Exploration of the Experience of Care Home Managers of COVID-19 Vaccination Programme Implementation and Uptake by Residents and Staff in Care Homes in Northern IrelandArticle Published on 2021-10-102022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] affected analysed Analysis approach Care care homes COVID-19 COVID-19 vaccination programme COVID-19 vaccine cross-sectional survey described eight experience exploration exploratory Factor handling highlight home implementation indicated Ireland managers media pandemic promote Quantitative resident residents response Side effects staff uptake vaccination Vaccine Vaccine uptake was used [DOI] 10.3390/vaccines9101160 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Neutralizing Antibody Levels Post COVID-19 Vaccination Based on ELISA Method—A Small Real-World Sample ExplorationArticle Published on 2021-10-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome antibody average BMI calculated Characteristics CoronaVac coronavirus coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine detection rate ELISA enzyme-linked immunosorbent assay exploration Follow-up group immunization inactivated investigated Level men Multivariate analysis neutralizing antibody neutralizing antibody detection no significant difference participant Participants positive positive rate provide recruited Sample SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccine significant difference stratified tested vaccination Vaccine women [DOI] 10.3390/vaccines9101139 PMC 바로가기 [Article Type] Article
Upregulation of Human Endogenous Retroviruses in Bronchoalveolar Lavage Fluid of COVID-19 PatientsCOVID-19 환자의 기관지폐포 세척액에서 인간 내인성 레트로바이러스의 상향 조절Research Article Published on 2021-10-062022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] activated addition age analyzed BALF bronchial cell bronchial cells bronchial epithelial cell Bronchoalveolar lavage fluid Cancer cellular senescence changes in characterized China conditions controls Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity Disease progression disease severity dysregulated dysregulation element endogenous endogenous retroviruses epithelial cells examined explain exploration expression Families global pandemic groups HBEC HBECs healthy control healthy controls HERV HERVs Human human bronchial epithelial cells human endogenous retrovirus human endogenous retroviruses identify immune senescence increase in increasing age Infection Inflammation Inflammatory inflammatory pathway Inflammatory response Inflammatory responses Intensive lavage Local lung Lungs mechanism monocyte Monocytes Mortality Older age oncogene outcomes pathophysiological Patient PBMC PBMCs Peripheral blood peripheral blood monocytes Pneumonia populations Potential biomarker potential biomarkers potential therapeutic target provide recognize retroviral retrovirus risk factor SARS-CoV-2 senescent severe COVID-19 Severe COVID-19 pneumonia shown Transcriptome transcriptomes upregulated upregulation [DOI] 10.1128/Spectrum.01260-21 PMC 바로가기 [Article Type] Research Article
The impact of COVID-19 first wave national lockdowns on perinatal outcomes: a rapid review and meta-analysisCOVID-19 First Wave National Lockdown이 주 산기 결과에 미치는 영향 : 빠른 검토 및 메타 분석Review Published on 2021-10-062022-09-01 Journal: BMC Pregnancy and Childbirth [Category] MERS, SARS, 진단, [키워드] 95% CI adjusted relative risk articles association Birth weight cause change changes in childhood China Cohort studies CORD country COVID-19 criteria Cross-sectional studies decrease Denmark English evaluate examined exploration First wave group incidence inclusion criteria increase increase in India Ireland Italy LBW lead lockdown lockdowns Low birth weight measure medRxiv Meta-analysis Mortality National Nepal Netherlands Not low Odds ratio Odds ratios outcome outcomes Perinatal pregnant women Preterm birth Prevalence promote provide PTB public health measures ranged rate ratio recent reduction Relative risk reported Research Result risk Saudi Arabia screened searched selected severity Sociodemographic Spain statistically significant Stillbirth stillbirth rates supplementary material total sample size Viral Viral transmission Virus Disease WHO Zimbabwe [DOI] 10.1186/s12884-021-04156-y PMC 바로가기 [Article Type] Review
