damage – Page 4 – Communicable Diseases Research

Impacts of COVID-19 and SARS-CoV-2 on male reproductive function: a systematic review and meta-analysis protocol

남성 생식 기능에 대한 COVID-19 및 SARS-COV-2의 영향 : 체계적인 검토 및 메타 분석 프로토콜

Article

Published on 2022-01-052022-08-31
Journal: BMJ Open [Category] meta-analysis, SARS, 치료기술,

Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N -Acetylcysteine) Supplementation

Article

Published on 2021-12-272022-10-28
Journal: The Cochrane database of systematic reviews [Category] COVID-19,

Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19

COVID-19의 폐 배수 림프절에서 혈관 손상, 혈전 염증, 원형질모세포 활성화, T-세포 조절 장애 및 병리학적 조직구 반응

Immunology

Published on 2021-12-132022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료기술,

[키워드] accumulation Activation alveolar damage Analysis Autopsy bronchoalveolar lavage sample bronchoalveolar lavage samples CD105 CD36 collected Control COVID-19 COVID-19 case DAD damage demonstrated Depletion Diffuse alveolar damage downregulation Draining draining lymph node dysfunction dysregulated immune response dysregulation EBV enrolled Epstein Barr virus evidence of evidenced expression profiling FIBRIN FLT1 follicular follicular hyperplasia FOXP3 Gene expression profiling germinal centers herpes Herpes virus herpes viruses histology HLH immunohistochemical staining immunological immunopathology incidence infectious mononucleosis initial LEF1 lymph Lymph node lymph nodes Macrophage macrophage activation marker maturation Microarray microthrombi Migration mounted node Panel pathological pathway peribronchial Peripheral blood phenotype plasmablast plasmablasts positive PROCR provided pulmonary Reactivation response responsible Sample SARS-CoV-2 selected severe COVID-19 staining T-cell T-cell dysregulation T-cells TEK Thromboinflammation thrombosis tissue tracheal upregulation viruses vWF was performed widespread
[DOI] 10.3389/fimmu.2021.763098 PMC 바로가기 [Article Type] Immunology

Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage

COVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.

Article

Published on 2021-12-022022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

[키워드] accounted Analysis analyzed cardiac hypertrophy correlated COVID-19 COVID-19 infection COVID-19 organ damage COVID-19 patients gene expression Critical Cytokines damage deleterious effect determine downregulated downstream Effect effective Effectiveness eIF2 eukaryotic eukaryotic initiation factor 2 fibrosis Host host protein host proteins hypercytokinemia hypertrophy IL-17A IL-2 IL-6 IL-8 immune and inflammatory mechanisms of COVID-19 imperative induce Inflammation Inflammatory inflammatory genes inhibitors inhibitory initiation factor innate immune response Interaction interleukin investigation lead lung Lungs mechanism Mild moderate multiple organ failure NF-κB organ Organ failure organ injury organs overactive pathway Pathways patients peptide peptides potential therapeutic target potential therapeutic targets pro-inflammatory cytokine pro-inflammatory cytokines Profiling reduced RNAseq SARS-CoV-2 SARS-CoV-2 virus severe and critical patients severely infected patients Severity of infection single and bulk RNASeq cell profiling and analysis single-cell Stimulation suppress suppression therapeutic targets tissues translation Treatment upregulation Viral viral infection Viral protein Viral proteins viral-host protein was increased
[DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article

Clinical investigation of intestinal fatty acid-binding protein (I-FABP) as a biomarker of SARS-CoV-2 infection

SARS-CoV-2 감염의 바이오마커로서의 장지방산결합단백(I-FABP)의 임상적 조사

Article

Published on 2021-12-012022-09-11
Journal: International Journal of Infectious Diseases [Category] 바이오마커,

[키워드] Admission Biomarker Brazil C-reactive protein characteristic clinical Clinical characteristics collected Concentration correlation COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients cytokine cytokine level cytokine levels Cytokines damage demonstrated disease severity enrolled Enterocyte enterocytes epithelial cells exacerbated exhibit fatty Fatty acid gastrointestinal tract Hospital stay hospitalisation IL-6 Illness severity infected patient infected patients Inflammation Inflammatory response interferon interleukin interleukin-6 intestinal intestinal epithelial cells intestinal epithelial cells. Laboratory laboratory findings lesion lesions less nonsurvivor nonsurvivors Patient plasma poor prognosis Prognosis Protein receiver operating characteristic receiver operating characteristic curve recorded SARS-CoV-2 SARS-COV-2 infection suggested Urine
[DOI] 10.1016/j.ijid.2021.09.051 PMC 바로가기 [Article Type] Article

Germinal Center-Induced Immunity Is Correlated With Protection Against SARS-CoV-2 Reinfection But Not Lung Damage

