Tele-care intervention performed by parents involving specific task- environment- participation (STEP protocol) for infants at risk for developmental delay: protocol of randomized controlled clinical trial발달 지연 위험에 처한 영아를위한 특정 작업 환경 참여 (단계 프로토콜)와 관련된 부모가 수행하는 Tele-Care 중재 : 무작위 대조 임상 시험의 프로토콜Study Protocol Published on 2022-01-202022-09-10 Journal: BMC Pediatrics [Category] SARS, 임상, [키워드] activities adopted Affordance age approval assessment assessments Care carried changes clinical control group Controlled clinical trial Controlled trial COVID-19 pandemic development developmental developmental delay distribution Effectiveness Environment ethics committee experimental group Factor family finding healthcare help High-risk infants home home environment Home intervention implementation Infant Infants International Intervention measure motor National pandemic parent parents Participation peer-reviewed performed profile protocol public policies Randomized Registered risk significance level social distancing specific activities statistical analysis supplementary material Support Tele-care therapy two groups university [DOI] 10.1186/s12887-022-03126-3 PMC 바로가기 [Article Type] Study Protocol
Syncytin, envelope protein of human endogenous retrovirus (HERV): no longer ‘fossil’ in human genomeReview Published on 2022-01-122022-10-28 Journal: Animal Cells and Systems [Category] COVID-19, [키워드] acute respiratory syndrome arising Cancer caused coding coronavirus COVID-19 COVID-19 disease developmental Diseases Env envelope protein Evolution exogenous retrovirus expressed HERV HERVs Human Human genome Infection mental symptoms molecular Neurodegenerative disease Neurological diseases Pathologies Placenta Proteins reported retroviral retrovirus SARS-CoV-2 similarity syncytin the spike protein transcript Viral particles [DOI] 10.1080/19768354.2021.2019109 PMC 바로가기 [Article Type] Review
Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID제2형 당뇨병, 후기 발병 알츠하이머병 및 장기 코로나에서 엽산 매개 단일 탄소 대사 장애Review Published on 2021-12-232022-09-10 Journal: Medicina [Category] SARS, 유전자 메커니즘, [키워드] Abnormalities Alzheimer’s disease Alzheimer’s disease biochemical Biomarker biosynthetic biosynthetic pathways carbon clinical disease COVID COVID-19 cytoplasm developmental diabetes Diabetes Mellitus Diseases elevated epigenetics folate functional homocysteine hyperhomocysteinemia Impaired incorporation knowledge Long Long COVID mechanism metabolic network metabolic pathway metabolic pathways metabolism Mitochondria MTHFR gene mutations nucleus nutritional B vitamin deficiencies PASC pathology pathway progression Repurposed drugs responsible SARS-CoV-2 Stress the reader Therapeutics Treatment Type type 2 diabete Type 2 diabetes mellitus Vitamin vitamins [DOI] 10.3390/medicina58010016 PMC 바로가기 [Article Type] Review
The Impact of Maternal Anxiety on Early Child Development During the COVID-19 PandemicPsychology Published on 2021-12-222022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] adjusted Affect age Analysis Anxiety association Child Child development children clinical factors Cognition cognitive collected conducted coronavirus correlation covariate COVID-19 COVID-19 pandemic COVID-19-related fear demographics determinant developmental dominant employment examined facilitate Factor follow-up study functions Impact impacted independent indicated Infant infant development Interaction inventory Level Linear model Maternal maternal anxiety mental health Model mother outcome Perinatal mental health positive Pregnancy pregnant women prenatal prospective cohort study public health questionnaire Research selected Social support Socioeconomic Factors STAI statistical analysis Support time Variability viral infection were assessed [DOI] 10.3389/fpsyg.2021.792053 PMC 바로가기 [Article Type] Psychology
