conformations

[키워드] activity addition Amiloride amilorides antiviral activity antiviral potency Author binding binding affinity binding site biochemical budding C-terminal causative agent change channel inhibitors characterized chemical shift Complete complex conformation conformations contribute correlated COVID-19 COVID-19 treatment cytoplasmic domain Drug discovery E protein envelope exhibit form foundation full-length SARS-CoV-2 group Guidance Health hexadecylphosphocholine hydrophobic information inhibitor inhibitors Interaction interactions ion channel lack linker membrane protein molecular Mutation N-terminal NMR spectroscopy Novel coronavirus novel coronavirus SARS-CoV-2 pandemic pandemic of COVID-19 Pathogenesis Perturbation Protein Protein conformation pyrazine rapid progress residue residues respiratory respiratory infection responsible SARS-CoV-2 SARS-CoV-2 envelope structural protein structural proteins Structure threat transmembrane transmembrane domain Treatment truncation Vaccines Vero E6 VERO E6 cells Viral viral genome Viral proteins viral replication virion assembly virus-like particles while
[DOI] 10.1371/journal.ppat.1009519 PMC 바로가기 [Article Type] Research Article