Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition
인간 심근세포의 고효율 SARS-CoV-2 감염: 스파이크 단백질 매개 세포 융합 및 억제
Virus-Cell Interactions
[키워드] 2019
aberrant host response
accounted
ACE2
Activation
activity
Acute respiratory infection
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
Amino acid
angiotensin
Angiotensin-converting enzyme
angiotensin-converting enzyme 2
Autopsy
block
canonical
cardiac
cardiac complication
Cardiac complications
cardiac damage
cardiac tropism
cardiovascular complication
cardiovascular complications
catalytic site
Cell
Cell fusion
cell lines
cell surface
cell-cell fusion
cells
cleavage
cleavage site
coding
coronavirus
coronavirus disease
correlated
COVID-19
COVID-19 patient
cytopathic
Cytopathic effect
cytoplasm
cytoplasmic tail
direct infection
disrupt
Drug discovery
efficient
examined
exceeded
Express
expressed
expression vector
fluorescent
furin
furin cleavage motif
furin-like protease
furin-like proteases
fused
fusing
fusion
fusion inhibition
green fluorescent protein
Human
human cardiomyocyte
in vitro model
inactive
Infection
inhibition
Lungs
mechanism
monomeric
mRNA
mutant
Mutation
Myocardium
occur
other coronavirus
other coronaviruses
parental
Particle
patients
peptide-based
platform
pluripotent stem cell-derived cardiomyocytes
protease
Protein
protein cleavage
Proteolytic processing
receptor
replicate
required
respiratory
respiratory infection
SARS-CoV-2
SARS-COV-2 infection
Serine
serine 2
severe acute respiratory syndrome Coronavirus
spike
Spike protein
Spread
structures
Syncytia
systemic inflammation
the spike protein
These data
thrombosis
tissue
TMPRSS2
Transformed cell
transmembrane
transmembrane protease serine 2
tropism of SARS-CoV-2
Vesicle
Viral
viral replication
viral transcript
viral transcription
viral transcripts
Virus-like particle
virus-like particles
viruses
[DOI] 10.1128/JVI.01368-21 PMC 바로가기 [Article Type] Virus-Cell Interactions
[DOI] 10.1128/JVI.01368-21 PMC 바로가기 [Article Type] Virus-Cell Interactions