Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning methodResearch article Published on 2022-10-012022-10-05 Journal: Applied Soft Computing [Category] 바이오마커, 변종, 신약개발, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis approach artificial intelligence assist available data Bioinformatics analysis biological pathway Biomarkers Comprehensive comprehensive analysis coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathology defined disease dominant effective Features first stage help host cell implementation introduced machine learning material Novel coronavirus pathway Pathway analysis Pathway enrichment analysis Pathways researcher SARS-CoV-2 selected Signaling target Treatment unsupervised learning WHO World Health Organization worldwide crisis [DOI] 10.1016/j.asoc.2022.109510 [Article Type] Research article
SARS-CoV-2 VOCs, Mutational diversity and clinical outcome: Are they modulating drug efficacy by altered binding strength?Research article Published on 2022-09-012022-10-05 Journal: Genomics [Category] SARS, 변종, [키워드] Analysis binding comprehensive analysis coronavirus COVID-19 pandemic Delta disease disease severity Drug efficacy Efficacy Genomic surveillance indicate less modulating molecular docking Mortality mutant Mutation mutation analysis NTD omicron outcome patients performed Protein RBD recovered recovered patients respiratory SARS-CoV-2 SARS-CoV-2 genome sequenced significantly spike syndrome T19R the patient the RBD variants of concern VoC VOCs [DOI] 10.1016/j.ygeno.2022.110466 [Article Type] Research article
Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variantsSARS-CoV-2 변이체의 세포 진입을 광범위하게 차단하기 위한 AAVrh10 벡터화 ACE2 기능 도메인의 합리적인 설계Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 ortholog ACE2 orthologs adeno-associated virus Adeno-associated virus (AAV) vector amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 breadth Candidates cell entry comprehensive analysis COVID-19 COVID-19 vaccine domain Effectiveness Ex vivo exhibited fragment of functional higher affinity human ACE2 in silico in vitro Infection Interaction neutralizing antibody Protein RBD Receptor binding domain sACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants serotype the RBD therapeutic strategy therapy These data tissue tropism variant variants virus was performed weakened [DOI] 10.1016/j.antiviral.2022.105383 PMC 바로가기 [Article Type] Article
Contrasting Distribution of SARS-CoV-2 Lineages across Multiple Rounds of Pandemic Waves in West Bengal, the Gateway of East and North-East States of IndiaArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome alteration Amino acid analyzed B.1.617.2 caused Characteristics comprehensive analysis coronavirus coronavirus disease country COVID19 Delta distribution East Epidemiology Evolution gateway genomic variation host miRNA hydrophobicity profile implication India Infection information Lineage miRNA molecular Multiple Mutation North nucleocapsid pandemic Predictive profile Region reveal SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 lineage sequencing data South state variant Viral protein Viral transmission viral variant virus genome Wave West West Bengal [DOI] 10.1128/spectrum.00914-22 PMC 바로가기
A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccinesArticle Published on 2022-08-262022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] addition asymptomatic infection BNT162b2 booster Breakthrough infection caused comprehensive analysis COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines COVID-19-related death cumulative Delta delta variant effective Effectiveness Efficacy ENhance heterogenous homologous immunization incidence Infection interval less mRNA-1273 omicron Prevent PROTECT SARS-CoV-2 SARS-COV-2 infection severe COVID-19 symptomatic the SARS-CoV-2 vaccination Vaccine variant variants [DOI] 10.3389/fimmu.2022.945930 PMC 바로가기
SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemicReview Published on 2022-08-182022-10-05 Journal: Immunity [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome analyzed anatomical cellular immunity Combination comprehensive analysis coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 vaccines defined disease epidemiological evade Evidence Host humoral Humoral immunity Hybrid immunity immundominance Immunity Infection magnitude modify neutralizing antibody pandemic PROTECT SARS-CoV-2 SARS-CoV-2-specific T cell severe COVID-19 Support T cell tissue-resident T cells vaccination variable variant Virological [DOI] 10.1016/j.immuni.2022.08.008 [Article Type] Review
Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine doseBNT162b2 2회 접종 후 노인 인구에서 백신 획득 면역 저하 세 번째 백신 접종으로 완화Article Published on 2022-08-082022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] acquired immunity age Analysis antibody Antibody Response BNT162b2 boost cellular response Cellular responses comprehensive analysis Delta develop dose identify immune response Immunity individual individuals induce less Lower memory memory immune response mRNA vaccine Older omicron Protein Responder responses SARS-CoV-2 Spike protein sustained T cell T cell response the Spike understanding vaccination Vaccinations Vaccine vaccine dose Vaccine-induced immunity vaccinee vaccinees variant variants Wuhan strain [DOI] 10.1038/s41467-022-32312-1 PMC 바로가기 [Article Type] Article
In Silico Analysis of the Effects of Omicron Spike Amino Acid Changes on the Interactions with Human Proteins인간 단백질과의 상호 작용에 대한 오미크론 스파이크 아미노산 변화의 효과에 대한 실리코 분석Article Published on 2022-07-282022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 3D structure acid adopted affected Amino acid amino acid change amino acid changes among others Analysis antibodies antibody applied approach can be used change characterized complexes comprehensive analysis detectability Effect Epidemiology Human Interaction Mutation omicron other variants predict predicted Protein protein variants protein–protein interactions resolved SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant selected spike spike glycoprotein Spike protein Transmissibility [DOI] 10.3390/molecules27154827 PMC 바로가기 [Article Type] Article
Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen공분산은 인간 병원체로서 SARS-CoV-2의 출현과 지속적인 진화에 중요한 보존된 단백질 잔기 상호작용을 예측합니다Article Published on 2022-07-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] allele alleles Amino acid amino acid residue amino acid residues Analysis approach caused change Combination comprehensive analysis conserved coronavirus CoV CoV genome covariance CoVs difference dominant Epidemics Evolution Evolution of SARS-CoV-2 exhibited followed by Frequency Genome host adaptation human pathogen implicated incrementally independent Interaction Lineage lineages nucleotide occurred Pandemics Pathogens predict Protein protein sequence Region reservoirs residue SARS-CoV-2 SARS-CoV-2 variants statistically unique Viral protein Viral proteins β-coronavirus β-Coronaviruses [DOI] 10.1371/journal.pone.0270276 PMC 바로가기 [Article Type] Article
Impact of the COVID-19 pandemic on the mental health of hospital staff: An umbrella review of 44 meta-analysesCovid-19 Pandemic이 병원 직원의 정신 건강에 미치는 영향 : 44 메타 분석의 우산 검토Review Published on 2022-07-012022-08-31 Journal: International journal of nursing studies [Category] MERS, meta-analysis, [키워드] 95% CI Acute stress affected Analysis analyzed Anxiety applied article CINAHL comprehensive analysis conducted coronavirus COVID-19 COVID-19 pandemic dataset Depression disorders Doctors Egger test Evidence examined female Final final analysis GRADE Health care health problems heterogeneity high risk highest hospital Hospital staff Impact Insomnia lack life male medical staff mental health mental health issue mental health issues mental health problem mental health problems meta-analyses Meta-analysis Nurse Nurses observational studies observational study outcome pandemic poor quality post-traumatic Prevalence PRISMA problem PsycINFO Publication bia publication bias random effect reduced Registered reported representing review robust sleep disorder sleep disorders Stata study heterogeneity suffered Support Symptom Symptomatology Symptoms systematic review systematic reviews was used [DOI] 10.1016/j.ijnurstu.2022.104272 PMC 바로가기 [Article Type] Review