A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters메틸트랜스퍼라제-결함 수포성 구내염 바이러스 기반 SARS-CoV-2 백신 후보는 햄스터의 SARS-CoV-2 감염에 대한 완전한 보호를 제공합니다Article Published on 2021-09-272022-09-11 Journal: Journal of Virology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition approved candidate Candidates caused Cell culture convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-protection cytokine Cytokine storm domain effective exploration expressed expressing full-length full-length S golden hamsters hamster hamsters Health immune responses immunized Immunocompromised induce innate immune lung Lung pathology mammalian cell mammalian cells methyltransferase mice mRNA mRNA cap methyltransferase mRNA stability NAb NAbs nasal nasal turbinate Neutralizing antibodies pandemic protection Protein protein translation RBD Receptor-binding domain Recovered COVID-19 patients respiratory S protein Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 S protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific neutralizing antibodies SARS-CoV-2-specific neutralizing antibody Serum level serum levels severe acute respiratory syndrome Coronavirus specific neutralizing antibodies storage Strains Syrian golden hamster Syrian Golden hamsters T-cell immune response Th1-biased immune response Th1-biased immune responses the RBD tissues triggered Vaccine vaccine candidate vaccine candidates Vaccines variant vectored vaccine vesicular vesicular stomatitis vesicular stomatitis virus Viral virus viruses VSV [DOI] 10.1128/JVI.00592-21 PMC 바로가기 [Article Type] Article
Social Quarantine and Its Four Modes: Conceptional Exploration and the Theoretical Construction of the Policies Against COVID-19Public Health Published on 2021-09-232022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] addition administration Against Analysis approach behavioural building Community complex construction COVID-19 COVID-19 pandemic Effects evaluate exploration feature global health Health identify lockdown measure Measures National pandemic Perspective Policy Psychological public health quarantine social contact social distancing Social policy social quarantine [DOI] 10.3389/fpubh.2021.614476 PMC 바로가기 [Article Type] Public Health
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice마우스에서 SARS-CoV-2 발병에 대한 렘데시비르의 경구 뉴클레오시드 유사체의 치료 효능Article Published on 2021-09-172022-09-11 Journal: bioRxiv [Category] 비임상, [키워드] administration Antiviral antiviral activity antivirals Breakthrough infection breakthrough infections breath conserved COVID-19 COVID-19 pandemic Culture develop dose-dependent drug effective Efficacy exhibited exploration GS-441524 human clinical trial humans IMPROVE in vitro in vivo increasingly infected with SARS-CoV-2 Infection lung cell lung cell line lung cell lines Lung pathology mice molnupiravir monoclonal antibodies monoclonal antibody nucleoside oral administration outcome outpatients parental pharmacokinetic Pulmonary function reduced Remdesivir RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants significantly Support target therapeutic therapeutic efficacy therapy These data translated Treatment uncontrolled vaccination Viral load Viral protein Viral proteins waning immunity [DOI] 10.1101/2021.09.13.460111 PMC 바로가기 [Article Type] Article
On Deep Landscape Exploration of COVID-19 Patients Cells and Severity MarkersCOVID-19 환자 세포 및 심각도 마커에 대한 심층적 조사Immunology Published on 2021-09-162022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] Analysis analyzed Biomarker Bronchoalveolar lavage fluid Cell cell heterogeneity cell population clinical response clinical responses contribute correlated COVID-19 COVID-19 symptom criterion Critical deep develop disease disease severities disease severity effective Effects epithelial exploration expression Factor healthy controls heterogeneous heterogeneous population high accuracy Immune cell immune cells immune landscape immune memory immune response immune system landscape lung machine-learning mechanism microenvironment moderate nine pathway Pathways Patient patients patients with COVID-19 patients with moderate pro-inflammatory response Prognosis promote regulate Regulatory required researcher response responses RNAseq second Severe patient severe patients severity single-cell single-cell analysis Spectrum the disease the patient Therapeutic strategies transcriptional Viral viral clearance [DOI] 10.3389/fimmu.2021.705646 PMC 바로가기 [Article Type] Immunology
COVID-19 Seroprevalence and Active Infection in an Asymptomatic PopulationMedicine Published on 2021-09-132022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] addition affected Airman antibodies approach assessment Asymptomatic average base comparable COVID-19 COVID-19 pandemic Department detect ELISA evaluated exploration force gold standard Human individual infection rate lateral flow Local multiple testing National Pandemics performance Population Rapid test researcher response RT-LAMP RT-PCR Saliva SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection seroprevalance Seroprevalence System tested Testing Viral RNA Wing [DOI] 10.3389/fmed.2021.749732 PMC 바로가기 [Article Type] Medicine
Exploration of potential risk factors for COVID-19 severity in patients participating in oncology clinical trials종양학 임상 시험에 참여하는 환자의 COVID-19 중증도에 대한 잠재적 위험 요인 탐색Editorial Published on 2021-09-012022-09-11 Journal: Respiratory medicine [Category] 임상, [키워드] clinical trial COVID-19 severity exploration Factor oncology Patient potential risk [DOI] 10.1016/j.rmed.2021.106535 PMC 바로가기 [Article Type] Editorial