SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike ParticlesSARS CoV-2 핵단백질은 렌티바이러스 스파이크 입자의 감염성을 향상시킵니다Cellular and Infection Microbiology Published on 2021-04-232022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 치료법, [키워드] ACE2 ACE2-Fc BSL-2 cells cellular entry D614G enhancer Entry inhibitor entry inhibitors fused Genes implication Infectivity Interpretation lentiviral less mutant N protein Neutralizing neutralizing effect nucleocapsid nucleoprotein ORF Particle particle infectivity Particles pathogen performed produced SARS CoV SARS CoV-2 SARS-CoV-2 spike spike lentiviral pseudotyping Spike protein the spike protein virion virions Virus neutralization while wild-type [DOI] 10.3389/fcimb.2021.663688 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption InhibitorsArticle Published on 2021-04-122023-06-02 Journal: Viruses [Category] B형 간염, [키워드] ASBT bile acid transport Entry inhibitor HBV HDV NTCP Structure-activity relationship [DOI] 10.3390/v13040666 PMC 바로가기 [Article Type] Article
A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical SamplesOriginal Research Published on 2021-03-302023-07-01 Journal: American Journal of Respiratory Cell and Molecular [Category] SARS, [키워드] COVID-19 Entry inhibitor SARS-CoV-2 Spike protein Surfactant protein D [DOI] 10.1165/rcmb.2021-0005OC PMC 바로가기 [Article Type] Original Research
Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitorsSARS-CoV-2 세포 진입 억제제로서의 Morus Alba의 막횡단 프로테아제 세린-2 억제제의 약리정보학 기반 식별Original Article Published on 2021-03-302022-09-12 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 진단, [키워드] Morus alba Linn. Abstract acute respiratory syndrome coronavirus aerodigestive tract ambroxol Amino acid amino acids analyses approach AutoDock vina binding affinity binding free energy calculated camostat complex component drug-likeness Entry inhibitor epithelial cell epithelial cells expressed FIVE free energy Glide help host cell hydrogen Hydrogen bond hydrophobic hydrophobic interaction hydrophobic interactions in-silico Infection inhibitor Interaction ligands MD simulation molecular molecular docking molecular dynamics molecule molecules Morus Alba Novel coronavirus parameter pharmacokinetic protease Protein respiratory SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection screened Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific tissue specific tissues stability suggested supplementary material the SARS-CoV-2 TMPRSS2 trajectory transmembrane Virtual screening were assessed [DOI] 10.1007/s11030-021-10209-3 PMC 바로가기 [Article Type] Original Article
Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acidArticle Published on 2021-01-012023-06-11 Journal: American journal of physiology. Gastrointestinal and liver physiology [Category] B형 간염, [키워드] Entry inhibitor HBV NTCP taurolithocholic acid trans-inhibition. [DOI] 10.1152/ajpgi.00263.2020
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids폐 및 결장 오르가노이드를 이용한 SARS-CoV-2 억제제 식별Article Published on 2021-01-012022-09-11 Journal: Nature [Category] MERS, SARS, 바이오마커, 신약개발, 진단, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar approved Cell cell types cells chemokine chemokines colonic complementary coronavirus COVID-19 COVID-19 therapeutics Disease model disease models drug Drug administration Drug screening enterocytes Entry inhibitor entry inhibitors Express facilitate FDA food hPSC-derived colonic organoid human disease identification identify Imatinib infect inhibited inhibitor lung Manifestations mycophenolic acid Organoid outcome Patient patients with COVID-19 performed pluripotent stem cell quinacrine respiratory respiratory tract robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus significantly stem cells These data US Food and Drug Administration valuable resource [DOI] 10.1038/s41586-020-2901-9 PMC 바로가기 [Article Type] Article
An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2Article Published on 2020-12-222023-07-13 Journal: Cell Reports [Category] SARS, [키워드] ACE2 transgenic coronavirus D614G Entry inhibitor Fc fusion lentiviral pseudotype microbody SARS-CoV-2 soluble ACE2 Spike protein [DOI] 10.1016/j.celrep.2020.108528 PMC 바로가기
Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experimentResearch article Published on 2020-11-012022-10-05 Journal: Journal of molecular graphics & modelling [Category] SARS, 신약개발, [키워드] ACE2 approved Cell clinically cofactor Contact COVID-19 COVID-19 outbreak Critical disease docked drug drug candidate drug library drug repositioning drugs Entry inhibitor enzyme experiment exterior generate human ACE2 in silico inhibitor inhibitors Initially insight introduced Ligand ligands mechanism membrane-bound molecular molecular docking peptide protective role receptor residue SARS-CoV-2 screened shifting therapeutic therapeutic target Virtual screening [DOI] 10.1016/j.jmgm.2020.107697 [Article Type] Research article
SARS-CoV-2 and Three Related Coronaviruses Utilize Multiple ACE2 Orthologs and Are Potently Blocked by an Improved ACE2-IgArticle Published on 2020-08-262023-07-01 Journal: Journal of Virology [Category] SARS, [키워드] ACE2 ACE2-Ig Entry inhibitor host range SARS-CoV-2 [DOI] 10.1128/JVI.01283-20 PMC 바로가기
SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host CellsReview Published on 2020-08-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE2 Antiviral approach cathepsin Cathepsins complementary conserved coronavirus CoV COVID-19 direct-acting antiviral effort Entry inhibitor Evolution of SARS-CoV-2 Factor heptad repeat Host HRs Infection inhibit Interaction investigated involved membrane fusion molecule pandemic peptides inhibitors Protein RBD Receptor binding domain related viruses SARS-CoV-2 SARS-CoV-2 entry inhibitors Scientific community small molecules inhibitors spike targeting the S protein the Spike TMPRSS2 viral entry viral infections virus virus entry [DOI] 10.3390/ijms21165707 PMC 바로가기 [Article Type] Review