Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients’
중증 COVID-19 환자에서 IL6R의 다형성과 상대적 IL6 상승의 잠재적 상관 관계 평가
Clinical Trial
[키워드] Affect
affecting
Analysis
Assessing
association
baseline
Baseline assessment
baseline level
blood sample
Blood samples
clinical response
Clinical studies
clinical study
clinical variable
collected
Combination
Control
correlation
COVID-19
COVID-19 patient
COVID-19 patients
COVID19
COVID19 patients
cytokine level
cytokine levels
Cytokine storm
defined
determine
elevated
Elevation
Genetic
Genetic variant
genetic variants
Glucose
help
highest
hospitalized COVID-19 patient
hospitalized COVID-19 patients
hospitalized patient
hospitalized patients
identify
IL-6
IL-6 inhibition
IL-6 level
IL-6 levels
IL6
IL6R
interleukin-6
Interpretation
mild COVID-19 patient
Mortality
norm
not seen
outcome
oxygen
P-value
p-value < 0.01
Participants
pathophysiology
patient population
patients
Phase 3
Placebo
plasma
Plasma levels
Pneumonia
polymorphism
randomized study
receiving
Regulatory
report
robust
rs2228145
Sequencing analysis
serum
severe and mild COVID-19 patients
severe COVID-19
severe patients
severity
shown
significantly
significantly increased
supplemental oxygen support
tested
the patient
tradipitant
Treatment
unlikely
variant
variants
were measured
while
WHO
whole genome
Whole genome sequencing
[DOI] 10.1016/j.cyto.2021.155662 PMC 바로가기 [Article Type] Clinical Trial
[DOI] 10.1016/j.cyto.2021.155662 PMC 바로가기 [Article Type] Clinical Trial