RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cellsRNA 편집은 인간 숙주 세포에서 SARS-CoV-2의 뉴클레오티드 다양성을 증가시킵니다Article Published on 2022-03-302022-09-11 Journal: PLoS Genetics [Category] SARS, 유전자 메커니즘, [키워드] binding affinity bioinformatic analysis Bronchoalveolar lavage fluid Characteristics Clustering COVID-19 pandemic COVID-19 patients COVID-19 research Critical enrichment Evolution of SARS-CoV-2 human host cell human host cells human lung cells implication increase Local mechanism metatranscriptomic nucleotide Phylogenetic analysis positive-sense predicted responsible RNA RNA modification RNA secondary structure RNA virus robust SARS-CoV-2 secondary structure single-stranded RNA virus Vaccine development virus [DOI] 10.1371/journal.pgen.1010130 PMC 바로가기 [Article Type] Article
CD8 + T Cell Senescence: Lights and Shadows in Viral Infections, Autoimmune Disorders and CancerCD8 + T 세포 노화: 바이러스 감염, 자가면역 장애 및 암의 빛과 그림자Review Published on 2022-03-212022-09-11 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, 바이오마커, [키워드] Adaptive immune response addition Ageing Antigen Autoimmune Autoimmune disease Autoimmune diseases autoimmune disorder Autoimmune disorders Cancer cause caused CD28 CD28− CD57+ CD8+ T cells CD57 CD8 CD8+ Cell circulating clearance CMV condition contributing to cytotoxic function Diseases Effect Efficacy enrichment exacerbate favor function functions heterogeneous HIV immune-senescence immunological immunotherapies Immunotherapy implication IMPROVE Infection inflammaging inflammaging. life LIGHT low-grade inflammation lowering Lymphocytes memory Memory cells novel antigen novel antigens pathogen Pathogens phenotype Prevent progression reduction SARS-CoV-2 senescent shadow Stress switching T cell T cells T lymphocyte T lymphocytes the disease thymic Transformed cell transformed cells Tumor tumor microenvironment turn Vaccine vaccine efficacy Viral viral infection viral infections [DOI] 10.3390/ijms23063374 PMC 바로가기 [Article Type] Review
Hydrophobic Localized Enrichment of Co-reactants to Enhance Electrochemiluminescence of Conjugated Polymers for Detecting SARS-CoV-2 Nucleocapsid ProteinsSARS-CoV-2 뉴클레오캡시드 단백질 검출을 위한 공액 중합체의 전기화학발광을 향상시키기 위한 공반응물의 소수성 국소 농축Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료법, [키워드] antibody Antigen biosensor capture antigen carbon carboxyl complexes Conjugated Detection limit ECL Electrochemiluminescence enrichment hydrophobic inspiration Localized metal ion metal ions platform PNP Polymer propylamine Protein reactants SARS-CoV-2 SARS-CoV-2 nucleocapsid secondary antibody sensitivity [DOI] 10.1021/acs.analchem.1c05407 PMC 바로가기 [Article Type] Article
Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients통합 멀티오믹스 및 in silico 분석은 경증 및 중증 COVID-19 환자에서 ARHGEF1 및 선별된 길항제의 역할을 밝혔습니다.Article Published on 2022-03-012022-09-11 Journal: Journal of cellular biochemistry [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anticancer Antiviral ARHGEF1 association Biotechnology caused center co-expression co-expression network Compound computational tool computational tools coronavirus COVID-19 database DEGs determine differentially expressed gene Differentially expressed genes disease effective therapy ENhance enrichment expressed expression profile gene co-expression network Gene ontology group guanine identify in silico analysis In silico methods in vitro in vivo infected patients inherent Medicines messenger Messenger RNA Mild molecular molecular docking molecular dynamics MSI-DEGs nucleotide number of infected Ontology overlapping pathogenic pathway patients worldwide protein-protein interaction rapid increase required Research SARS-CoV-2 SARS-CoV-2 patients screened severe acute respiratory syndrome Coronavirus severe COVID-19 patient Severity of infection stratified target therapeutic drug therapeutic efficacy therapeutic target therapy virus [DOI] 10.1002/jcb.30213 PMC 바로가기 [Article Type] Article
