In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age
바이러스 부하, 성별 및 연령에 따른 SARS-CoV-2에 대한 생체 내 항바이러스 숙주 전사 반응
Research Article
[키워드] ACE2
Activation
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
age
age and sex
Antiviral
antiviral response
antiviral responses
CD8A
cells
chemokine
chemokines
chemokines CXCL9
clinical manifestation
clinical manifestations
contribute
coronavirus
Course
Culture
cultures
CXCL9
CXCR3
Cytotoxic T cell
Cytotoxic T cells
days post infection
deficiencies
deficiency
demonstrated
dependent on
disease severity
elapsed
elevated
examined
expression
Factor
females
Gene Expression
Genes
genomic
granzyme B
HAE
Host
host response
host responses
Host transcriptional response
human airway epithelial
humoral immune responses
IFIT1
immune responses
in vivo
increase in
individual
induce
Infection
Inflammation
inhibitor
inhibitors
interferon
interferon signaling
interferon-stimulated gene
interferon-stimulated genes
male
mechanism
nasopharyngeal
natural killer
negative controls
neutrophil
NF-κB
nuclear
OAS1
Patient
PCR-confirmed
populations
profile
Protein
Proteins
receptor
reduced
reduction in
relative
replicated
respiratory
reveal
RNA sequencing
SARS-CoV-2
SARS-COV-2 infection
severe acute respiratory syndrome Coronavirus
Sex
shotgun
shown
Signaling
specimen
Swab
T cells
T helper
Th1
transcript
Transcription
transcripts
up-regulation
Viral
Viral load
wound healing
[DOI] 10.1371/journal.pbio.3000849 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pbio.3000849 PMC 바로가기 [Article Type] Research Article