ENCODE – Page 4 – Communicable Diseases Research

The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans

Article

Published on 2022-01-102022-10-04
Journal: Nature Communications [Category] 변종, 유전자 메커니즘, 치료제,

A promiscuous T cell epitope-based HIV vaccine providing redundant population coverage of the HLA class II elicits broad, polyfunctional T cell responses in nonhuman primates

Research article

Published on 2022-01-012022-10-05
Journal: Vaccine [Category] 비임상,

[키워드] alleles Antigen approach BALB/c binding CD4+ CD4+ T cell CD8+ T cell cellular immunity conserved costly Coverage COVID-19 described Diseases DNA vaccine Electroporation elicit elicited ENCODE epitope Epitope-based vaccine Epitopes Evidence facilitate generate HIV HIV vaccine HLA class II HLA-DR immune response immunization immunized immunodominant immunogen in vivo Increasing induce less MHC mice multiple epitopes Multiple HLA-binding epitopes neutralizing antibody over patients peptides platform Populational vaccine response Result rhesus macaque rhesus macaques shown T cell T cell epitope T cell response transgenic Vaccine Vaccines viral disease viral infections
[DOI] 10.1016/j.vaccine.2021.11.076 [Article Type] Research article

Microsecond molecular dynamics simulations revealed the inhibitory potency of amiloride analogs against SARS-CoV-2 E viroporin

Original Article

Published on 2021-12-312022-11-01
Journal: Genomics & Informatics [Category] COVID-19,

Rescuing the Host Immune System by Targeting the Immune Evasion Complex ORF8-IRF3 in SARS-CoV-2 Infection with Natural Products Using Molecular Modeling Approaches

분자 모델링 접근 방식을 사용하여 천연물을 사용한 SARS-CoV-2 감염의 면역 회피 복합체 ORF8-IRF3을 표적으로 하여 숙주 면역 시스템 구출

Article

Published on 2021-12-232022-09-10
Journal: International Journal of Environmental Research an [Category] SARS, 변종, 진단,

[키워드] African Analysis approaches best Bioactivity complex Compound compounds computational method Computational methods COVID-19 infection database determine disease severity Dissociation constant docking drug drugs ENCODE Endoplasmic reticulum followed by help host immune system hydrogen hydrogen bonds immune evasion immune response in silico in vitro in vivo induce inhibitor IRF3 modeling molecular molecular dynamics molecular dynamics simulations natural ORF8 pandemic performed product Protein protocol quercetin reported respiratory rutin SARS-CoV-2 South Stress System targeting Therapeutics these compound these compounds Tribuloside unique upper respiratory variant Virtual screening virus
[DOI] 10.3390/ijerph19010112 PMC 바로가기 [Article Type] Article

Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

변종 SARS-CoV-2 mRNA 백신은 마우스에서 1차 또는 부스터 시리즈로 광범위한 중화를 부여합니다.

Article

Published on 2021-12-172022-09-11
Journal: Vaccine [Category] MERS, SARS, 변종, 진단,

[키워드] (Beta) 1:1 acute respiratory syndrome acute respiratory syndrome coronavirus animals Antibody titers B.1.351 Beta booster booster dose causative agent Clinical studies coronavirus COVID-19 COVID-19 disease COVID-19 vaccine demonstrated dose effective Efficacy ENCODE evaluated global pandemic initial mice mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273.211 mRNA-1273.351 neutralization neutralization titers Neutralizing antibody titer neutralizing antibody titers Primary series respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significantly increased Spike protein susceptibility symptomatic COVID-19 disease the spike protein vaccination Vaccine vaccine efficacy Vaccine-induced immunity variant Viral viral escape wild-type
[DOI] 10.1016/j.vaccine.2021.11.001 PMC 바로가기 [Article Type] Article

Advances in the design and development of SARS-CoV-2 vaccines

Review

Published on 2021-12-162022-10-31
Journal: Military Medical Research [Category] COVID-19, Fulltext, SARS,

Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector

AcademicSubjects/SCI00010

Published on 2021-12-162022-10-31
Journal: Nucleic Acids Research [Category] COVID-19, SARS,

[키워드] activated activating Activation amplification binding complex CRISPR degrade dependent on detect DNA DNase domain ENCODE extrinsic generate guide RNA Immunity in vivo lack limit of detection locus Nuclease nucleic acid nucleotide position plate reader resulting RNA RNA secondary structure robust sensitivity sequence specificity stimulate subunit the SARS-CoV-2 virus Type type III variety Vibrio
[DOI] 10.1093/nar/gkab1190 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010

Development of a Single-Cycle Infectious SARS-CoV-2 Virus Replicon Particle System for Use in Biosafety Level 2 Laboratories

Virus-Cell Interactions

Published on 2021-12-012022-10-30
Journal: Journal of Virology [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] 3CL activity acute respiratory syndrome addition anti-CoV drug antiviral drug antiviral drugs biosafety Biosafety Level 2 Biosafety Level 3 BSL2 BSL3 Cell cell types conditions contagious coronavirus CoV decrease deleting development drug dose ENCODE expressing expression fluorescent GFP glycoprotein glycoprotein G host cells Immunity Infection Laboratory lack murine mutant neutralized Particle platform Protease inhibitor Protein Remdesivir replication of SARS-CoV-2 replicon reporter reporters Research robust S gene SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 research SARS-CoV-2 virus Scientific community serum spike gene Support System Treatment Vaccine variety vesicular stomatitis virus viral envelope viral genome viral glycoproteins VSV
[DOI] 10.1128/jvi.01837-21 PMC 바로가기 [Article Type] Virus-Cell Interactions

Drug repurposing in COVID-19: A review with past, present and future

Research article

Published on 2021-12-012022-10-05
Journal: Metabolism Open [Category] 신약개발, 임상, 치료제,

[키워드] ACE2 Applying approach approaches approved cause clinical conditions clinical trials conducted coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 disease COVID19 drug Drug repurposing effective Effectiveness ENCODE Favipiravir FDA food Genome global public health host cell surface identify in vitro infection process initiate Interaction molecular docking problems protease inhibitors Protein Protein structure‐based drug design Remdesivir reuse ribavirin Ritonavir RNA virus SARS CoV2 SARS-CoV2 shown single-stranded positive-sense spike structural proteins therapeutic agent Tocilizumab treat
[DOI] 10.1016/j.metop.2021.100121 [Article Type] Research article

The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine Coronavirus

Pathogenesis and Immunity

Published on 2021-11-242022-10-30
Journal: Journal of Virology [Category] COVID-19, MERS,

[키워드] Accessory accessory protein accessory protein 8b accessory proteins addition Affect antiviral immune response beta coronavirus C-terminal contribute coronavirus CoV CoVs demonstrated ENCODE Endoplasmic reticulum ENhance enhanced Essential expressing FIVE Genome global public health Hepatitis high variability Host IFN-I in vitro in vivo infected cells inhibit inhibitory effect innate immune response Innate immunity interfere introduced membrane MERS-CoV MERS-CoV infection methionine MHV mice Middle East mouse mouse hepatitis virus Multiple murine N-terminal domain not affect ORF8b Pathogenesis Protein protein 3 Region regulate renal Replication respiratory respiratory syndrome coronavirus responsible RNA-seq analysis SARS-CoV SARS-CoV-2 severe pneumonia severe respiratory infection shown significantly threat type I interferon variant viral replication Viral virulence virulence virus
[DOI] 10.1128/JVI.01842-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity