SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells1차 인간 기도 상피 세포에서 SARS-CoV-2 비리온 감염성과 사이토카인 생산Article Published on 2022-05-022022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Activation Alpha B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 BavPat1 Behavior Beta Cell cultures cytokine D614G mutation epithelial epithelial cell epithelial cells Evidence Ex vivo hAEC Human human airway human airway epithelial infect Infectivity Innate immunity isolate lack Lineage lineages new SARS-CoV-2 no difference observé Omicron variant Omicron variants organotypic model Physiology primary human airway Primary human airway epithelial cells Production provide replacement replicate respiratory tissue respiratory tissues SARS-CoV-2 SARS-CoV-2 variants variant variants variants of concern virion virus vRNA [DOI] 10.3390/v14050951 PMC 바로가기 [Article Type] Article
Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replicationSARS-CoV-2에 대한 기도 상피 인터페론 반응은 리노바이러스보다 열등하고 이종 라이노바이러스 감염은 SARS-CoV-2 복제를 억제합니다Article Published on 2022-04-282022-09-11 Journal: Scientific Reports [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료제, [키워드] addition AEC airway airway epithelial cell airway epithelial cells airway epithelium alphacoronavirus Betacoronavirus biosafety level Biosafety Level 3 bronchial BSL-3 cell lysate cell lysates children common Concentration correlated Culture cultures CXCL10 Delta delta variant Donor elicit epithelial epithelial cells evade Ex vivo experiment Gene Expression generate greater heterogeneity Heterologous highly pathogenic HRV IFN IFN response IFN-β IFN-λ IFNB1 induce Infection interferon interferon response less level 3 Older omicron Protein recombinant IFN recombinant IFN-β reduce reduced replicated response responses rhinovirus RNA robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly subset supernatant suppresse Treatment type I variant variants viral replication was collected were infected [DOI] 10.1038/s41598-022-10763-2 PMC 바로가기 [Article Type] Article
Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum IsolatesArticle Published on 2022-04-192024-08-28 Journal: Med Instrum [Category] 말라리아, [키워드] Antimalarials cold storage drug susceptibility Ex vivo growth malaria Plasmodium falciparum Uganda
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19Research article Published on 2022-04-142022-10-05 Journal: Blood advances [Category] SARS, 바이오마커, 비임상, [키워드] activated Activation aggregate amplification amplify amplifying Analysis approach assays binding CD16 Coagulation Combination COVID-19 Critically ill patient driving Evidence Ex vivo exhibited expression fibrinogen function functional high risk highlight HLA-DR hypercoagulability hyperinflammation identify in vitro indicated Inflammation Inflammatory Inflammatory cytokine Inflammatory mediators inflammatory monocyte Interaction interleukin-1β life-threatening mechanism mechanisms monocyte P-selectin pathogenesis of COVID-19 Patient pharmacological Platelet platelet activation Platelets presenting proinflammatory cytokines receptor response RNA-sequencing SARS-COV-2 infection secretion severe COVID-19 Signaling single-cell subset thromboembolic complications Thromboinflammation tissue tumor necrosis factor-α with COVID-19 [DOI] 10.1182/bloodadvances.2021006680 [Article Type] Research article
The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivoCOVID-19 무증상 환자의 혈청은 생체 외 순환하는 혈관 신생 세포에서 내피 기능 장애 및 바이러스 반응과 관련된 단백질을 상향 조절합니다Article Published on 2022-04-092022-09-12 Journal: Molecular Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] Activation acute respiratory syndrome applied approach Asymptomatic Asymptomatic COVID-19 asymptomatic individual Asymptomatic individuals asymptomatic patient caused Cell cellular change circulating Circulating angiogenic cells Coagulation coronavirus correlated COVID-19 COVID-19 negative critical COVID-19 patients death Donor donors endothelial Endothelial dysfunction Endothelial progenitor cells evaluated Ex vivo Factor highest ICAM-1 identify IgG immune response incubated individuals Infection infective Inflammatory Inflammatory response inhibitor initial machine learning algorithm marker pathway PCR platform positive potential long-term sequelae promote promoted Protein protein level proteomics provoke Quantitative responsible SARS-CoV-2 SARS-COV-2 infection serum significantly Stage Symptoms Thromboembolic event TLR2 transmissions treated triggered understanding up-regulate up-regulated Vascular Vascular damage viral infection virus virus entry while [DOI] 10.1186/s10020-022-00465-w PMC 바로가기 [Article Type] Article
