direct infection – Page 4 – Communicable Diseases Research

Can Science Help Resolve the Controversy on the Origins of the SARS-CoV-2 Pandemic?

Editorial

Published on 2021-08-022022-10-29
Journal: mBio [Category] COVID-19, Fulltext, MERS, SARS, 조류인플루엔자,

[키워드] available data Can competing COVID direct infection favor help Host hypothese Hypothesis information isolate lab mammalian origin outbreak question researcher SARS SARS-CoV-2 SARS-CoV-2 pandemic Science subject the SARS-CoV-2 unlikely
[DOI] 10.1128/mBio.01948-21 PMC 바로가기 [Article Type] Editorial

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants

Original Contribution

Published on 2021-07-052022-10-28
Journal: Basic Research in Cardiology [Category] COVID-19, Fulltext,

[키워드] ACE2 angiotensin-converting enzyme 2 B.1.1.7 B.1.351 caused Cell cellular distribution clearance Coronavirus disease 2019 COVID-19 direct infection double-stranded EDEM1 Effect Effects elevated endothelial Endothelial cell endothelial cells Endothelial dysfunction ER stress expressed Health higher risk highest Human in vitro Increased induce Infection Infectious virus Inflammation inoculated lung marker misfolded protein Mortality novel coronavirus SARS-CoV-2 P.2 Patient pro-inflammatory promote receptor reduced required responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant significantly higher Spike protein supernatant supplementary material susceptibility susceptible tested the SARS-CoV-2 the spike protein umbilical variant vascular bed Viral RNA viral spike protein virus infection virus replication Virus trapping wild type
[DOI] 10.1007/s00395-021-00882-8 PMC 바로가기 [Article Type] Original Contribution

What can cerebrospinal fluid testing and brain autopsies tell us about viral neuroinvasion of SARS-CoV-2

뇌척수액 검사와 뇌 부검을 통해 SARS-CoV-2의 바이러스 신경 침범에 대해 알 수 있는 것

Review

Published on 2021-07-012022-09-11
Journal: Journal of medical virology [Category] SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Autopsy autopsy study Brain Brainstem cause caused causes Central nervous system Cerebellum cerebrospinal cerebrospinal fluid cerebrum change Characteristics Clinical practice CNS complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CSF death detection rate diagnose direct infection documentation Evidence examined in some Infection limitations neuroinvasion Neuroinvasive Neurological symptom Neurological symptoms neurotropic Novel coronavirus olfactory pathological change pathophysiology Patient patients positive result primary symptom primary symptoms Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Viral viruses
[DOI] 10.1002/jmv.26943 PMC 바로가기 [Article Type] Review

Severe Clinical Worsening in COVID-19 and Potential Mechanisms of Immune-Enhanced Disease

Medicine

Published on 2021-06-222022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] Activation acute respiratory distress aggravate alleviate alveolar antibodies antibody Asymptomatic autoantibody candidate candidate vaccine Cell clinical Clinical deterioration contribute COVID-19 COVID-19 patient Critical Critical disease cross-reactivity direct infection disease disease severity driving dysregulated immune response Effects epithelia evaluate fatal COVID-19 help host proteins Hyperinflammatory immune cells immune response Infection inflammatory monocyte inquiry Laboratory macrophages majority mechanism Mild monocyte monocytes/macrophages NETs Neutrophil extracellular trap outcomes pathology Patient platelet apoptosis Potential producing receptor SARS-CoV-2 SARS-CoV-2 coronavirus severe COVID-19 severe disease progression severity subset Support therapeutic thrombosis Vaccines viral entry viral tropism while worsening
[DOI] 10.3389/fmed.2021.637642 PMC 바로가기 [Article Type] Medicine

Encephalopathies Associated With Severe COVID-19 Present Neurovascular Unit Alterations Without Evidence for Strong Neuroinflammation

심각한 COVID-19와 관련된 뇌병증은 강한 신경염증에 대한 증거가 없는 신경혈관 단위 변화를 나타냅니다

Article

Published on 2021-06-162022-09-12
Journal: Neurology® neuroimmunology & neuroinflammation [Category] MERS, SARS, 진단,

[키워드] acute respiratory syndrome addition albumin alteration anti-SARS-CoV-2 category caused CCL2 checked chemokines Cohort Complication Concentration control patient coronavirus correlated COVID-19 COVID-19 patient cross-sectional CSF CXCL10 CXCL8 Cytokines direct infection disease disorder elevated exhibited Factor growth factor Growth factors hepatocyte growth factor highest highlight Immunoglobulin impairment IND Inflammation Inflammatory inflammatory mediator intensive care mechanism neurologic neurologic disorders Neurovascular Patient patients patients with COVID-19 present proinflammatory mediators Quantitative replication of SARS-CoV-2 reverse transcription PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2-specific antibodies sera serum severe COVID-19 Strong Symptom systemic or local tested unit upregulation variety Vascular endothelium
[DOI] 10.1212/NXI.0000000000001029 PMC 바로가기 [Article Type] Article

Increased Creatine Kinase May Predict A Worse COVID-19 Outcome

Article

Published on 2021-04-162022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] Admission age Analysis Asia body mass index CK Cohort Comorbidities confounding factor coronavirus Course COVID-19 COVID-19 patient CPK creatine death defined direct infection discharged disease dysfunction enzyme evaluate Gender Hospitalization Hospitalized include Increased independent invasive invasive ventilation kinase majority median muscular Myopathy non-invasive ventilation Novel coronavirus outcome outcomes Patient patients Prognosis Regression retrospective cohort study SARS-CoV-2 Serum level single-center subject suggested treated two groups voluntary muscle worse prognosis
[DOI] 10.3390/jcm10081734 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

Research article

Published on 2021-04-012022-10-05
Journal: JACC: Basic to Translational Science [Category] 유전자 메커니즘,

Influence of COVID-19 on lifestyle behaviors in the Middle East and North Africa Region: a survey of 5896 individuals

Research

Published on 2021-03-302022-10-30
Journal: Journal of Translational Medicine [Category] COVID-19, SARS,

[키워드] affected Algeria amplifying Analysis Bahrain being BMI carbohydrate changes conducted coronavirus country COVID-19 COVID-19 infection COVID-19 pandemic direct infection disease females Final Health healthy identify increase in individual influence Intervention Iraq Jordan Kuwait Libya lifestyle media MENA Middle East Morocco North Oman pandemic participant physical activity Public questionnaire reduction in reported Result Saudi Arabia self-reported information significant changes in significantly smoking study population sugar supplementary material United Arab Emirates was performed worsening
[DOI] 10.1186/s12967-021-02767-9 PMC 바로가기 [Article Type] Research

Neuroinvasion of SARS-CoV-2 in human and mouse brain

인간과 쥐의 뇌에서 SARS-CoV-2의 신경 침범

Article

Published on 2021-03-012022-09-11
Journal: The Journal of Experimental Medicine [Category] SARS, 비임상, 진단, 치료기술,

Smell and taste disorders in COVID-19: From pathogenesis to clinical features and outcomes

Research article

Published on 2021-03-012022-10-05
Journal: Neuroscience letters [Category] SARS, 치료기술,