Long-Term Kinetics of SARS-CoV-2 Antibodies and Impact of Inactivated Vaccine on SARS-CoV-2 Antibodies Based on a COVID-19 Patients CohortCOVID-19 환자 코호트를 기반으로 한 SARS-CoV-2 항체의 장기 동역학 및 비활성화된 백신이 SARS-CoV-2 항체에 미치는 영향Immunology Published on 2022-01-272022-09-12 Journal: Frontiers in Immunology [Category] 진단, [키워드] antibody Antibody responses antibody titres blood sample boost Characteristics chemiluminescence China Cohort collected convalescent patient Convalescent patients COVID-19 demographics dose enrolled enzyme epidemiological data follow-up time IgG IgG antibody IgG level IgM immunoassay Impact Inactivated vaccine individuals information IQR Jiangsu kinetic Kinetics long-term kinetics majority median natural infection Neutralizing antibodies neutralizing antibody participant Patient populations positive remained Result RT-PCR SARS-CoV-2 SARS-CoV-2 antibody significantly higher single dose symptom onset tested understanding vaccinated individual vaccination Vaccination strategy [DOI] 10.3389/fimmu.2022.829665 PMC 바로가기 [Article Type] Immunology
T-Cell Repertoire Characteristics of Asymptomatic and Re-Detectable Positive COVID-19 Patients무증상 및 재검출 가능한 COVID-19 양성 환자의 T-세포 레퍼토리 특성Immunology Published on 2022-01-272022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 치료기술, [키워드] analyzed Asymptomatic asymptomatic patient asymptomatic patients Combination convalescent Convalescent patients courses COVID-19 COVID-19 pandemic COVID-19 patient help immune repertoire sequencing immune response immune responses immunological Immunotherapy positive predict Prevalence re-detectable positive case recurrent infection repertoire risk Surveillance symptomatic T-cell receptor TCR [DOI] 10.3389/fimmu.2021.769442 PMC 바로가기 [Article Type] Immunology
A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies발견 플랫폼의 전염병 지원 비교는 순진한 항체 라이브러리가 최고의 면역 출처 항체와 일치할 수 있음을 보여줍니다Comparative Study Published on 2022-01-242022-09-12 Journal: Nature Communications [Category] 신약개발, 진단, [키워드] affinities antibodies antibody Antibody generation Antigen Applied immunology comparable convalescent patient Convalescent patients downstream Efficacy generate group hyperimmune immune immunization immunized less naïve neutralization activities neutralization activity Neutralizing antibodies neutralizing antibody non-immune pandemic platform provided SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike protein significantly Specificities specificity Spike protein the antibody the SARS-CoV-2 therapeutic therapeutic antibodies unique viral infection viral pathogen yielding [DOI] 10.1038/s41467-021-27799-z PMC 바로가기 [Article Type] Comparative Study
Development of a quantitative COVID-19 multiplex assay and its use for serological surveillance in a low SARS-CoV-2 incidence community정량적 코비드 -19 멀티 플렉스 분석의 개발 및 낮은 SARS-COV-2 발병 커뮤니티에서 혈청 감시에 대한 사용Research Article Published on 2022-01-212022-09-10 Journal: PLoS ONE [Category] 진단, 치료기술, 치료법, [키워드] anti-RBD antigens AUC can be used Cohort collected Community controls convalescent patient Convalescent patients correlated correlation COVID-19 COVID-19 PCR test detection development domain dynamic range evaluated Exposure Rate expressed expression greater healthy volunteer healthy volunteers identify IgA IgG IgM immune response incidence incidence rate Infection initial Ithaca mammalian moderate Multiplex assay Neutralization assay nucleocapsid protein pandemic Patient PCR test performed positive result Quantitative quantitative assay RBD RBD antigen RBD protein RBD proteins Receptor-binding domain Sample SARS-CoV-2 SARS-CoV-2 virus selected serological serological surveillance Serological testing Seroprevalence serum serum sample serum samples Spike protein the SARS-CoV-2 the spike protein vaccination Volunteer [DOI] 10.1371/journal.pone.0262868 PMC 바로가기 [Article Type] Research Article
Regional and temporal coordinated mutation patterns in SARS-CoV-2 spike protein revealed by a clustering and network analysis클러스터링 및 네트워크 분석에 의해 밝혀진 SARS-COV-2 스파이크 단백질의 지역 및 시간적 조정 돌연변이 패턴Article Published on 2022-01-212022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 치료기술, [키워드] antibody applied automated circulating Cluster Clustering Computational biology and bioinformatics Convalescent patients correlated country detect Evolution Frequency GISAID database group higher infectivity immunology low frequency mutated Mutation mutations network analysis neutralization occur Regional regions SARS-CoV-2 SARS-CoV-2 spike protein sequence sera Spike protein Spread strain Strains the SARS-CoV-2 Treatment vaccinated individual vaccinated individuals Vaccine design variant variants VoC VOCs while WHO [DOI] 10.1038/s41598-022-04950-4 PMC 바로가기 [Article Type] Article
