SARS-CoV-2 genome variations and evolution patterns in Egypt: a multi-center study이집트의 SARS-CoV-2 게놈 변이와 진화 패턴: 다기관 연구Multicenter Study Published on 2022-08-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료법, [키워드] addition China circulating variants city clade clades Clinical severity collected contribute correlation D614G diagnosed disappearance disease severity Evolution followed by Genetic GISAID global public health highly pathogenic Mild Mutation mutations next generation sequencing Nextstrain nucleocapsid ORF3a ORF8 pandemic Patient Phylogenetic Phylogenetic analysis positive COVID-19 Prevalence sample collection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 pandemic sequenced sequenced sample Sequencing Spike protein Spread the SARS-CoV-2 variant Variation Viral viral genome viral genomes Viral transmission virus Virus evolution was performed Wuhan [DOI] 10.1038/s41598-022-18644-4 PMC 바로가기 [Article Type] Multicenter Study
Nanomechanical analysis of SARS-CoV-2 variants and predictions of infectiousness and lethalityArticle Published on 2022-08-102022-11-16 Journal: Soft matter [Category] SARS, 변종, [키워드] Alpha variant Analysis approach B.1.351 B.1.617.2 Beta cause circulation COVID-19 D614G D614G mutation delta variant Effect epidemiological estimate explain higher infectivity interactions less Lineage Lineage B.1.1.7 molecular mutate Mutation offer pathogen pathway predict predicted Predictive Prevalence SARS-CoV-2 variant spike mutation Spike protein Spread strain variant variants virus virus spike protein viruses [DOI] 10.1039/d1sm01181b PMC 바로가기
Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings다양한 임상 환경에서 면역 저하 환자의 오미크론 변이체에 대한 동형 및 이형 면역 반응Article Published on 2022-08-042022-09-11 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] CD4 CD8 Cellular immune response clinical setting comparable controls cross-neutralization D614G Delta Delta variants disease severity dose Host humoral identify immune immune response immune responses Immunocompromised Immunocompromised patient Immunocompromised patients implication Infection magnitude neutralization neutralizing antibody omicron Organ transplant Patient patients peptide peptide pools Pseudovirus neutralization assay Re-infection recipient response responses risk of infection SARS-CoV-2 severe COVID-19 subset T-cell Response T-cell responses uninfected Vaccine variant variants [DOI] 10.1038/s41467-022-32235-x PMC 바로가기 [Article Type] Article
Evolutionary dynamics of SARS-CoV-2 circulating in Yogyakarta and Central Java, Indonesia: sequence analysis covering furin cleavage site (FCS) region of the spike protein족자카르타와 인도네시아 중부 자바에서 순환하는 SARS-CoV-2의 진화 역학: 스파이크 단백질의 푸린 절단 부위(FCS) 영역을 포괄하는 서열 분석Article Published on 2022-08-012022-09-11 Journal: International microbiology : the official journal [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis cDNA cDNA synthesis circulating clade Cluster Clusters confirmed COVID-19 patients coronavirus COVID-19 pandemic COVID-19 patient D614 variant D614G D614G mutation evolutionary dynamics FCS FIVE furin furin cleavage furin cleavage site G614 variant Genome GISAID indicated Indonesia Mutation Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples new SARS-CoV-2 new virus PCR amplification Protein Q677H Region replaced responsible retrieved RNA SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates sequence Sequence analysis Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 silent spike Spike protein synthesis the spike protein were used [DOI] 10.1007/s10123-022-00239-8 PMC 바로가기 [Article Type] Article
Insight into molecular characteristics of SARS-CoV-2 spike protein following D614G point mutation, a molecular dynamics studyD614G 점 돌연변이에 따른 SARS-CoV-2 스파이크 단백질의 분자 특성에 대한 통찰력, 분자 역학 연구Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] addition Amino acid amino acid sequence asymmetric bioinformatics catastrophic changes in Characteristics D614G D614G mutation Effect effective high mortality rate insight molecular molecular dynamics mutant Mutation negative charge Point mutation polar positive Positive Charge Protein public health Receptor binding residue risk factor SARS-CoV-2 SARS-CoV-2 spike protein secondary structure sequence spike stability Substitution tertiary structure the SARS-CoV-2 Treatment virus [DOI] 10.1080/07391102.2021.1872418 PMC 바로가기 [Article Type] Article
