatory cells targets TGN1412. Treatment undetectable [DOI] 10.1007/s00262-020-02725-2 PMC 바로가기 [Article Type] Clinical Trial
Rethinking the management of immune checkpoint inhibitor‐related adrenal insufficiency in cancer patients during the COVID‐19 pandemicReview Published on 2021-03-082022-10-31 Journal: Endocrinology, Diabetes & Metabolism [Category] COVID-19, [키워드] Adrenal insufficiency Autoimmune Cancer Cancer immunotherapy cancer patient cancer treatment Care Chemotherapy clinical experience Combination Complication coronavirus disease COVID‐19 COVID‐19 infection COVID‐19 develop dosing regimen Effect effective glucocorticoid Glucocorticoids greater iatrogenic immune Immune checkpoint inhibitor Immune checkpoint inhibitors impacted increase induce Infection inhibitor Interaction Intersection management Mortality oncology pandemic Patient patients patients treated presenting question raised recommendation Result Rethinking risk SARS‐CoV‐2 Sepsis severity susceptibility Symptom syndrome the timing therapy treat Treatment worsening [DOI] 10.1002/edm2.246 PMC 바로가기 [Article Type] Review