Female reproductive tract has low concentration of SARS-CoV2 receptors여성 생식기는 SARS-CoV2 수용체 농도가 낮습니다.Research Article Published on 2020-12-142022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] ACE2 Breast cathepsin cathepsin B cathepsin L cell type cell types co-expression Concentration Cornea CTSB CTSL dataset detect explain expression facilitate fallopian tube female reproductive organ female reproductive organs host cell Infection investigated myometrium nasal epithelium outcome pandemic Prevalence Proteases recent receptor receptors reproductive reproductive organs SARS-CoV2 SARS2 Sequencing single-cell susceptible the cell tissue TMPRSS2 Transmission unlikely uterus [DOI] 10.1371/journal.pone.0243959 PMC 바로가기 [Article Type] Research Article
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer범암에서 CTSL/B 및 SARS-CoV-2 수용체 ACE2의 게놈, 후성유전체 및 면역 아형 분석Research Paper Published on 2020-11-302022-09-10 Journal: Aging (Albany NY) [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE2 addition Analysis analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 association bioinformatics Cancer cathepsin cathepsin B cathepsin L Cell Cervical copy number COVID-19 CTSB CTSL CTSL/B Cystadenocarcinoma demonstrated DNA methylation endocervical enzyme epigenomic Gene Expression genetic alterations healthcare IFN-gamma immune International Methylation negative correlation ovarian overexpressed positive correlation potential risk present Prognosis protease receptor Result risk risk factor RNA expression SARS-coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor serous Cystadenocarcinoma Society Squamous cell Squamous cell carcinoma stomach subtype upregulation urothelial carcinoma [DOI] 10.18632/aging.104147 PMC 바로가기 [Article Type] Research Paper
Impact of Comorbidities on SARS-CoV-2 Viral Entry-Related GenesArticle Published on 2020-09-252022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 bradykinin Cancer cardiovascular disease cathepsin cell type Comorbidities Comorbidity condition contribute coronavirus COVID-19 CTSL demonstrated diabete disease distribution downstream elevated Entry mechanism Express expression expression level furin Genes healthy individuals heparan sulfate proteoglycans host cell hypertension Impact IMPROVE in healthy individual increased expression individual isoform lysosomal mechanism membrane membrane-bound modulated organ organ system organ systems other TTSP outcome outcomes Patient populations prevalent proteoglycans receptors renin-angiotensin aldosterone system representing SARS-CoV-2 smoking therapeutic target tissues TMPRSS2 transmembrane serine protease transmembrane serine proteases tropism TTSPs virulence [DOI] 10.3390/jpm10040146 PMC 바로가기 [Article Type] Article
Potential of Ocular Transmission of SARS-CoV-2: A ReviewReview Published on 2020-09-012022-10-29 Journal: Vision [Category] COVID-19, [키워드] ACE2 addition analyzed carried cathepsin CD147 Cell conjunctivitis coronavirus COVID-19 CTSL datasets Evidence gene expression profile immunohistochemistry implication infect infect cell infected with SARS-CoV-2 Infection likelihood mechanism molecular mechanism nasal nasal epithelium ocular Ocular surface ocular transmission Potential Proteins recent replicates Retina review SARS-CoV-2 TMPRSS2 Transmission virus [DOI] 10.3390/vision4030040 PMC 바로가기 [Article Type] Review
Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Potential implications beyond loss of smell as a COVID‑19 symptomSARS-CoV-2 감염 매개체와 말초 후각 수용체의 동시 발현: COVID-19 증상으로서 후각 상실 이상의 잠재적 의미Article Published on 2020-09-012022-09-11 Journal: International journal of molecular medicine [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome adipose Adipose tissue analysed angiotensin Anosmia atlas bladder Brain cathepsin L caused Cell cellular protease Clinical studies clinical study COVID‐19 CTSL damage disease enzyme expressed expression expression profile facilitated function GeneMANIA healthy heart highlight host cells host cells) human host cell human host cells Hyposmia implication in vitro Infection interact kidney liver Local Loss of Smell mechanism mediators nasal New olfactory olfactory bulb olfactory receptor OR51E2 pancrea pancreas periphery plethora Potential Profiling Prostate protease receptor required respiratory Serine serine 2 Severe acute respiratory syndrome significantly Symptom Testis Thyroid tissue tissues TMPRSS2 transmembrane transmembrane protease serine 2 upregulated [DOI] 10.3892/ijmm.2020.4646 PMC 바로가기 [Article Type] Article
Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2Cell and Developmental Biology Published on 2020-08-192022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] abundantly expressed ACE2 addition ANPEP binding carried Cell cells cellular co-expressed Complication component coronavirus Coronaviruses COVID-19 CTSB CTSL DPP4 during pregnancy Express expressed Factor Glucose healthy host cells Human identify in viral infected with SARS-CoV-2 Infection Inflammation involved JAK-STAT pathway marker membranes mitochondrial metabolism mother mRNA Neonate novel coronavirus disease Other other protease pathogen pathway physically Placenta placental positive predict Pregnancy pregnant women Premature priming proportion protease TMPRSS2 Proteases PROTECT Protein receptor receptor ACE2 receptors Replication required respiratory RNA-Seq rupture SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection shown single-cell RNA-seq subset subtype systematic review target the S protein these cell TMPRSS2 Transport trophoblast unique viral S protein Viremia virus were also expressed with COVID-19 [DOI] 10.3389/fcell.2020.00783 PMC 바로가기 [Article Type] Cell and Developmental Biology