In Vitro and In Vivo Models to Study the Zoonotic Mosquito-Borne Usutu VirusReview Published on 2020-09-302023-05-31 Journal: Viruses [Category] Fulltext, 조류인플루엔자, [키워드] experimental model in vitro in vivo Pathogenesis USUV [DOI] 10.3390/v12101116 PMC 바로가기 [Article Type] Review
Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2Immunology Published on 2020-08-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] animal model animal models brain organoids cell line cell lines cellular Central nervous system CNS coronavirus coronavirus epidemic CoV COVID-19 development Effect effort expand experimental model experimental models ferrets generate hamsters infection rate information inoculated knowledge mechanism mechanisms MERS-CoV mice Model mouse hepatitis virus multiple sclerosis nervous Neurodegenerative disease patients Reinfection Research respond SARS-CoV SARS-CoV-2 System the disease the SARS-CoV-2 Therapeutic approach virus [DOI] 10.3389/fimmu.2020.02163 PMC 바로가기 [Article Type] Immunology
The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapiesIM-Point of view Published on 2020-05-192022-10-30 Journal: Internal and Emergency Medicine [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” ACE-2 ACE-inhibitors angiotensin II receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor ARB ARBs benefit binding blocker cardiovascular comorbidity cardiovascular disease cardiovascular diseases Cell cell types characterized China chromosome claimed Clinical course Clinical practice coding COVID-19 Deceased diabete disease Disseminated intravascular coagulation downregulation drugs Effect Effects Endothelial cell endothelial cells Endothelium enzyme epidemiological situation Evidence experimental model expressed expression female patient hazard host’s cell humans hypertension implication in vivo Infection intestinal involved Italian kidney molecular Mortality most prevalent comorbidity mRNA Neutral Occurrence Older Patient patients treated patients with COVID-19 Prospective Study protein level question Randomized receptor renal reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2-infected patients smoking Spike protein subsequent targets therapy Thromboembolism thrombosis tissues TMPRSS2 protease treated Treatment Vasculitis worse prognosis [DOI] 10.1007/s11739-020-02364-6 PMC 바로가기 [Article Type] IM-Point of view
Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19Review Published on 2020-05-062022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] activity acute respiratory syndrome affected antioxidant articles caused China Clinical management Clinical studies clinically Complication Controlled clinical trial coronavirus COVID-19 disease Effect effective experimental model expression homeostasis IL-1β IL-6 Inflammation Inflammatory diseases Keap1/Nrf2/ARE pathway management mechanism of action modulation molecular mechanism NF-κB Nrf2 organ organ damage outbreak oxidative stress ozone therapy 1 pathway peer-reviewed physiological Potential Research SARS-CoV-2 shown Support systemic therapy tissue damage viral infection viral infections [DOI] 10.3390/antiox9050389 PMC 바로가기 [Article Type] Review