Single‐cell RNA sequencing identify SDCBP in ACE2‐positive bronchial epithelial cells negatively correlates with COVID‐19 severity단일 세포 RNA 시퀀싱은 ACE2 양성 기관지 상피 세포에서 SDCBP를 식별하여 COVID-19 중증도와 음의 상관 관계가 있습니다Original Article Published on 2021-06-162022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin antigen processing Antigen processing and presentation assist B cells BALF biopsy bronchial epithelial cell bronchial epithelial cells Bronchoalveolar lavage fluid caused CD4+ T cells CD74 CD8+ T cells Cell cell type coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patients COVID‐19 death dendritic cell dendritic cells Diagnosis diagnostic enzyme epithelial cells expansion expression Genes Host hosts Hsp90 HSP90AA1 HSP90AB1 HuRI (human reference interactome) identify immune infiltration lung lung biopsies lung carcinoma macrophages mechanism Mild disease mitigate neutrophil Neutrophils pathway Patient positively correlated prognostic biomarker respiratory RNA sequencing SARS‐CoV‐2 SDCBP SDCBP (Syndecan‐Binding Protein) severe symptoms severity subsequent T cells therapeutic target therapeutic targets tissues Treatment was increased WGCNA (weighted gene co expression network analysis) with mild disease [DOI] 10.1111/jcmm.16714 PMC 바로가기 [Article Type] Original Article
PD-L1 Dysregulation in COVID-19 PatientsImmunology Published on 2021-06-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adaptive immune response ARDS biological sample blood sample caused CD4+ T cells clinical study consequence COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient cultures dysregulated dysregulated immune response dysregulation effective epithelial cell Evidence healthy donors healthy individuals hospitalized COVID-19 patient Host immune response identify Immune cell immune checkpoint molecules in vitro Infection inhibitors innate immune response Ligand manifestation Manifestations model system modulation Monocytes Neutrophils Patient PD-L1 Prognosis prognostic prognostic biomarker reached RNA expression SARS-CoV-2 Serum level subset T cell therapeutic approaches tissue tissue biopsy upregulation variety [DOI] 10.3389/fimmu.2021.695242 PMC 바로가기 [Article Type] Immunology
Association of Clinical and Immunological Characteristics With Disease Severity and Outcomes in 211 Patients With COVID-19 in Wuhan, ChinaCellular and Infection Microbiology Published on 2021-05-282022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] Admission age Analysis B cells body temperature CD4+ T cells CD8+ T cell changes in clinical Clinical characteristics Clinical outcome clinician Comorbidities Comorbidity Coronavirus disease 2019 COVID-19 COVID-19 patients CREA creatinine Critical disease deterioration Disease progression disease severity duration of fever effective intervention expression feature functions global public health higher risk Hospital stay identify IL-6 immunological immunological characteristics indicated information Laboratory liver Logistic lymphocyte lymphocyte counts lymphopenia Male sex median age non-severe cases non-severe patient non-severe patients Older age Patient patients with COVID-19 peripheral lymphocyte predominant presenting progression recruited renal Result risk risk factor selective serum Serum level Severe case severe cases Severe patient severe patients significantly subpopulations subset sustained fever Symptom university WBC White blood cell with COVID-19 Wuhan Wuhan, China [DOI] 10.3389/fcimb.2021.667487 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Cellular and plasma proteomic determinants of COVID-19 and non-COVID-19 pulmonary diseases relative to healthy aging Research Published on 2021-05-112022-10-05 Journal: Nature Aging [Category] 치료법, [키워드] age aging B cells Blood CD4+ T cell CD4+ T cells CD8+ T cell cell population cellular change coronavirus disease correlated COVID-19 creatinine Cytometry determinant disease disease-associated healthy healthy donor individual individuals with COVID-19 moderate Non-COVID-19 physiological plasma Protein Proteins proteomic pulmonary disease Secretome severity T cell unique urea nitrogen with COVID-19 [DOI] 10.1038/s43587-021-00067-x [Article Type] Research
