Justificativa e Desenho do Ensaio Clínico Randomizado COVID-19 Outpatient Prevention Evaluation (COPE – Coalition V): Hidroxicloroquina vs. Placebo em Pacientes Não HospitalizadosRandomized Controlled Trial Published on 2022-02-142022-10-04 Journal: Arquivos Brasileiros de Cardiologia [Category] COVID19(2023년), Fulltext, SARS, 임상, [키워드] A p-value analyses assigned benefit blinded Care chronic obstructive clinical clinical setting Coalition COPE coronavirus disease COVID-19 criteria desfecho primário diabete double-blind Effectiveness eficácia Ensaio Clínico Controlado Aleatório evaluate Evidence HCQ Hidroxicloroquina Hospitalization Hydroxychloroquine hypothesis test independent individuals with COVID-19 intention-to-treat principle knowledge largest trial lung matching placebo Mild symptom multicêntrico obesity objective outcome Outpatient patients Placebo placebo-controlled clinical trial Pragmatic pragmático Prevent prevention primary efficacy endpoint Primary outcome pulmonary disease question randomizado randomization Randomized Randomized controlled trial randomized study Result risk factor SARS-CoV-2 seeking specific treatment statistically significant symptom onset therapeutic option treatment groups two-sided with COVID-19 [DOI] 10.36660/abc.20210832 PMC 바로가기 [Article Type] Randomized Controlled Trial
Blood GFAP as an emerging biomarker in brain and spinal cord disorders Reviews Published on 2022-02-032022-10-05 Journal: Nature reviews. Neurology [Category] 바이오마커, [키워드] accelerated Acidic Algorithm Biomarker Blood Brain can be used clinical setting Clinical severity Clinical use CNS Concentration condition contribute correlated detect Diagnosis diagnosis and monitoring disease disorder Evidence FDA GFAp immunoassay Implications indicate individual Injury limitation marker measure Mild MOST multiple sclerosis Neurological diseases Neurological disorders pathology platform point-of-care Precision Protein rapid increase review stroke utility widespread worsening [DOI] 10.1038/s41582-021-00616-3 [Article Type] Reviews
Telemedicine in Cardiology: Modern Technologies to Improve Cardiovascular Patients’ Outcomes—A Narrative Review심장의 원격 의료: 심혈관 환자의 결과를 개선하기 위한 현대 기술 - 내러티브 검토Review Published on 2022-02-012022-09-10 Journal: Medicina [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] addition approach arrythmia benefit best cardiological Cardiology cardiovascular clinical setting Contact contact with COVID-19 outbreak current Data processing Diagnosis diagnostics direct contact Evidence evidence of example expressed Healthcare professional healthcare professionals Healthcare system Healthcare systems heart failure include instance Ischemia lack less monitoring narrative Patient physical Registration remote review solution standard care subjects technology Telemedicine Treatment [DOI] 10.3390/medicina58020210 PMC 바로가기 [Article Type] Review
Effectiveness of Monoclonal Antibodies in Preventing Severe COVID-19 With Emergence of the Delta Variant델타 변이체의 출현으로 심각한 COVID-19를 예방하는 모노클로날 항체의 효과Article Published on 2022-02-012022-09-11 Journal: Mayo Clinic proceedings [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% CI adjusted Alpha Anti-spike anti-spike monoclonal antibodies anti-spike monoclonal antibody approved Beta Beta variant beta variants can not Charlson Comorbidity Index clinical setting Cohort Comorbidity COVID-19 death Delta delta variant effective strategy Effectiveness Efficacy emergence epoch excluded higher odd higher odds Hospitalization infused maintain monoclonal monoclonal antibodies monoclonal antibody Odds ratio outcome Patient predominant Preventing question retrospective cohort severe disease Severe infection the SARS-CoV-2 Treatment variant virulent [DOI] 10.1016/j.mayocp.2021.12.002 PMC 바로가기 [Article Type] Article
Promising Assays for Examining a Putative Role of Ribosomal Heterogeneity in COVID-19 Susceptibility and SeverityReview Published on 2022-01-282022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] analyses Antiviral treatment arise assays for proteins assays for RNA sequence and structure caused Characteristics characterized clinical sample clinical setting component concurrent COVID-19 COVID-19 disease Critical detect droplet Efficacy element environmental cues Examining generate heterogeneity Host host susceptibility identify include Infection Messenger RNA modifications mRNA Nanopore organism post-translational modification protocol responses ribosomal heterogeneity ribosomal protein ribosomal proteins ribosomal RNA ribosomal RNAs ribosome ribosomes RNA genome RNA sequencing role rRNA rRNAs SARS-CoV-2 SARS-CoV-2 coronavirus selected sequence Sequencing severity of symptoms Side effect Single Cell Statistical power structural variations structures substrate Symptoms the disease the SARS-CoV-2 transcript translate translation translation machinery translational Transmissibility unique vaccine immunogenicity vaccine response variant viral infectivity [DOI] 10.3390/life12020203 PMC 바로가기 [Article Type] Review
Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19Research Article Published on 2022-01-272022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] Admission age analyzed Asymptomatic biochemical cause clinical endpoint Clinical outcome clinical setting Control control patients cumulative death develop duration of symptom Effect Efficacy evaluate exposure to hospital ICU admission improvement in vitro In-hospital inflammatory parameters Laboratory laboratory parameter less lung infiltrate lung infiltrates lymphocyte monocyte multicenter Multivariate analysis no difference Non-COVID-19 outcome Patient patients hospitalized Protective pulmonary infiltrate receiving Result Retrospective study SARS-COV-2 infection serious COVID-19 severity Sex shown survival Treatment two groups Valproic acid were recorded with COVID-19 worsening [DOI] 10.1371/journal.pone.0262777 PMC 바로가기 [Article Type] Research Article
Diagnostic accuracy of three commercially available one step RT-PCR assays for the detection of SARS-CoV-2 in resource limited settingsResource Limited 설정에서 SARS-COV-2의 검출을위한 3 개의 상업적으로 이용 가능한 1 단계 RT-PCR 분석의 진단 정확도Research Article Published on 2022-01-202022-09-10 Journal: PLoS ONE [Category] 진단, 치료기술, [키워드] 95% CI absence adjust agreement alternatives amplification analyzed assays Bayesian BGI Chain Reaction clinical setting Community comparable conducted Contact COVID-19 cross-sectional cross-sectional study determined by diagnostic Diagnostic accuracy diagnostic sensitivities diagnostic test diagnostic tests Early detection effort estimate evaluate gold gold standard help Interpretation kappa values latent class pandemic polymerase chain reaction positive Prevalence public health Quality reported resource respiratory Respiratory samples Result reverse transcriptase RNA RT-PCR RT-PCR assay RT-PCRs SARS-CoV-2 sensitivities sensitivity Specificities specificity Support Surveillance Swab tested the WHO was done while [DOI] 10.1371/journal.pone.0262178 PMC 바로가기 [Article Type] Research Article
Antibody Responses to BNT162b2 Vaccination in Japan: Monitoring Vaccine Efficacy by Measuring IgG Antibodies against the Receptor-Binding Domain of SARS-CoV-2Research Article Published on 2022-01-192022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, [키워드] acute respiratory syndrome age analyzed antibody antibody isotype antibody production Antibody Response BNT162b2 BNT162b2 vaccine cause clinical setting Cohort coronavirus coronavirus disease correlated correlation COVID-19 detect determine dose Efficacy enzyme enzyme-linked immunosorbent Factors female Gender high correlation hypertension IgA IgG IgG level IgM immunoassay individual individuals information Japan Japanese Laboratory levels of antibodies males mass vaccination MONITOR monitoring mRNA vaccine negative correlation Neutralizing activity of BNT162b2 powerful tool predict provide RBD reported response SARS-CoV-2 SARS-CoV-2 vaccination second dose second vaccination sera Serological assay significantly significantly higher the receptor-binding domain vaccinated individual vaccination Vaccination strategy Vaccine was measured were measured [DOI] 10.1128/spectrum.01181-21 PMC 바로가기 [Article Type] Research Article
Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical TrialsReview Published on 2022-01-072022-10-30 Journal: Nutrients [Category] COVID-19, [키워드] addition anti-inflammatory cytokines Biomarker clinical Clinical outcome clinical setting clinical study cohorts of patient Compound compounds COVID-19 COVID-19 disease COVID-19 patients Curcumin Cytokine storm database deaths decrease driving duration of hospitalization Effect effective Efficacy help highlight IL-10 IL1β IL6 increase in Intervention Mild offer outcomes OVID profile Proinflammatory cytokine ProQuest review Safe SARS-CoV-2 searched severe COVID-19 severe COVID-19 patients significant decrease suggested Symptoms systematic review thought Treatment vaccination Web of Science [DOI] 10.3390/nu14020256 PMC 바로가기 [Article Type] Review
A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain)SARS-CoV-2와 함께하는 1년: 바르셀로나 시(스페인 카탈로니아)에서 전체 게놈 시퀀싱을 통한 바이러스 계통 순환의 역학 개요Coronaviruses Published on 2022-01-042022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] age antigenic B.1.1 B.1.1.7 B.1.177 B.1.351 B.1.617.2 Barcelona Catalonia circulating circulation clinical setting Complete consensus sequence consensus sequences COVID-19 D614G mutation E484K epidemiological events Genetic genetic diversity genetic variability GISAID hospital Illumina immunological L452R Lineage lineages MiSeq Molecular epidemiology Multiple Mutation N-terminal domain P.1 pandemic predominant primary care protocol Randomly Receptor-binding domain respiratory respiratory sample S protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 virus selected sequenced Spain T478K the receptor-binding domain the S protein vaccination variants viruses was performed were used WGS while whole-genome sequencing [DOI] 10.1080/22221751.2021.2011617 PMC 바로가기 [Article Type] Coronaviruses