Serverless computing in omics data analysis and integrationomics 데이터 분석 및 통합의 서버리스 컴퓨팅Article Published on 2022-01-172022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] accelerated Analysis applicability approaches as required automatically bioinformatics cloud computing complex comprehensive analysis computational resource configuration container container-as-a-service COVID-19 pandemic Data analysis Data processing evaluate function-as-a-service integration Integrative analysis maintenance management offer omics data integration omics data processing Planning platform provide required resource serverless computing. [DOI] 10.1093/bib/bbab349 PMC 바로가기 [Article Type] Article
Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatmentArticle Published on 2022-01-142022-10-04 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] 95%CI added adjusted administration Admission age APACHE II APACHE II score association Belgium Better chronic Comorbidities comparable comprehensive analysis coronavirus 2 country COVID-19 disease course disease severity Diseases Factor female females Germany ICU independent intensive care unit investigated less Logistic regression male mechanism Medical research Model Modification Mortality multicenter Netherlands no effect obese obesity Observational cohort study Odds ratio organ support other variables pandemic Pathogenesis Patient patients patients with SARS-CoV-2 Physiology Pneumonia prognostic random intercept respiratory Risk factors SARS-CoV-2 SARS-CoV-2 patient Seven Sex smoking survival Therapeutic approach therapy Treatment was used [DOI] 10.1038/s41598-021-04531-x PMC 바로가기 [Article Type] Article
Encapsulated hydroxychloroquine and chloroquine into cyclic oligosaccharides are the potential therapeutics for COVID-19: insights from first-principles calculationsResearch article Published on 2022-01-012022-10-05 Journal: Journal of Molecular Structure [Category] 신약개발, [키워드] Analysis antiviral therapy blistering caused Chest Chloroquine complexes comprehensive analysis coronavirus cough COVID-19 COVID-19 main chain protease COVID-19 pandemic cytotoxicity develop diarrhea drug drugs effective HCQ help Hydroxychloroquine Infection macromolecule modulating molecular molecular docking molecular dynamics Novel coronavirus offer oligosaccharide optical Pain peeling reduce researcher SARS-CoV-2 Scientific community Side effect stability Still Tablet TDDFT Treatment treatment strategy Trial virus worldwide pandemic [DOI] 10.1016/j.molstruc.2021.131371 [Article Type] Research article
Integrated analysis of circulating immune cellular and soluble mediators reveals specific COVID19 signatures at hospital admission with utility for prediction of clinical outcomes순환 면역 세포 및 가용성 매개체의 통합 분석Research Paper Published on 2022-01-012022-09-10 Journal: Theranostics [Category] 바이오마커, [키워드] activated activating adaptive addition Analysis analyzed asymptomatic infection Blood caused CCL2 CCL8 CD8+ Cell cellular chemokine chemokines circulating clinical manifestation clinical manifestations Clinical outcome Clustering cold-like symptom cold-like symptoms complex comprehensive analysis coronavirus disease Coronavirus disease 2019 correlated COVID19 COVID19 patient COVID19 patients Critical care CXCL10 CXCL9 Cytokines deregulated disease disease course disease severity exacerbated experimental variable expressing expression Extracellular Frequency GzmA GzmB healthy donors heterogeneous Hospital admission Hospitalization Host immune response IFNα IL18 IL1RA IL2 IL31 IL36B immune immune response immune signature immunological IMPROVE Infection Inflammation Inflammatory cytokine Inflammatory cytokines Inflammatory factor LAG3 Ligand ligands MIC Mild monocyte Monocytes Multivariate analysis NK cell NK cells NKG2D organ damage Patient PD1 predict Prognosis receptor reduction respiratory respiratory tract infection Respiratory tract infections reveal risk of death SARS-CoV-2 Sepsis Severe case similarity subset TNFα ULBP utility variety [DOI] 10.7150/thno.63463 PMC 바로가기 [Article Type] Research Paper
Protocol of investigation into reporting quality of RCT abstracts on COVID-19 pursuant to CONSORT (CoCo study)—a reviewCONSORT(CoCo 연구)에 따른 COVID-19에 대한 RCT 초록의 보고 품질에 대한 조사 프로토콜 - 검토Study Protocol Published on 2021-12-242022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] Abstract abstracts accelerated activity checked Cochrane Library Completeness comprehensive analysis CONSORT CONSORT checklist CONSORT statement contribute coronavirus COVID-19 COVID-19 pandemic COVID-19 RCT COVID-19 RCTs criteria criticism debate emergency situation English examined expected Frequency include information investigated less manuscript Medical research object offer peer review primary endpoint RCT RCTs Registration reported Reporting Reporting quality required Research RTC SARS-CoV-2 Study design subject Support Therapies Transparency urgency [DOI] 10.1186/s13063-021-05937-8 PMC 바로가기 [Article Type] Study Protocol
