Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19SARS-COV-2 유도 된 작은 RNA의 검출 및 COVID-19와 관련된 순환 소형 RNA의 변화Brief Report Published on 2021-08-112022-09-10 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] Ageusia Analysis candidate gene change circulating circulating-miRNA cleavage conserved convalescent COVID-19 patient COVID COVID-19 cytokine Cytokine storm Defense defense mechanism described detectable detection double-stranded RNA events homologous Host host defense human miRNA human miRNAs immune response immune responses Jak-STAT Long COVID mechanism Mild miRNA miRNAs NSP2 nsp4 plasma plasma sample plasma samples product reduced RNA sequence RNAs SARS-CoV-2 sequence Sequencing severe cases severe COVID-19 siRNA small RNA Small RNAs STAT Symptoms the disease transcriptional gene silencing Trigger triggers Viral viral infection virus with COVID-19 [DOI] 10.3390/v13081593 PMC 바로가기 [Article Type] Brief Report
Persistent Endothelial Dysfunction in Post-Acute COVID-19 Syndrome: A Case-Control StudyArticle Published on 2021-08-042022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] age alteration arterial oxygen tension Biomarkers cardiovascular risk factors case-control study clinical variables complications confounders Control convalescent COVID-19 patient convalescent COVID-19 patients coronavirus disease correlated correlation COVID-19 COVID-19 patient diffusing disability dysfunction Endothelial dysfunction endothelial function evaluated exercise exhibited expiratory female for inclusion Gender independent male males no significant difference outcomes Pathogenesis persistent pulmonary pulmonary impairment rehabilitation severity significantly higher significantly lower study population subgroup analysis Swab test syndrome unit Volume [DOI] 10.3390/biomedicines9080957 PMC 바로가기 [Article Type] Article
Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike proteinResearch article Published on 2021-08-012022-10-05 Journal: Vaccine: X [Category] 치료제, [키워드] Anti-viral anti-viral antibody antibody Antibody Response antigen-specific T cell Antiviral approach auxiliary B cell repertoire Cell characterized components convalescent COVID-19 patient convalescent patient convalescent plasma COVID-19 COVID-19 convalescent patient COVID-19 patient demonstrated effective expected full-length full-length protein humoral identify Immunoglobulin majority membrane memory B memory B cell monoclonal antibody nucleocapsid ORF performed produced Protein Proteins Pseudovirus neutralization assay RBD reveal S protein SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection Somatic hypermutation specific antibody spike the antibody the receptor-binding domain the Spike the spike protein Viral proteins [DOI] 10.1016/j.jvacx.2021.100098 [Article Type] Research article
Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemicsArticle Published on 2021-07-272022-10-04 Journal: Scientific Reports [Category] 변종, 임상, 진단, [키워드] aAPC activated Antigen antigen presenting cell Applied immunology approach Biotechnology catalytic Cell Clinical course clinical investigation clinically co-stimulatory molecule complexes contribute convalescent COVID-19 patient COVID-19 COVID-19 infection cytokine profile cytomegalovirus Donor effector memory evaluate expand explain generate histocompatibility complex immune immune response immunodominant immunology induced infiltrating leukocyte lymphocyte MHC Mild mononuclear cell Mortality Multisystem organ failure Pandemics Patient PBMC Peripheral blood phenotype Pragmatic prognosis of patient protocol rapid expansion REP robust SARS-CoV-2 SARS-CoV-2 viral T cell T cell receptor therapeutic therapeutic option therapy therapy for COVID-19 Treatment viral pathogen virus [DOI] 10.1038/s41598-021-94654-y PMC 바로가기 [Article Type] Article
Longitudinal trajectories of pneumonia lesions and lymphocyte counts associated with disease severity among convalescent COVID-19 patients: a group-based multi-trajectory analysisResearch Published on 2021-07-132022-10-28 Journal: BMC Pulmonary Medicine [Category] COVID-19, [키워드] Analysis applied association Characteristics Clinical course Cohort convalescent convalescent COVID-19 patient Course COVID-19 COVID-19 patient declined diabete disease severity dropped females Follow-up group Group-based multi-trajectory modelling groups heterogeneous hypertension identify IMPROVE IQR longitudinal lymphocyte Lymphocyte count male much higher Older Patient Pneumonia pneumonia lesion reached restored Result risk severe disease subgroups supplementary material Trajectories trajectory Volume [DOI] 10.1186/s12890-021-01592-6 PMC 바로가기 [Article Type] Research
Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19COVID-19에 걸린 회복기 환자에서 유도된 항체에 의한 중화에 대한 SARS-CoV-2 변이체의 내성Article Published on 2021-07-132022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike anti-spike antibody anti-spike MAbs antibody antibody-based therapies antibody-based therapy B.1.1.7 B.1.351 Brazil caused Cluster convalescent COVID-19 patient convalescent patient Convalescent patients convalescent plasma convalescent plasma samples coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 effective Efficacy evaluate FIVE high affinity IgG Immunoglobulin Impact Infection mAb mAbs memory B cells Mutation neutralization Neutralizing neutralizing activities Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody P.1 patients Rapid Receptor-binding domain resistance respiratory robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly single-cell South Africa Spike protein Spread the receptor-binding domain the spike protein therapeutic option Vaccine variant variants with COVID-19 [DOI] 10.1016/j.celrep.2021.109385 PMC 바로가기 [Article Type] Article
A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients림프구 적응 면역 레퍼토리 및 전사체의 단일 세포 아틀라스는 회복기 COVID-19 환자의 연령 관련 차이를 보여줍니다Comparative Study Published on 2021-07-122022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation adaptive Adaptive immune response Adaptive immunity age Analysis antibody Atla B cell B cell receptor B cell receptors B cells B lymphocytes BCR CD4 CD8 Cell cell receptor clearance clone convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 COVID-19 disease COVID-19 patient Critical cytotoxicity dependent on difference effector elderly patients elevated GNLY groups GzmA GZMH IgA immune Immunity implicated knowledge lymphocyte Lymphocytes marker outcome Patient patients plasma Plasma cell PRF1 receptor repertoire SARS-CoV-2 Sequencing single-cell T and B cells T and B lymphocytes T cell TCRs Transcriptome transcriptomes transition VDJ repertoire [DOI] 10.3389/fimmu.2021.701085 PMC 바로가기 [Article Type] Comparative Study
Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody SerologySARS-CoV-2 항체 혈청 검사가 음성인 회복기 COVID-19 환자의 반응성 T 세포Immunology Published on 2021-07-122022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, 치료법, [키워드] analyzed Antibody Response CD4+ T cell convalescent convalescent COVID-19 patient convalescent individuals convalescent patient Convalescent patients coronavirus Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patients cytokine detectable disease course elicited Endemic flow cytometry Frequency HCoV HCoV-229E healthy control healthy controls human endemic coronavirus 229E (HCoV-229E) human endemic coronavirus OC43 (HCoV-OC43) IFN IL-2 Mild negative nucleocapsid peptide peptide pool persistence positive question raise reactive RT-PCR SARS-CoV-2 SARS-CoV-2 spike seronegative seropositive serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific antibodies specific antibody Stimulation T cell T cell response T cells TNFα undetectable Viral viral control [DOI] 10.3389/fimmu.2021.687449 PMC 바로가기 [Article Type] Immunology
A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutationsResearch article Published on 2021-07-072022-10-05 Journal: Cell Reports [Category] SARS, 변종, [키워드] ACE2 ACE2-RBD anti-SARS-CoV-2 antibodies antibody antibody fragment bind binding blocked cause clinical trial complex convalescent COVID-19 patient coronavirus coronavirus disease COVID-19 COVID-19 patient demonstrated develop disease Efficacy Fab hACE2 human Angiotensin-converting enzyme human IgG1 IC50 immune library in vivo in vivo neutralization live SARS-CoV-2 mice moderate Neutralization assay Neutralizing neutralizing antibody novel Betacoronavirus phage display phase RBD RBD mutation RBD mutations recombinant antibody SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variants SARS-CoV-2-RBD scFv selected severe COVID-19 severe pneumonia Spike protein the receptor-binding domain the spike protein Treatment [DOI] 10.1016/j.celrep.2021.109433 [Article Type] Research article
Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in WuhanArticle Published on 2021-07-062022-10-04 Journal: Nature Communications [Category] SARS, 임상, 치료기술, 치료법, [키워드] acute respiratory syndrome Adaptive immunity age antibodies antibody Antibody Response Antibody titer Antimicrobial responses convalescent convalescent COVID-19 patient convalescent plasma coronavirus coronavirus disease COVID-19 COVID-19 pandemic decrease Diagnosis domain Donor exceeded facilitate female Health humoral immune response IgG antibody IgG response immune memory Immunity initial male Neutralizing antibody titer older patient patients plasma plasma sample positive correlation positive rate promote reduce responses risk SARS-CoV-2 Spike protein the patient therapy Vaccine viral infection Wuhan Wuhan, China [DOI] 10.1038/s41467-021-24230-5 PMC 바로가기 [Article Type] Article