A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse seraVFLIP-X 스파이크를 생성하는 원형 mRNA 백신 프로토타입은 마우스 혈청에 의한 SARS-CoV-2 변이체의 광범위한 중화를 제공합니다Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Amino acid amino acid sequence amino acids Antibody titers B.1.1.529 B.1.617.2 balance BNT162b2 boost cellular immune responses cleavage site COVID-19 vaccine Critical D614G detectable Disulfide disulfide bond E484K Evolution of SARS-CoV-2 FIVE flexible glycosylation greater humoral Humoral and cellular immune responses immune responses immunization immunized induce K417N L452R linear linker mice mRNA mRNA vaccine mRNA vaccines mRNA-1273 N501Y neutralization Neutralizing activity Neutralizing antibody response Neutralizing antibody titer neutralizing antibody titers offer pre-fusion producing proline proline substitutions prolines reduced response S-2P SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sequence sera shown spike Spike protein spike trimer stability suggested T478K the spike protein transcript trimer trimeric Vaccine Vaccines variant variants variants of concern variants of interest VFLIP virus VOCs VOIs wildtype [DOI] 10.1016/j.antiviral.2022.105370 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of anti-SARS CoV-2 vaccine SOBERANA 02 in homologous or heterologous scheme: Open label phase I and phase IIa clinical trials동종 또는 이종 체계에서 항 SARS CoV-2 백신 SOBERANA 02의 안전성 및 면역원성: 공개 라벨 임상 1상 및 2a상 임상 시험Clinical Trial Published on 2022-07-292022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adaptive adverse event Anti-RBD IgG Antigen clinical trial clinical trials conjugate Conjugate vaccine COVID-19 COVID-19 vaccine D614G delta variant dose doses elicited ELISA evaluate evaluated frequencies Frequency hACE2 Heterologous heterologous immunization Heterologous immunization scheme homologous homologous or heterologous IgG IgG ELISA IIa immune response immune responses immunogenic immunogenicity Immunological response Interaction local pain molecular neutralization neutralized Neutralizing antibodies neutralizing antibody Open-label outcome Panel performed phase Phase I phase IIa Primary outcome progressed protocol protocols RBD receive receiving reduction reported Safe Safety SARS-CoV-2 secondary outcome selected Specific T-cell response subjects Subunit vaccine T-cell T-cell Response T-cells Tetanus tetanus toxoid trials Vaccine variant Volunteer volunteers [DOI] 10.1016/j.vaccine.2022.05.082 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 Spike Protein Vaccine-Induced Immune Imprinting Reduces Nucleocapsid Protein Antibody Response in SARS-CoV-2 InfectionSARS-CoV-2 스파이크 단백질 백신 유도 면역 각인은 SARS-CoV-2 감염에서 뉴클레오캡시드 단백질 항체 반응을 감소시킵니다Article Published on 2022-07-292022-09-11 Journal: Journal of Immunology Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료법, [키워드] anti-N antibodies anti-N antibody antibody Antibody Response Antigen antigenic B cell response COVID-19 pandemic D614G epitope Epitopes HCWs healthcare worker humoral immune immune response Imprinting Infection inhibit IQR mechanism memory memory immune response memory response mRNA vaccine mRNA vaccines N protein nucleocapsid protein OAS pathogen primary antibody Primary infection produced reduce response S protein SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection significantly lower situation spike Spike protein subject the spike protein Vaccine variant Wuhan [DOI] 10.1155/2022/8287087 PMC 바로가기 [Article Type] Article
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike설계된 이황화물은 잠긴 SARS-CoV-2 스파이크의 구조적 역학을 보여줍니다Article Published on 2022-07-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] Acidic Alter Analysis cellular compartment change changes in conformation conformational change conformations D614G D614G mutation Disulfide disulfide bond domain extracellular space functional high-resolution structure hinge interact modulate Mutation Neutral pre-fusion Protein provide RBD Receptor binding domain Regulation reveal SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spikes sequence Structure structures transition variants of concern viral fitness virion virus wild-type SARS-CoV-2 [DOI] 10.1371/journal.ppat.1010583 PMC 바로가기 [Article Type] Article
Smartphone-Based SARS-CoV-2 and Variants Detection System using Colorimetric DNAzyme Reaction Triggered by Loop-Mediated Isothermal Amplification (LAMP) with Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)Article Published on 2022-07-262022-11-16 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accuracy acute respiratory syndrome affected blind Cas9 clinical samples clinical sensitivity coronavirus COVID-19 COVID-19 patient CRISPR CRISPR-Cas9 D614G detection diagnosed Diagnosis diagnostic disease Diseases eliminated expected False-positive isothermal amplification machine learning Mutation Omicron variant Palindromic palindromic repeat patients Protein raised reaction Repeat S gene SARS-CoV-2 SARS-CoV-2 delta sensitivity Smartphone specificity System T478K the SARS-CoV-2 triggered variant variants [DOI] 10.1021/acsnano.2c04840 PMC 바로가기