Epidemiological characteristics of COVID-19 travel-associated cases in Vojvodina, Serbia, during 2020Research Article Published on 2021-12-232022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age Ageusia Anosmia Characteristics Clinical outcome Comorbidities Comorbidity comprehensive analysis conducted contributed Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 disease cross-sectional database develop diabete Diagnosis epidemiological Evidence Germany groups hypertension increasing age International laboratory confirmation majority Male sex Older Patient Pneumonia predictor protective factor Public public health Surveillance symptoms onset Travel were recorded women [DOI] 10.1371/journal.pone.0261840 PMC 바로가기 [Article Type] Research Article
Promising Antiviral Activity of Agrimonia pilosa Phytochemicals against Severe Acute Respiratory Syndrome Coronavirus 2 Supported with In Vivo Mice StudyArticle Published on 2021-12-162022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] abnormality ABTS activity acute lung injury acute respiratory syndrome addition Adsorption Agrimonia pilosa ALI antioxidant antiviral activity Apoptosis assays caspase-3 caused clinical trials Compound comprehensive analysis conducted coronavirus coronavirus 2 coumarin COVID-19 pandemic disease downregulation DPPH Effect evidenced exhibited expression Gene Expression histopathological IL-18 IL-1β IL-6 immunomodulatory immunomodulatory activity Inflammation investigated LC-ESI-MS/MS lipopolysaccharide LPS lung tissue mechanism of action mice mononuclear cells MPO NF-κB oxidative stress patients with COVID-19 Peripheral blood phytochemical plaque reduction protective effect respiratory SARS-CoV-2 scavenging serum TAC therapeutic compound TLR-4 TNF-α Treatment upregulation virucidal were assessed [DOI] 10.3390/ph14121313 PMC 바로가기 [Article Type] Article
Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunctionMIS-C 환자의 단백질체 프로파일링은 인터페론 감마 조절 장애 및 혈관 내피 기능 장애와 관련된 이질성을 나타냅니다.Article Published on 2021-12-102022-09-10 Journal: Nature Communications [Category] 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus Asymptomatic chemokines children clinical heterogeneity comprehensive analysis coronavirus coronavirus 2 disease dysregulated dysregulation Endothelial dysfunction heterogeneity hyperinflammation Hyperinflammatory identify IFN-γ IFN-γ response IFNγ IFNγ level IFNγ levels indicate Infection infection with SARS-CoV-2 Inflammation Inflammatory initial interferon gamma interferons Macrophage macrophage activation syndrome marker mediators Mild MIS-C overlap pathogenic Patient patients Pediatric patients phenotype PLA2G2A plasma Predictive markers Protein proteome respiratory response rheumatology SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 Symptoms syndrome thrombotic thrombotic microangiopathy Vascular Vascular injury viral infection Week [DOI] 10.1038/s41467-021-27544-6 PMC 바로가기 [Article Type] Article
Current situation of vaccine injury compensation program and a future perspective in light of COVID-19 and emerging viral diseasesResearch Article Published on 2021-12-072022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] abstracts adverse effect adverse effects Analysis approach article Asia bases caused comprehensive analysis concerning coronavirus disease country COVID-19 COVID-19 vaccines current death disease eligibility emerging viral diseases Europe highlight illnesses immunization include information Injury limitation New Perspective Program reducing mortality Research Result resulting rising searched selected South America The United States the vaccine vaccination Vaccine Vaccine Injury Compensation Programs vaccinee Vaccines viral disease [DOI] 10.12688/f1000research.51160.2 PMC 바로가기 [Article Type] Research Article
Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms경증에서 중등도의 증상을 보이는 COVID-19 환자의 차세대 혈장 프로테옴 프로파일링Clinical Trial Published on 2021-11-272022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, [키워드] Accuracy addition analyzed caused cellular mechanism cellular mechanisms comprehensive analysis COVID-19 COVID-19 patient COVID-19, Corona virus disease 2019 cytokine cytokine response death diagnosed disease Disease progression Effect elevated facilitate finding foundation functions funding host cell host cell receptor identify immune response individual Infection involved Knut Mild moderate moderate symptoms molecular molecular mechanism next generation sequencing Patient plasma plasma protein Plasma proteome platform profile Protein protein level protein levels Protein profiling proteome proximity extension assay sacrifice SARS-CoV-2 virus SCARB2 sensitivity Sequencing severe symptom severe symptoms shown significantly supported Symptom the disease the SARS-CoV-2 virus virus entry [DOI] 10.1016/j.ebiom.2021.103723 PMC 바로가기 [Article Type] Clinical Trial