compassionate use

[키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory distress syndrome (ARDS) Administered administration ALT, alanine aminotransferase ARDS, acute respiratory distress syndrome AST, aspartate aminotransferase BID, bis in die (twice a day) block CCL2, chemokine C–C motif ligand 2 CCL3, chemokine C–C motif ligand 3 CCL4, chemokine C–C motif ligand 4 CCL5 CCL5, chemokine C–C motif ligand 5 CCR1, C–C chemokine receptor type 1 CCR5 CCR5, C–C chemokine receptor type 5 CD4/CD8 CDC, Centers for Disease Control chemokine Chemokine receptor CK, creatine kinase clinical trial clinically compassionate use Complication confirmed case COPD, Chronic obstructive pulmonary disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19, Coronavirus disease 2019 Critically ill Critically ill patient CRP, C-reactive protein CXCL10, chemokine C-X-C motif ligand 10 CXCL2, chemokine C-X-C motif ligand 2 cytokine deaths decrease died Disruption DPP4, dipeptidyl peptidase-4 DVT, deep vein thrombosis dysregulated EDTA, ethylenediaminetetraacetic acid effective eIND, emergency investigational new drug application elevated end-organ damage FDA, Food and Drug Administration Fi0_2, fraction of inspired oxygen, IgG4 Hemodialysis hemophagocytic lymphohistiocytosis, HTN Host immune response humanized Hydroxychloroquine, HLH hypertension, ICU IgG4 IL-6 immune dysregulation immune function immune system immunoglobulin G4, HCQ infection with SARS-CoV-2 inflammatory cell initial intensive care intensive care unit, IL-1β interferon gamma-inducible protein (IP) 10 or CXCL10, LOA interferon gamma, IL-6 interleukin 1 beta, IFN-ƴ interleukin 6, IP-10 Leronlimab (PRO 140) letter of authorization, MCP Ligand macrophage colony stimulating factor, MDC (CCL22) macrophage colony-stimulating factor encoded by the CCL22 gene, MERS-CoV macrophage Inflammatory Proteins 1-alpha, MIP-1β macrophage Inflammatory Proteins 1-beta, N/A macrophages mechanical ventilation Middle East respiratory syndrome coronavirus, MIG monoclonal antibody monocyte chemoattractant protein, M-CSF monokine induced by IFN-γ (interferon gamma), MIP-1α morbidity and mortality National Early Warning Score, NK natural killer, OSA normalized not applicable, NEWS2 obstructive sleep apnea, PDGF-AA pathogenic Patient per os (taken by mouth), RANTES plasma platelet-derived growth factor AA, PDGF-AA/BB platelet-derived growth factor AA/BB, PEEP positive end-expiratory pressure, PNA pulmonary nodular amyloidosis, po receptor reduce regulated on activation, normal T expressed and secreted (also known as CCL5) responsible RO, receptor occupancy RT–PCR, reverse transcriptase polymerase chain reaction SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus severe COVID-19 shown Signaling statistically significant surgical survival T cell T-reg RO, regulatory T cells – receptor occupancy TGF- α, transforming growth factor alpha the cytokine storm the patient thought TNF-α, tumor necrosis factor alpha TNF-β, tumor necrosis factor beta treat treated Treatment Tregs, regulatory T cells vasopressor support VEGF-A, vascular endothelial growth factor A virus WBC, White blood cell WHO, World Health Organization
[DOI] 10.1016/j.jtauto.2021.100083 PMC 바로가기 [Article Type] Review article