Centrifugal Microfluidic Method for Enrichment and Enzymatic Extraction of Severe Acute Respiratory Syndrome Coronavirus 2 RNA중증 급성 호흡기 증후군 코로나바이러스 2 RNA의 농축 및 효소 추출을 위한 원심 미세 유체 방법Article Published on 2022-02-222022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification analyst analyzed applicability buffer capsid Centrifugal Chain Reaction comparable complex controls coronavirus coronavirus 2 demonstrated development Diagnosis diagnostics downstream effective ENhance enrichment exposure to extraction imperative in viral inhibit Intervention Isolation lysed nasopharyngeal Nasopharyngeal swab nucleic acid nucleic acids Particle pathogen detection pathogenic Pathogens platform polymerase chain polymerase chain reaction positive purification real-time reverse transcriptase real-time RT-PCR removal respiratory reverse transcriptase Reverse transcriptase polymerase chain reaction RNA RNA extraction robust RT-PCR Saliva Sample SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 virion severe acute respiratory syndrome Coronavirus Surveillance Transmission Transport media Treatment tube Viral RNA viral transport media virus [DOI] 10.1021/acs.analchem.1c05215 PMC 바로가기 [Article Type] Article
Capacitive Aptasensor Coupled with Microfluidic Enrichment for Real-Time Detection of Trace SARS-CoV-2 Nucleocapsid Protein미량 SARS-CoV-2 뉴클레오캡시드 단백질의 실시간 검출을 위한 미세유체 농축과 결합된 용량성 압타센서Article Published on 2022-02-152022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antigen detection body fluid bottleneck bottlenecks caused coronavirus detection Diagnosis enrichment limit of detection linear milliliter nucleocapsid protein pandemic Quantitative SARS-CoV-2 sensitivity sensor severe acute respiratory syndrome Coronavirus Spread Stemming trace virus detection [DOI] 10.1021/acs.analchem.1c04296 PMC 바로가기 [Article Type] Article
Diet quality during the COVID-19 pandemic: Effects of workplace support for families and work-to-family enrichment in dual-earner parents with adolescent childrenArticle Published on 2022-02-012023-07-07 Journal: Appetite [Category] COVID19(2023년), [키워드] Actor-partner interdependence model adolescents Diet quality Dual-earner couples enrichment Work resources. [DOI] 10.1016/j.appet.2021.105823 PMC 바로가기
Luteolin Potentially Treating Prostate Cancer and COVID-19 Analyzed by the Bioinformatics Approach: Clinical Findings and Drug Targets전립선암 및 COVID-19를 잠재적으로 치료하는 루테올린, 생물정보학 접근법으로 분석: 임상 결과 및 약물 표적Endocrinology Published on 2022-02-012022-09-11 Journal: Frontiers in Endocrinology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Anti-inflammatory effects anticancer bioinformatics characterized clinical clinical feature conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment curative demonstrated Differential gene expression downregulated gene drug drug target Efficiency enhancement enrichment Epidemic evidenced expression finding FOS function Genes Immunity Infection Luteolin malignancies mechanism metabolism molecular docking MPO Mutation network pharmacology Patient patients pharmacological mechanism Prostate cancer RNA sequencing SARS-COV-2 infection signaling pathways target targets the SARS-CoV-2 treating Treatment Vaccine was determined [DOI] 10.3389/fendo.2021.802447 PMC 바로가기 [Article Type] Endocrinology
Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19중요한 COVID-19에서 심장 손상 및 미세 혈전에 대한 임상 조직 병리학 및 단일 핵 RNA 시퀀싱 통찰력Clinical Trial Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 임상, 진단, 치료기술, 치료제, [키워드] Acute cardiac injury Analysis antiplatelet association bioinformatics Biomarkers biomarkers of inflammation C-reactive protein cardiac injury Cardiology cardiovascular disease cause clinical factors Cohort conducted controls Corticosteroid corticosteroid treatment COVID-19 Critical enrichment erythrocyte sedimentation erythrocyte sedimentation rate etiology Extracellular matrix Features fibrinolysis fibroblast heart hearts identify In-hospital increased mortality Injury microthrombi Molecular pathology myocarditis Necrosis New York City pathophysiology Patient potential therapeutic target prevalent Prospective Study RNA-sequencing sedimentation rate Sequencing analysis Signaling tested therapeutic anticoagulation Therapies therapy transcriptomic were used [DOI] 10.1172/jci.insight.154633 PMC 바로가기 [Article Type] Clinical Trial
Contribution of magnetic particles in molecular diagnosis of human virusesArticle Published on 2022-01-212023-06-14 Journal: Talanta [Category] COVID19(2023년), MERS, SARS, [키워드] detection enrichment extraction Magnetic nanoparticles viruses [DOI] 10.1016/j.talanta.2022.123243 PMC 바로가기 [Article Type] Article