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infectionSARS-COV-2 감염 후 몇 달 후 말초 면역계의 장기 섭동Research Article Published on 2022-01-142022-09-01 Journal: BMC Medicine [Category] SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Analysis anti-RBD Anti-RBD IgG Antibody responses Blood cellular controls convalescent convalescent individual convalescent individuals Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID COVID-19 Critical CXCR3 deep disease severity Effects explain follicular Gene Expression healthy healthy controls IgG responses immune population immune response immune responses immune system Immunity Immunophenotyping in some increasingly individuals Infection Long COVID Mild moderate molecular Monocytes Neutrophils NK cells pandemic PASC Patient persistence Perturbation plethora Post COVID-19 condition Post-acute sequelae of COVID-19 (PASC) Post-infection referred to regulatory T cells reported Research respiratory respiratory virus response responsible Result RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significant differences supplementary material Symptom syndrome T cell T cells T helper transcriptional transcriptional level Transcriptome uninfected [DOI] 10.1186/s12916-021-02228-6 PMC 바로가기 [Article Type] Research Article
Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors공공 및 민간 T 세포 수용체가 인식하는 HLA-A2 제한 SARS-CoV-2 스파이크 에피토프의 구조적 평가Article Published on 2022-01-102022-09-10 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] antibody B-cell cellular immunity complex conserved Convalescent patients COVID-19 convalescent patient Critical determine effort elicit epitope Epitopes germline gene homologous epitope homologous epitopes immune response Immunity immunodominant immunology infective agent information less long-term memory mechanism Memory responses Neutralizing antibodies neutralizing antibody receptors Recognition recognize SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein seasonal coronaviruses Spike protein Structure structures T cell T cell receptors T cells T-cell receptor T-Cell Receptors target targeted epitope TCR TCRs Vaccine variant X-ray crystallography [DOI] 10.1038/s41467-021-27669-8 PMC 바로가기 [Article Type] Article
Surveillance of SARS-CoV-2 antibodies of patients in the local affected area during Wuhan lockdownWuhan Lockdown 동안 국소 영향을받는 지역에서 환자의 SARS-COV-2 항체 감시Research Article Published on 2022-01-042022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, 치료기술, 치료법, [키워드] affected age All participants clinic Clinical sign Clinical signs Comorbidity convalescent patient Convalescent patients COVID-19 COVID-19 outbreak COVID-19 pandemic fragment of gold herd immunity highest Humoral immunity IgG IgM IgM and IgG Immunity indicated individual individuals information Local lockdown medical staff men natural reservoir no significant difference nucleic acid nucleocapsid outbreak Outpatient participant Patient positive rate positive rates Prevalence prevalence rate provide qualitative test Result SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgM SARS-CoV-2 infections sensitivity Seroprevalence Serosurveillance significant difference significantly higher specificity Spike protein syndrome the mean the SARS-CoV-2 Vaccination strategy Vaccine virus was measured were measured women Wuhan [DOI] 10.1186/s12879-021-07010-w PMC 바로가기 [Article Type] Research Article
Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2SARS-COV-2에 대한 항 -RBD 인간 단일 클론 항체의 구조 및 치료 가능성Research Paper Published on 2022-01-012022-09-01 Journal: Theranostics [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] In vitro and in vivo function abrogated ACE2 Analysis anti-RBD Anti-RBD antibody anti-receptor-binding domain antibodies antibody antibody cocktail Antibody-antigen complex attenuate B.1.1.7 B.1.351 B.1.617.2 binding cocktail convalescent patient Convalescent patients COVID-19 Cryo-electron microscopy Crystallography curtail dissect effective Efficacy electron microscopy epitope Epitopes evaluate feature Formulation hamster hamsters Hospitalization Human monoclonal antibody in vitro in vivo Infection leads lung viral load mechanism mechanism of action monoclonal antibodies monoclonal antibody Mutation neutralization Neutralizing neutralizing monoclonal antibodies non-overlapping epitope non-overlapping epitopes patients with SARS-CoV-2 Prevent Prophylactic pulmonary inflammation RBD Receptor-binding domain epitope reduce reported residue reveal SARS-CoV-2 SARS-COV-2 infection shown somatic mutations Structural analysis Structure structure-function subsequent Support the RBD therapeutic therapeutic potential unique variable region variant variants variants of concern Viral viral RBD viral shedding virus weight loss wild type [DOI] 10.7150/thno.65563 PMC 바로가기 [Article Type] Research Paper
The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron유사형 SARS-CoV-2 변이체 오미크론의 유의미한 면역 탈출Coronaviruses Published on 2021-12-212022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Alpha BA.1 Beta convalescence serum Convalescent patients COVID-19 convalescent patient COVID-19 infection COVID-19 vaccines D614G Delta ED50 elicited finding Gamma Immune escape immune protection in vitro indicated infected with SARS-CoV-2 Lambda lead Mutation neutralization neutralization activity omicron Omicron variant other variant other variants Protein pseudotyped pseudotyped SARS-CoV-2 Pseudotyped virus reference strain SARS-CoV-2 SARS-COV-2 infection sensitivity sera serum sample serum samples Spike protein susceptibility the mean the Spike Vaccine variant variants variants of interest viruses VoC VOCs VOIs was tested [DOI] 10.1080/22221751.2021.2017757 PMC 바로가기 [Article Type] Coronaviruses