SOLVx therapeutics vaccine – Activate T-cell immunity using broad surveillance epitope strategy against mutant strains SARS-COV2SOLVx 치료제 백신 - 돌연변이 균주 SARS-COV2에 대한 광범위한 감시 에피토프 전략을 사용하여 T 세포 면역 활성화Article Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha Analysis Anti-viral B cell B cells BALB/c mice biochemical biological samples cellular coronavirus cytokine levels Cytokine storm decrease Defense develop dose Effect Efficacy and safety elevated epitope eradication euthanized Evolution functional Genome HCoV HCoV-229E hematological humoral IFN-γ IL-10 IL-6 immune response Immunoglobulin Immunoglobulin G increase in interferon gamma Laboratory lung tissue Lungs mice mRNA mutable mutant mutant strain NK cell parameter PBMC PBMCs peptide peptides Prophylactic qPCR reduced SARS-COV2 mutant significantly SOLVx statistically significant suggested Surveillance T cell T-cell immunity therapeutic TNF-alpha TNF-α treated Treatment treatment group treatment groups Vaccine virus Virus evolution virus infectivity were assessed were used [DOI] 10.1016/j.biopha.2022.113212 PMC 바로가기 [Article Type] Article
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection게놈 전체에 걸친 양방향 CRISPR 스크린은 뮤신을 SARS-CoV-2 감염을 조절하는 숙주 인자로 식별합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway Antiviral bidirectional cause clathrin conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR CRISPR screen Critical Defense defense mechanism Epigenetic epithelial cell epithelial cells expression Factor family functional highlight Highlights Host host defense human lung human lung epithelial cells identify in vitro infected individuals Infection inflammatory signaling inhibit mechanism mild respiratory modulating molecular weight mucin mucins murine models Pathways progression provide Regulation respiratory respiratory distress Respiratory illness respiratory viruses SARS-CoV-2 SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 starting point Symptom syndrome the SARS-CoV-2 TMPRSS2 transcriptional Transport Viral viral infection [DOI] 10.1038/s41588-022-01131-x PMC 바로가기 [Article Type] Article
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1SARS-CoV-2 바이러스 NSP14는 Sirtuin 1을 표적으로 하여 NRF2/HMOX1 활성화를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activate Activation acute respiratory distress acute respiratory distress syndrome antioxidant defense system antiviral activity ARDS Biliverdin catalytic domain cell type COVID-19 pandemic Cytokine storms death Defense Evidence Factor Genetic HMOX1 Host host defense inhibit interact mechanism metabolite MOST Nrf2 nsp14 oxidative stress pathway producing regulated respiratory distress Respiratory failure Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 virus significantly SIRT1 sirtuin suppressed syndrome Viral protein [DOI] 10.1038/s41423-022-00887-w PMC 바로가기 [Article Type] Article
Significant changes in follicular fluid phthalate metabolite levels reflect the lifestyle changes brought about by the strict COVID-19 lockdown in IndiaResearch article Published on 2022-08-012022-10-05 Journal: F&S science [Category] 유전자 메커니즘, [키워드] absence accumulated age analyzed BMI Care change changes in collected contributed coronavirus COVID-19 COVID-19 lockdown COVID-19 pandemic decrease Defense detect dibutyl phthalate Effect endocrine-disrupting chemicals evaluate flexible Follicular fluid group hospital human behavior hygiene in vitro In vitro fertilization include increase in India initiated injection lifestyle changes lockdown median metabolite metabolites objective Oocyte Personal protective equipment phthalates processed promoted reflect responsible screened seeking setting Significant significantly higher the median Treatment women [DOI] 10.1016/j.xfss.2022.06.001 [Article Type] Research article
Organ-specific host differential gene expression analysis in systemic candidiasis: A systems biology approach전신 칸디다증에서 기관 특이적 숙주 차등 유전자 발현 분석: 시스템 생물학 접근법Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] 유전자 메커니즘, [키워드] acquisition Activation acute phase response Analysis approach C. albicans can be used Candida Candida albican Candida albicans Candidemia candidiasis Clinical management Co-infection Complication coronavirus disease COVID-19 COVID-19 infections COVID-19 mortality Critical Defense defense mechanisms develop Differential gene expression differentially expressed gene Differentially expressed genes down-regulated drug effector cells event fungal infections hospital Host hub genes human gene human genes Immune cell immune cells immune response immune responses Infection Interaction invasive involved iron kidney leukocyte liver lymphocyte mechanisms molecular mycotic infection mycotic infections occur organ organ-specific organs pathway proliferation protocol recruitment research finding risk Scientific community severe COVID-19 infections sluggish spleen Surveillance systemic Candidiasis Systems biology therapeutic therapy yeast [DOI] 10.1016/j.micpath.2022.105677 PMC 바로가기 [Article Type] Article