생식기 센터 유도 면역은 SARS-CoV-2 재감염에 대한 보호와 상관관계가 있지만 폐 손상은 아닙니다

Article

Published on 2021-12-012022-09-12
Journal: The Journal of Infectious Diseases [Category] 진단,

Indications of Persistent Glycocalyx Damage in Convalescent COVID-19 Patients: A Prospective Multicenter Study and Hypothesis

Observational Study

Published on 2021-11-212022-10-04
Journal: Viruses [Category] MERS, 임상, 치료기술,

[키워드] analyzed caused controls convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Course COVID-19 COVID-19 infection COVID-19 pandemic Critical disease cross-sectional damage Degradation demonstrated disease disease course Disease progression elevated Endothelial cell endothelial damage Evidence glycocalyx healthy controls healthy individual Hospitalization hospitalized COVID-19 patient hospitalized patient hyperinflammation indication infected with SARS-CoV-2 Injury long-COVID-19 lung damage median Mild multicenter multicenter study no difference parameter persistent progression Prospective SARS CoV-2 SARS-CoV-2 significantly symptom onset Syndecan-1 virus with mild disease
[DOI] 10.3390/v13112324 PMC 바로가기 [Article Type] Observational Study

An outbreak of SARS-CoV-2 with high mortality in mink ( Neovison vison) on multiple Utah farms

여러 유타 농장에서 밍크(Neovison vison)의 사망률이 높은 SARS-CoV-2 발생

Research Article

Published on 2021-11-122022-09-12
Journal: PLoS Pathogens [Category] MERS, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Animal host animal hosts animals anorexia bat bats breadth caused Chain Reaction clinical disease collected coronavirus damage death demonstrated disease distribution early phase edema effort epithelial F486L FIVE Gross high mortality hosts Human humans In situ hybridization indicate information interstitial pneumonia Localization localized infection lower respiratory system lung Lymph node measure mink moderate molecular Mortality multiple organ multiple organs Mutation nasal turbinates necropsy Neovison Novel coronavirus occurred outbreak pathology perivasculitis polymerase chain polymerase chain reaction Polymorphisms potential transmission PPE Prevent provided pulmonary congestion Pulmonary edema RBD mutation reported reservoir reservoirs Respiratory disease respiratory tract reveal reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 viral RNA sequenced severe acute respiratory syndrome Coronavirus severe respiratory disease Spread strain susceptible symptomatic the disease The United States tissue tissues tracheobronchial Transmission unique United States upper respiratory tract Utah Vasculitis viral infection Viral RNA Viral transmission virus virus transmission while whole genome Whole genome sequencing Y453F
[DOI] 10.1371/journal.ppat.1009952 PMC 바로가기 [Article Type] Research Article

An Insight into the Role of Postmortem Immunohistochemistry in the Comprehension of the Inflammatory Pathophysiology of COVID-19 Disease and Vaccine-Related Thrombotic Adverse Events: A Narrative Review

Review

Published on 2021-11-062022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

[키워드] Adverse adverse event adverse events Affect affected approach Autopsy biochemical causal link ChAdOx1 nCoV-19 change comprehension COVID-19 COVID-19 disease DAD damage dead diffuse disease effective Effects effort helping high mortality rate histologic hypercoagulability ill patients immunohistochemistry increasingly insight Interpretation Lungs mandatory mechanism multiorgan failure narrative organ pandemic pathophysiology Patient Postmortem respiratory responsible review role SARS-CoV-2 spread of COVID-19 Therapeutic strategies thrombotic undergo vaccination Vaccine WHO World Health Organization Wuhan, China
[DOI] 10.3390/ijms222112024 PMC 바로가기 [Article Type] Review

Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19

감염성 질환 치료를 위한 면역조절제로서의 약물 전달 시스템: COVID-19와 관련성

Review

Published on 2021-11-012022-09-11
Journal: Advanced drug delivery reviews [Category] MERS, 신약개발, 진단, 치료제,

[키워드] Activation adaptive approach approaches blocking agents cellular Coagulation complement complex complex interplay COVID-19 damage drug delivery system drug delivery systems endothelial Endothelium global pandemic identify immune Immune cell immune cells Immune suppression immunomodulator immunomodulatory IMPROVE improvement Inflammasome inflammasomes Inflammation Interaction involved limit moderate to severe molecular nanomedicine not limited outcome pathogen clearance pathology pathophysiology Patient patients with moderate Prognosis Relevance SARS-CoV-2 severe COVID-19 survival rates Therapeutic approach therapeutic approaches therapeutic option therapy tissue damage
[DOI] 10.1016/j.addr.2021.113848 PMC 바로가기 [Article Type] Review