The impact of COVID-19 on the cascade of care of HCV in the US and China미국과 중국의 HCV 치료에 대한 COVID-19의 영향Article Published on 2022-05-012022-09-11 Journal: Annals of hepatology [Category] 치료제, [키워드] affected Care carried cascade China Compliance continuum Course COVID COVID-19 COVID-19 pandemic cure rate decrease determine Direct-acting antivirals HCV HCV care continuum health system Hepatitis increase in Increased Laboratory material Nanjing pandemic Patient patients proportion proportions RNA significant decrease significantly Telemedicine therapy Treatment utilization Viral hepatitis Viral hepatitis elimination. [DOI] 10.1016/j.aohep.2022.100685 PMC 바로가기 [Article Type] Article
CASCADE: Naked eye-detection of SARS-CoV-2 using Cas13a and gold nanoparticlesCASCADE: Cas13a와 금 나노입자를 이용한 SARS-CoV-2 육안 탐지Article Published on 2022-05-012022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acid activate aggregation approach approaches cascade cleave clinical sample clinical samples Concentration COVID-19 pandemic CRISPR CRISPR/Cas13 detect Diagnosis diagnostics Diseases effort gold Gold nanoparticle Gold nanoparticles Infectious diseases isothermal isothermal amplification molecular Naked-eye nanomaterials NASBA nasopharyngeal swabs nucleic acid nucleic acid amplification nucleic acids oligonucleotide Pathogens point-of-care Prevent Protein RNA RNase RPA SARS-CoV-2 SARS-CoV-2 RNA Scientific community sensitivity Spread ssRNA variety Viral viral nucleic acids Viral RNA [DOI] 10.1016/j.aca.2022.339749 PMC 바로가기 [Article Type] Article
Can Panax ginseng help control cytokine storm in COVID-19?Review article Published on 2022-05-012022-10-05 Journal: Journal of Ginseng Research [Category] 치료제, [키워드] activities acute respiratory syndrome antiviral drug approach article Can cascade caused conditions coronavirus Coronavirus disease 2019 COVID-19 cytokine production Cytokine storm drug Effect Effectiveness Efficiency Evidence help induce innate immune response medication Mild Moderate COVID-19 molnupiravir Panax ginseng pandemic Paxlovid positive pro-inflammatory cytokine Ritonavir SARS-CoV-2 SARS-CoV-2 variants searched Side effects Therapeutic strategies treat Treatment [DOI] 10.1016/j.jgr.2022.02.006 [Article Type] Review article
Optimization of a new adaptive intervention using the SMART Design to increase COVID-19 testing among people at high risk in an urban communitySMART 디자인을 사용한 새로운 적응형 개입 최적화Randomized Controlled Trial Published on 2022-04-142022-09-11 Journal: Trials [Category] 변종, 임상, [키워드] adaptive adhere affected Analysis baseline booster Brief counseling cascade CDC center co-morbidities Community Complete completion Contact tracing continuum Control counseling COVID-19 COVID-19 testing COVID-19 treatment cascade COVID-19 vaccination Critical Critical dialog deaths determinant effective exposure to Factor Families Follow-up Health help herd immunity high risk high-risk population HIV HIV prevention Hospitalization identify Immunity impacted incarceration individual Intervention media morbidities Multiple Navigation services New optimization participant poverty predictor prevention protocol public health quarantine Randomized receive recommendation recommendations recruited reduce Sequential Multiple Assignment Randomized Trials (SMART). SmaRT social determinants social distancing social media state Stigmatization Treatment USA vaccination Vaccine variants variety while with COVID-19 [DOI] 10.1186/s13063-022-06216-w PMC 바로가기 [Article Type] Randomized Controlled Trial
Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chipArticle Published on 2022-04-082022-10-04 Journal: Nature Communications [Category] 바이오마커, 변종, 치료제, [키워드] activating Activation Antimicrobial responses Apoptosis attenuate cascade Cell circulating contribute cytokine deformation disease endothelial cells epithelial facilitate H3N2 infection host innate immunity host response human lung immune cells induce Inflammation Inflammatory response Influenza influenza infection inhibitor innate immune response Innate immunity life-threatening lung Lung inflammation Mechanical pandemic Patient physical potential therapeutic target Protective RAGE receptor recruitment reveal Signaling suppress target therapeutic intervention tissue engineering TRPV4 viral burden viral infection viral replication virus [DOI] 10.1038/s41467-022-29562-4 PMC 바로가기 [Article Type] Article