Beta interferons from the extant camelids: Unique among eutherian mammals현존하는 낙타과의 베타 인터페론: eutherian 포유류 중 유일Article Published on 2022-08-012022-09-11 Journal: Developmental and comparative immunology [Category] 유전자 메커니즘, 조류인플루엔자, 치료제, [키워드] Antiviral antiviral response Beta camelid Cell cells coronavirus COVID-19 pandemic cysteine cysteines Cytopathic effect cytopathic effects Defense Dromedary Dromedary camel Endemic event expressed expression Host immune response IFN-β immune mechanism induction Infection interferon interferons invading pathogen invading pathogens kidney mammal mammals MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular offer Outbreaks pandemic pathogen Pathogens poly(I:C) poxvirus Protein recombinant IFN-β respiratory syndrome coronavirus RNA virus Treatment unique virus zoonosis zoonotic zoonotic infections [DOI] 10.1016/j.dci.2022.104443 PMC 바로가기 [Article Type] Article
NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study패혈성 쇼크 및 심각한 COVID-19 환자의 NETosis 및 뉴클레오솜 바이오마커: 관찰 연구Observational Study Published on 2022-07-272022-09-11 Journal: Biomolecules [Category] MERS, 바이오마커, 임상, [키워드] alternative Biomarker Biomarkers cell death conditions Control control subject COVID-19 Critical critical COVID-19 patient critical COVID-19 patients Defense discrimination disease severity evaluate extracellular trap histone ICU Infection Intact intensive care intensive care unit marker matched control mechanism microorganisms MPO myeloperoxidase NET NETosis NETs NETs’ formation neutrophil neutrophil activation neutrophil count Neutrophil elastase Neutrophil extracellular traps Neutrophils normalization Nucleosome nucleosomes P -value p -values patient cohort patients phagocytosis recruited Result SARS-CoV-2 septic Septic shock Significant significant differences Spread subject were measured [DOI] 10.3390/biom12081038 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl – accumulation in respiratory epitheliumSARS-CoV-2 뉴클레오캡시드 단백질은 단백질-단백질 상호작용 매개 세포내 Cl-호흡 상피에서의 축적을 통해 과염증을 유발합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 치료법, [키워드] abrogated Airway inflammation CAMP cell lines cells CFTR Concentration COVID-19 cystic fibrosis Cytokine storms Defense demonstrated depleting downregulated elicit epithelial epithelial cell epithelial cells expression fibrosis glucocorticoid Host host defense human airway epithelial hyperinflammation immune response immune responses Inflammatory response Inflammatory responses inhibition inhibitor Intracellular knockout microRNA modulating murine model murine models N protein pathogen phosphodiesterase Phosphorylation promoted Protein pulmonary inflammation raised reducing regulated respiratory epithelium resulting robust Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid second messenger selective serum SGK1 signaling pathway Smad3 structural protein suggested sustained targeting therapeutic strategy transmembrane Trigger upregulation [DOI] 10.1038/s41392-022-01048-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2’s Variants of Concern: A Brief CharacterizationSARS-CoV-2의 우려 변종: 간략한 특성Review Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha angiotensin angiotensin-2 converting enzyme B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Cell Characteristics characterization coronavirus COVID-19 COVID-19 vaccination Defense Delta Gamma Genetic Host host cell host cell receptor Immune escape immune responses immunogenic modify Mutation N-terminal new SARS-CoV-2 omicron pandemic coronavirus promote raise RBD S protein SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein variant variants variants of concern viral immune escape. virus virus transmissibility VoC VOCs [DOI] 10.3389/fimmu.2022.834098 PMC 바로가기 [Article Type] Review
Engineering ACE2 decoy receptors to combat viral escapabilityReview article Published on 2022-07-252022-10-05 Journal: Trends in pharmacological sciences [Category] COVID19(2023년), SARS, 변종, 비임상, [키워드] ACE2 ACE2 decoy receptor acute respiratory distress approach ARDS biologic cell entry Clinical studies coronavirus Coronaviruses COVID-19 decoy Defense Engineering entry receptor enzyme escape mutation Fc-receptor engagement help high-affinity mutagenesis highlight Immune cell Mutagenesis preclinical study receptor receptor protein receptors recombinant recombinant ACE2 Safe soluble ACE2 syndrome therapeutic efficacy viral escape virus [DOI] 10.1016/j.tips.2022.06.011 [Article Type] Review article