ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growtharticle Published on 2017-05-312024-09-01 Journal: Protoplasma [Category] 말라리아, [키워드] ATPase DNA-interacting ligands double-stranded RNA inhibition malaria Mismatch repair [Article Type] article
Mechanism of Nucleic Acid Unwinding by SARS-CoV HelicaseResearch Article Published on 2012-05-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid base-pair carried catalytic demonstrated determined DNA double-stranded double-stranded RNA dsDNA dsRNA Efficiency ENhance enzyme experimental evidence Helicase hydrolysis IMPROVE kinetic analysis mechanism non-structural protein Nsp12 nsp13 nucleic acid nucleotide RdRP respiratory RNA synthesis RNA-dependent RNA polymerase SARS-CoV severe viral replication virus was used [DOI] 10.1371/journal.pone.0036521 PMC 바로가기 [Article Type] Research Article
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic ReticulumResearch Article Published on 2008-09-162022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] acute respiratory syndrome alteration Analysis Antiviral applied arising Author biochemical characterized complex connection coronavirus cytoplasm cytosol Defense defined dissect double-stranded RNA driven by early stage electron tomography Endoplasmic reticulum endoplasmic reticulum membrane enzyme ER membrane host cell host cell membrane host cell membranes host cells human pathogen implicated in viral induce Infected infected cell interior invagination mechanism mechanisms membrane membrane-bound membranes Microscopy network question raise replicate Replication replication complex replicative protein reported Reticulum reveal RNA RNA genome RNA synthesis RNA virus RNA viruses SARS-coronavirus SARS-CoV Structure subunits Support thought tomography ultrastructure unique Vesicle vesicles viral replication viral RNA synthesis virus Virus-host interactions Web [DOI] 10.1371/journal.pbio.0060226 PMC 바로가기 [Article Type] Research Article
A Three-Stemmed mRNA Pseudoknot in the SARS Coronavirus Frameshift SignalResearch Article Published on 2005-06-172022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] Affect Analysis antiviral drugs antiviral therapeutics assay conserved coronavirus Coronaviruses double-stranded RNA Efficiency frameshift fusion protein GenBank database Gene Expression Genetic Genome in vivo Inspection Interaction Local motif mRNA Mutation nuclear ORF1a ORF1b other coronavirus overlap predicted promote Proteins pseudoknot Region RNA RNA virus SARS virus SARS-CoV sequence signal Structure supported two-dimensional virus yeast [DOI] 10.1371/journal.pbio.0030172 PMC 바로가기 [Article Type] Research Article