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells Research Published on 2022-04-052022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Antigen booster Breakthrough infection CD8+ T cell characterized coronavirus distribution Effect effectors Efficacy elicit Evidence Ex vivo expand exposure histocompatibility complex Human individual Infection memory memory T cell monoclonal motifs mRNA vaccine phenotype Primary infection protocol receptor repeated responses SARS-CoV-2 SARS-CoV-2 antigen sequence severe coronavirus disease Single-cell RNA sequencing specificity spike-specific T cell T cell T cell memory TCR vaccination variant [DOI] 10.1038/s41590-022-01184-4 [Article Type] Research
A targetable ‘rogue’ neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS표적화 가능한 '불량' 호중구 하위 집합인 [CD11b+DEspR+] 면역형은 급성 호흡 곤란 증후군(ARDS) 및 COVID-19-ARDS의 중증도 및 사망률과 관련이 있습니다Article Published on 2022-04-042022-09-11 Journal: Scientific Reports [Category] 바이오마커, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome antibody Apoptosis ARDS arise assays association blocked Critical death detect dual dysregulated Endothelin Ex vivo expressing humanized identify IgG4 immunotype induce induction of apoptosis inhibitor inhibitors insufficiency internalization kill Ligand lung tissue MOF monocyte Monocytes Mortality NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps neutrophil function Neutrophils pathogenic Pathogens Patient peptide pleiotropic progression receptor respiratory distress Respiratory distress syndrome rhesus scRNA-seq severity syndrome Therapeutic approach tissue injury [DOI] 10.1038/s41598-022-09343-1 PMC 바로가기 [Article Type] Article
DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonistsDAMP/PAMP는 COVID-19 환자에서 단핵구 TLR 활성화 및 내성을 유도합니다. 핵산 결합 스캐빈저는 이러한 TLR 작용제에 대항할 수 있습니다.Article Published on 2022-04-012022-09-12 Journal: Biomaterials [Category] COVID19(2023년), SARS, 진단, [키워드] Activation agonist anti-viral response binding Blood CD16 COVID-19 COVID-19 patient COVID-19 patients damage Deceased Ex vivo hallmark hyperactivate Hyperactivation hyperinflammation Hyperstimulation ICU ICU patient immunopathology induce Infection Inflammation innate immune intensive care unit limit lung Lungs Major-biological sciences Minor-immunology and inflammation. monocyte Monocytes neutralize nucleic acid outcome patients pattern phenotype proteomics receptors RNA-sequencing SARS-CoV-2 Signaling systemic inflammation the patient TLR TLR agonist TLR stimulation Tolerance Toll-like receptor Treatment viruses [DOI] 10.1016/j.biomaterials.2022.121393 PMC 바로가기 [Article Type] Article
Kinetics of immune responses to the AZD1222/Covishield vaccine with varying dose intervals in Sri Lankan individuals스리랑카 개인에서 다양한 투여 간격으로 AZD1222/Covishield 백신에 대한 면역 반응의 동역학Article Published on 2022-04-012022-09-11 Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] age antibodies antibody Antibody titer Antibody titers AZD1222 Cohort cohorts correlated COVID-19 dose dosing intervals dosing schedule ELISPOT ELISpot responses Ex vivo first dose group hemagglutination assay IFNγ immune response immune responses immunogenecity individual interferon interval Kinetics magnitude median no difference positive positive response post vaccination RBD Receptor-binding domain response responses SARS-CoV-2 virus second dose significantly significantly higher Spearman T cell T cell response T cells the RBD the receptor-binding domain the SARS-CoV-2 virus threshold total antibodies total antibody Vaccine Vaccines variants variants of concern virus VoC VOCs were assessed were measured [DOI] 10.1002/iid3.592 PMC 바로가기 [Article Type] Article
Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19COVID-19의 기관 흡인물에서 BromAc의 생체 외 점액 용해 및 항염 활성Article Published on 2022-04-012022-09-12 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), MERS, SARS, 신약개발, 임상, 진단, 치료제, [키워드] Acetylcysteine anti-inflammatory activity anti-inflammatory effect BromAc caused chemokine collected Combination Concentration COVID-19 COVID-19 patient COVID-19 patients Critically ill CXCL8 Cytokine analysis Cytokine storm dose drug evaluated Ex vivo G-CSF IL-10 IL-13 IL-5 IL-6 IL-9 IP-10 lethal disease MCP-1 mechanical ventilation MIP-1b mucolysis mucolytic Mucolytic therapy NAC pandemic pharmacological treatment public health threat reducing reduction reduction in regulatory cytokine Respiratory disease robust SARS-CoV-2 sputum therapeutic options tracheal tracheal aspirate treat was performed [DOI] 10.1016/j.biopha.2022.112753 PMC 바로가기 [Article Type] Article