Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptorsResearch Article Published on 2020-05-282022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] ACE2 airway ANPEP artificial intelligence association ciliated cell club cell coronavirus correlated COVID-19 COVID-19 pandemic DPP4 Enterocyte epithelial cells expression profiling Gut hotspot Human hypotheses knowledge machine learning maturation mechanism natural language processing olfactory Pathogenesis platform proteomics receptor reservoir RNA-Seq SARS-CoV-2 single cell RNA-seq Single-cell RNA-sequencing small intestine the SARS-CoV-2 tissue tongue transcriptional [DOI] 10.7554/eLife.58040 PMC 바로가기 [Article Type] Research Article
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytesResearch Article Published on 2020-05-132022-10-28 Journal: Science Immunology [Category] COVID-19, Fulltext, SARS, [키워드] ACE2 colonic contribute COVID-19 patients Disease progression Enterocyte facilitated fecal Gastrointestinal highlight host cells inactivated infect Infection Infectious virus intestinal intestinal enterocyte intestinal lumen intestine Local promote promoted released replicate SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 virus serine proteases specimen Stool Symptom systemic illness TMPRSS2 TMPRSS4 Transmission virus virus entry [DOI] 10.1126/sciimmunol.abc3582 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 productively infects human gut enterocytesResearch Article Published on 2020-05-012022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS, [키워드] ACE2 Analysis clinical evidence coronavirus disease Coronavirus infection COVID-19 demonstrated disease Enterocyte enterocytes enzyme expressed human gut enterocyte infect intestinal epithelium intestinal organoid intestine lung mRNA expression organ receptor respiratory route SARS-CoV SARS-CoV-2 SARS-CoV-2 replication Support the SARS-CoV-2 thought Transmission viral particle virus [DOI] 10.1126/science.abc1669 PMC 바로가기 [Article Type] Research Article
Role of Porcine Aminopeptidase N and Sialic Acids in Porcine Coronavirus Infections in Primary Porcine EnterocytesArticle Published on 2020-04-052022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] acid aminopeptidase aminopeptidase N APN cells cellular cellular receptor Coronavirus infections Coronaviruses correlated determinant Efficiency Enterocyte enterocytes epidemic diarrhea expression gastroenteritis had no higher infectivity Infection Miller PEDV porcine coronavirus porcine epidemic diarrhea virus (PEDV) positive positive cell receptor replicated reported role Seven sialic acid sialic acids significant increase significantly susceptibility TGEV Transmissible gastroenteritis virus (TGEV) Treatment virus [DOI] 10.3390/v12040402 PMC 바로가기 [Article Type] Article
Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signalingArticle Published on 2020-01-202022-11-01 Journal: Cell Death & Disease [Category] Coronavirus, MERS, [키워드] accelerated aminopeptidase N APN Cell contrary crypt cell decrease described diarrheal differentiation Disease model disrupt Enterocyte Factor gastroenteritis Goblet cell goblet cells greater homeostasis Hypothesis inactivation Infection inhibit intestinal intestinal stem cell Invasion mechanism mitochondrial mucin Notch occur Paneth cell Pathogenesis pathway promoted Protein provided receptor regulate Replication ROS secretion Self-renewal Signaling Stem-cell differentiation Stem-cell niche target TGEV therapeutic transmissible gastroenteritis virus virus virus infection [DOI] 10.1038/s41419-020-2233-6 PMC 바로가기 [Article Type] Article
Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection생체공학적 인간 장기 칩이 시겔라 감염에 영향을 미치는 장 미세환경과 기계적 힘을 드러낸다Article Published on 2019-09-112024-08-22 Journal: Cell Host & Microbe [Category] 세균성이질, [키워드] Enterocyte Gut-on-Chip host-pathogen interactions intestine Intestine-Chip microengineering organ-on-chip Peristalsis Shear stress stretching.
A Single V672F Substitution in the Spike Protein of Field-Isolated PEDV Promotes Cell–Cell Fusion and Replication in VeroE6 CellsArticle Published on 2019-03-202022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid amino acid residue aminopeptidase N Analysis cell lines cell–cell fusion cells characterized chimeric chimeric proteins Critical demonstrated Efficiency Enterocyte epidemic diarrhea expressing fusion host cells Huh-7 cells identify induce infect Mutation Neonatal passages PEDV RBD receptor Receptor binding domain receptor preference replaced replicate responsible S protein S proteins S1/S2 cleavage site single mutation spike Substitution Syncytia syncytium syncytium formation the RBD the Spike the spike protein triggered variant VeroE6 cell virus while [DOI] 10.3390/v11030282 PMC 바로가기 [Article Type] Article
Resistance to coronavirus infection in amino peptidase N-deficient pigsOriginal Paper Published on 2018-10-122022-10-28 Journal: Transgenic Research [Category] Coronavirus, [키워드] absence age alphacoronaviruses ANPEP caused collected coronavirus Coronavirus infection CRISPR/Cas9 disease Disease resistance Enterocyte enterocytes epidemic diarrhea evaluated gastroenteritis Genetic implication Infection knockout morbidity and mortality Necrosis Neonatal PCR PEDV phenotype premature stop codon putative receptor reactivity receptor resistance resulting retained supplementary material Support susceptibility Swab TGEV Viral receptor virus virus nucleic acid was determined wild type [DOI] 10.1007/s11248-018-0100-3 PMC 바로가기 [Article Type] Original Paper
Establishment of porcine enterocyte/myofibroblast co-cultures for the growth of porcine rota- and coronavirusesArticle Published on 2018-10-122022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] bovine can be used Cell Characteristics co-culture co-cultured contributing to coronavirus Culture demonstrated enteric virus Enterocyte epithelial cells evaluated Extracellular matrix fecal fetal Genotype growth growth factor infect Last Miller PEDV proliferation Replication rotavirus strain secrete serum strain subepithelial susceptibility susceptible TGEV Vero viruses [DOI] 10.1038/s41598-018-33305-1 PMC 바로가기 [Article Type] Article
MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic StressMK2-의존성 p38b 신호는 만성 스트레스 하에서 JNK 유도 세포자멸사로부터 Drosophila Hindgut Enterocytes를 보호합니다Research Article Published on 2011-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addressed affected antimicrobial peptides Apoptosis atrophy Author branch cascade Cell chronic complex component contribute damage damaged descendants Deterioration Diseases Drosophila Elimination Enterocyte enterocytes epithelial epithelium event form genetic analysis Gut Hindgut homeostasis Impaired induce integrity intestinal Intestinal diseases intestinal epithelium intestinal stem cell Intestinal stem cells JNK kinases leads less manifested pathogen Pathogens pathway peptides peptides) Prevent proliferation PROTECT Protective Protein protein kinase replaced REPLACED BY Replenishment required salt Signal transduction stem cell stem cells Stress Stressor stressors subsequent suppresse Trigger triggers upregulated upstream [DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article