A comparison of office-based buprenorphine treatment outcomes in Bronx community clinics before versus during the COVID-19 pandemicResearch article Published on 2022-04-012022-10-05 Journal: Journal of substance abuse treatment [Category] COVID19(2023년), SARS, 치료법, [키워드] age Buprenorphine Care cascade Cascade of care change changes Characteristics clinics Community COVID-19 pandemic death deaths disorder examined Hispanic initiated maintain male medical record medication New York City Opioid use disorder outcome outcomes overdoses pandemic Patient Policy public health emergency reduced reduction Regulation Result retained retrospective cohort study significant difference T-tests Treatment Treatment outcome worsening [DOI] 10.1016/j.jsat.2021.108641 [Article Type] Research article
Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascadeShort communication Published on 2022-04-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] 신약개발, [키워드] acute lung injury ameliorated attenuate cascade cytoplasmic drug escitalopram HDAC4 IC50 infiltration Inflammatory responses inhibited inhibiting investigated Lung injury mice morbidity and mortality neutrophil NF-κB signaling nucleus p65 pathway pro-inflammatory cytokine promoted pulmonary injury reduced SIK2 translocated Treatment triggered [DOI] 10.1016/j.bbrc.2022.02.015 [Article Type] Short communication
Therapeutic potential of induced iron depletion using iron chelators in Covid-19Review article Published on 2022-04-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘, 치료제, [키워드] Administered antioxidants Antiviral approved benefit cascade Clinical use Corticosteroids COVID 19 COVID-19 Critically ill patient effective FDA ferritin ferritin levels Genomics heavy chain Hyperferritinemia immunomodulators include Inflammation inflammatory markers intravenous iron Iron Chelator lactoferrin men metabolism monoclonal antibodies Pathogenesis poor prognosis proportion Proteomic interaction responsible signaling molecules the patient therapy tissue tissues treat Treatment women [DOI] 10.1016/j.sjbs.2021.11.061 [Article Type] Review article
Reimagining the status quo: How close are we to rapid sputum-free tuberculosis diagnostics for all?현상 유지: 우리는 모두를 위한 가래 없는 신속한 결핵 진단에 얼마나 근접하고 있습니까?Review Published on 2022-04-012022-09-11 Journal: EBioMedicine [Category] MERS, 진단, 치료제, [키워드] Active disease Affect applied artificial intelligence automated capillary blood Care cascade Chest complement confirmation COVID-19 Critical diagnosed Diagnosis diagnostic diagnostics difficulty evaluate expand help Innovation lack limitation Non-sputum point-of-care Radiography Rapid reducing Reference standards researcher resource sputum TB patient Triage Tuberculosis urgency [DOI] 10.1016/j.ebiom.2022.103939 PMC 바로가기 [Article Type] Review
Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19세로형 플라즈마 단백질체학 분석, 급성 코로나19에서 새로운 후보 바이오마커 밝혀Article Published on 2022-04-012022-09-11 Journal: Journal of Proteome Research [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] abundance ACEi acquisition Activation acute COVID-19 acute inflammatory response Admission amyloid Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors ARB baseline Blood blood plasma candidate cascade cell proliferation complement Complement activation COVID-19 COVID-19 patients decrease degranulation exposure to fluctuation followed by fructose functions healthy control healthy controls healthy individual healthy individuals host response humoral immune response Infection Inflammatory Inflammatory response inhibitors longitudinal longitudinal analysis mechanism mechanisms nonsurvivors novel on admission pathophysiology Patient patients Platelet profile Protein Proteins proteomic proteomics Quantitative Receptor Blockers Regulation smooth muscle survivor targeted quantitative proteomics. [DOI] 10.1021/acs.jproteome.1c00863 PMC 바로가기 [Article Type] Article