The Mediating Role of Gender, Age, COVID-19 Symptoms and Changing of Mansion on the Mental Health of Healthcare Workers Operating in Italy during the First Wave of the COVID-19 PandemicArticle Published on 2021-12-112022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Affect Anxiety Burnout changes in Changing correlation COVID-19 COVID-19 pandemic Depression developmental distress Emotional exhaustion Encouraging First wave HCW HCWs Health Health care Healthcare workers hospital intensive care unit Italy life Mansion Mediating Mediation analysis mental health observé performed Psychological distress Quality Research role Stress Symptoms tested Wave weakened worker [DOI] 10.3390/ijerph182413083 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 ACE2 and TMPRSS2 Receptor Protein Expression Patterns Throughout Gestation임신 기간 동안의 중증 급성 호흡기 증후군 코로나바이러스 2 ACE2 및 TMPRSS2 수용체 단백질 발현 패턴Article Published on 2021-12-082022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus apical surface Blood cellular coronavirus coronavirus 2 demonstrated detectable developmental early gestation Endothelium expressed expression expression pattern gestation immunohistochemistry Infection late gestation maternal blood pattern placental placental expression. pregnancies Pregnancy protein expression proteinase receptor required respiratory SARS-CoV-2 TMPRSS2 TMPRSS2 expression trophoblast [DOI] 10.1093/infdis/jiab164 PMC 바로가기 [Article Type] Article
Single cell atlas for 11 non-model mammals, reptiles and birdsArticle Published on 2021-12-062022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome Analysis anatomical Animal physiology Cell Cell signalling co-expression conserved coronavirus Critical Cross-species transmission developmental Evolutionary developmental biology expression pattern Factor gene expression profile highlighting hosts identify investigated lung cell mammals molecular evolution provide regulatory circuit reservoirs reveal RNA sequencing SARS-CoV-2 SARS-CoV-2 entry factor single-cell target cell TMPRSS2 transcriptomics viral entry zoonotic [DOI] 10.1038/s41467-021-27162-2 PMC 바로가기 [Article Type] Article
VLP-Based COVID-19 Vaccines: An Adaptable Technology against the Threat of New VariantsReview Published on 2021-11-302022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] affected antigens Beta cellular immune responses COVID-19 COVID-19 pandemic COVID-19 vaccine development Delta developmental elicit Evolution flexible Gamma humoral immune evasion immunogenic improvement increasingly morphology Mutation New other coronavirus Particle RBD robust Safe SARS-CoV-2 spike receptor-binding domain technology the spike protein threat Transmissibility Vaccine Vaccine development vaccine platform Vaccines variants of concern Variation virus virus-like particles VLP VLP vaccine VLPs VoC VOCs [DOI] 10.3390/vaccines9121409 PMC 바로가기 [Article Type] Review
Developmental Aspects of SARS-CoV-2, Potential Role of Exosomes and Their Impact on the Human TranscriptomeReview Published on 2021-11-292022-10-29 Journal: Journal of Developmental Biology [Category] COVID-19, [키워드] aspect Cell cellular children combating component connection COVID-19 COVID-19-related complication death develop development developmental diagnostic elevated Exosome Exosomes Future host tissue Human immune response immune-related genes Impact impacts Infection mother mRNA vaccine Neonate older population Outbreaks outcome pathophysiology placental placental transmission Potential predicted Pregnancy pregnant reported Research RNA-sequencing role SARS-CoV-2 spreads Stage Sub-genomic RNA therapeutic transcript Transcriptome transcriptomic Transmission upregulation Viral RNA were infected [DOI] 10.3390/jdb9040054 PMC 바로가기 [Article Type] Review
The darkest microbiome—a post‐human biosphereSpecial Issue Article Published on 2021-11-292022-10-30 Journal: Microbial Biotechnology [Category] Coronavirus, MERS, SARS, [키워드] activities activity benefit change changes in contribute COVID‐19 Deterioration develop developmental diagnostics earth effort environmental damage exceptional expand Greenhouse gas emission help Hopefully implementation less Local microbe microbial mitigate Nature problems reduce Research secure significantly stimulate survival synergy trajectory Vaccine [DOI] 10.1111/1751-7915.13976 PMC 바로가기 [Article Type] Special Issue Article