Investigation of immune cells on elimination of pulmonary-Infected COVID-19 and important role of innate immunity, phagocytes폐감염 COVID-19 제거에 대한 면역세포의 연구와 선천면역, 식세포의 중요한 역할Review Published on 2021-03-012022-09-12 Journal: Reviews in Medical Virology [Category] 진단, [키워드] Activation acute phase Adaptive immune response Adults alleviate antibody B cell cause CD4+ T cell CD4+ T cells children contribute COVID-19 COVID-19 infection Factor IgM and IgG Immune cell immune system Infection innate immune system Innate immunity investigation Mild much higher observation Patient patients phagocyte producing PROTECT required vaccination vaccine for COVID-19 white [DOI] 10.1002/rmv.2158 PMC 바로가기 [Article Type] Review
Deciphering the COVID-19 cytokine storm: Systematic review and meta-analysisMeta-Analysis Published on 2021-01-012023-07-12 Journal: European Journal of Clinical Investigation [Category] SARS, [키워드] CD4+ T cells CD8+ T cells COVID-19 Cytokine storm Novel coronavirus SARS-CoV-2 [DOI] 10.1111/eci.13429 PMC 바로가기 [Article Type] Meta-Analysis
HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID PatientsImmunology Published on 2020-12-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Anti-viral Antibody Response CD4+ cell CD4+ T cell CD4+ T cells CD8+ cell Cell characterized common variable immunodeficiency disorder (CVID) Coronavirus disease 2019 (COVID-19) correlation COVID-19 cross-reactive cross-reactivity CVID detectable Endemic evaluate evaluated Evidence Frequency had no HCoV-229E healthy control healthy individuals human endemic coronavirus 229E (HCoV-229E) human endemic coronavirus OC-43 (HCoV-OC43) IFNγ IL-2 Immunity less marker multifunctional nucleocapsid pathogen Patient patients patients with CVID peptide pools primary immunodeficiency (PID) profiles Protective Proteins provide raised reactive reactivity reported risk SARS-CoV-2 SARS-COV-2 infection Seven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severity T cell T cell response T cell responses TNFα virus [DOI] 10.3389/fimmu.2020.607918 PMC 바로가기 [Article Type] Immunology
Maturation of T and B Lymphocytes in the Assessment of the Immune Status in COVID-19 PatientsArticle Published on 2020-12-052022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] assessment B cells maturation CD4+ CD4+ cell CD4+ cells CD4+ T cells CD8+ T cell Cell central memory central memory CD4+ change chest X-ray COVID-19 COVID-19 patient COVID-19 patients effector CD8+ cells evaluate flow cytometry healthy control immunological profile interstitial lesion leukocyte lymphocyte maturation naïve novel coronavirus disease Patient patients patients with COVID-19 plasmablast plasmablasts proportion selected significantly higher status study group T cell T cells maturation T lymphocyte Topic was performed X-ray [DOI] 10.3390/cells9122615 PMC 바로가기 [Article Type] Article
Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patientsClinical Trial Published on 2020-12-012023-07-12 Journal: European Journal of Immunology [Category] SARS, [키워드] Antibody Response CD4+ T cells COVID-19 IgG SARS-CoV-2 [DOI] 10.1002/eji.202048908 [Article Type] Clinical Trial
Associations of medications used during hospitalization and immunological changes in patients with COVID-19 during 3-month follow-up입원 중 사용한 약물과 3개월 추적관찰 중 코로나19 환자의 면역학적 변화의 연관성Article Published on 2020-12-012022-09-11 Journal: International immunopharmacology [Category] MERS, SARS, 진단, 치료제, [키워드] antibiotic use association CD3+ CD4+ CD4+ T cell CD4+ T cells CD8+ T cells changes in China completion COVID-19 COVID-19 patient COVID-19 patients declined decrease demonstrated discharge enrolled evaluate Follow-up glucocorticoid herd immunity Hospitalization IgG IgG and IgM IgM Immunity immunoglobulins immunological change immunological changes Immunological response immunological responses Increases increases in IQR Linear regressions median medication medications men Patient patients with COVID-19 positive rate positive rates Regression retrospective cohort study screened significantly increased T cell T cells understanding Vaccine was performed were used Wilcoxon signed-rank test with COVID-19 women [DOI] 10.1016/j.intimp.2020.107121 PMC 바로가기 [Article Type] Article