Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid proteinResearch Published on 2020-08-062022-10-30 Journal: Molecular Biomedicine [Category] COVID-19, [키워드] accelerate acute respiratory syndrome Alpha binding ability biological function C-terminal domain cellular Characteristics Complete contribute coronavirus CoV CoVs DNA double-stranded Evidence genomic RNA Health Host in vitro indicate information Interaction N protein nucleocapsid Protein Regulation Research RNA SARS SARS-CoV-2 SARS-CoV-2 nucleocapsid single-stranded single-stranded DNA Structure the N protein Viral RNA [DOI] 10.1186/s43556-020-00001-4 PMC 바로가기 [Article Type] Research
Efficacy and safety of aerosolized intra-tracheal dornase alfa administration in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS): a structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-192022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 24 hour acute respiratory distress Administered administration Aerogen Aerogen Solo® Aerosols age airway alveolar alveolar injury anticipated ARDS backbone Berlin criteria blinded blocker Breastfeeding carrier cell-free DNA citrullinated histones clearance cleave Clinical practice clinical trial comparator Compound computer-generated consecutive patient control arm coronavirus 2 coronavirus disease COVID-19 COVID-19 patients criteria damage-associated molecular pattern DAMP DAMPs diagnosed with COVID-19 dissemination distal Dornase alfa dose double-stranded DSMB Efficacy element eliminated enteral nutrition Extracellular extracellular DNA fibrosis glycemic control hospital Hospitalized hospitals hyperinflammation hypersensitivity ICU Inclusion inclusion criteria induce Inflammation intensive care interim analysis Intervention Ireland less looser lung lung damage Lungs management mechanical ventilation mechanically ventilated patient monitoring board myeloperoxidase NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps number objective Occurrence Open-label outcome PaO Paris participant Patient patients PEEP performed Pneumocytes Primary outcome progression Prone position Protective protocol randomisation randomised randomised controlled trial Randomized receive recruit recruitment reduce reducing Registered respiratory Roche Rothschild Sample size SARS-CoV-2 secretion Sedation Severe COVID-19 pneumonia severe pneumonia severity statistical analysis status study group Study protocol Switzerland syndrome to define Toxicity tracheal Treatment Trial usual care Ventilation vibrating mesh nebulizer Volume website [DOI] 10.1186/s13063-020-04488-8 PMC 바로가기 [Article Type] Letter
Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends텔로미어의 Ku 결합은 물리적 염색체 말단에서 먼 부위에서 발생Research Article Published on 2016-12-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] association bind binding Cancer caused cells chromatin chromosome chromosomes complex difficulty DNA DNA binding DNA break DNA breaks DNA replication double-stranded elements elongation End facilitate finding followed by function generate Genome hallmark independent induce interstitial lead mechanism NHEJ non-homologous occur physical predict Previous studies protein-protein interaction proximal reduce Region repair Replication replication fork reported Site solution telomerase telomere telomeres transition turn yeast [DOI] 10.1371/journal.pgen.1006479 PMC 바로가기 [Article Type] Research Article
Continuous Influx of Genetic Material from Host to Virus Populations숙주에서 바이러스 집단으로 유전 물질의 지속적인 유입Research Article Published on 2016-02-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition average Baculoviridae baculovirus baculoviruses calculate cellular Continuous Course DNA DNA sequence DNA sequences DNA sequencing DNA virus double-stranded element evaluated Frequency gene delivery genetic diversity Host host DNA hosts identify in addition to in viral infect Infection infection cycles influx insect cell insect cells Insects insertion integration majority material mechanism moth occur Population populations produced proportion Recombination repeated retrotransposons sequence Spread Support susceptible transfer transposable elements transposon vector vectors Viral viral genome viral genomes viral infection virus viruses while [DOI] 10.1371/journal.pgen.1005838 PMC 바로가기 [Article Type] Research Article
Mechanism of Nucleic Acid Unwinding by SARS-CoV HelicaseResearch Article Published on 2012-05-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid base-pair carried catalytic demonstrated determined DNA double-stranded double-stranded RNA dsDNA dsRNA Efficiency ENhance enzyme experimental evidence Helicase hydrolysis IMPROVE kinetic analysis mechanism non-structural protein Nsp12 nsp13 nucleic acid nucleotide RdRP respiratory RNA synthesis RNA-dependent RNA polymerase SARS-CoV severe viral replication virus was used [DOI] 10.1371/journal.pone.0036521 PMC 바로가기 [Article Type] Research Article
Identification of NCAM that interacts with the PHE-CoV spike proteinResearch Published on 2010-09-242022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] adhesion antibody antiviral therapies association binding blocked cDNA library Cell cells cellular cellular molecule coronavirus Critical double-stranded found identification Infection inhibited interact Interaction molecule Neural Protein required Result S glycoproteins S protein screened siRNA Spike protein T7 target target cells viral life cycle virus infection [DOI] 10.1186/1743-422X-7-254 PMC 바로가기 [Article Type] Research