Editorial: Time to explore the missing links: from activated platelets and platelet extracellular vesicles in SARS-CoV-2 infection, through heterogeneity in the host physiological, immuno-inflammatory and haemostatic responses to mRNA-based vaccine or infection induced polyclonal neutralizing antibodies and passive immunity편집자: 누락된 연결을 탐색할 시간: SARS-CoV-2 감염의 활성화된 혈소판 및 혈소판 세포외 소포에서 숙주의 이질성을 통해 mRNA 기반 백신 또는 감염 유도 다클론 중화 항체 및 수동적 생리학적, 면역염증 및 지혈 반응에 대한 반응 면역Editorial Published on 2022-06-012022-09-12 Journal: Transfusion and apheresis science : official journ [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated extracellular vesicle heterogeneity Host immuno-inflammatory Infection mRNA-based vaccine neutralizing antibody passive immunity physiological Platelet polyclonal response SARS-COV-2 infection time [DOI] 10.1016/j.transci.2022.103464 PMC 바로가기 [Article Type] Editorial
SARS-CoV-2 and Mitochondrial Proteins in Neural-Derived Exosomes of COVID-19코로나19 신경 유래 엑소좀의 SARS-CoV-2 및 미토콘드리아 단백질Article Published on 2022-06-012022-09-11 Journal: Annals of neurology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료법, [키워드] 12S rRNA acute COVID-19 anion ANN Astrocyte Biomarker Biomarkers calcium calcium channel CD81 Cell Central nervous system Complex I complex III controls COVID-19 Exosome extracellular vesicle Extracellular vesicles Frame healthy controls Human Humanin LETM1 leucine long-COVID manifestation marker MCU mechanism Mitochondria mitochondrial N-methyl-D-aspartate N-methyl-D-aspartate receptor Neuropsychiatric nucleocapsid PASC plasma Protein quantified resolved respiratory chain S1 protein SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 S1 significantly sodium subunit therapeutic therapeutic trials transmembrane trials VDAC1 was used [DOI] 10.1002/ana.26350 PMC 바로가기 [Article Type] Article
Platelet and extracellular vesicles in COVID-19 infection and its vaccinesReview article Published on 2022-06-012022-10-05 Journal: Transfusion and apheresis science : official journ [Category] COVID19(2023년), SARS, 바이오마커, [키워드] activated adenovirus-based bidirectional Cell characterized COVID-19 COVID-19 infection extracellular vesicle Extracellular vesicles granular immune system Inflammation Interaction microparticles neutrophil parent cell Pathways Platelet Platelets prognostic SARS-CoV-2 SARS-COV-2 infection therapeutic thrombosis Vaccine viral infection virion VITT [DOI] 10.1016/j.transci.2022.103459 [Article Type] Review article
Extracellular vesicles in kidney disease Reviews Published on 2022-05-312022-10-05 Journal: Nature reviews. Nephrology [Category] 바이오마커, [키워드] addition administration Alter amplification body fluids candidate Cell cell type cell-to-cell communication chronic kidney diseases circulating diagnostic Efficacy Evidence extracellular vesicle fibrosis gene expression profile glomerular Increasing Inflammation investigated involved kidney kidney damage Kidney disease majority mechanism modulate molecular organ pathology pathophysiological preclinical data prognostic promote reduce reflect regenerative released robust Standardization stem cell target cells thought tubular cell urinary Vesicle [DOI] 10.1038/s41581-022-00586-9 [Article Type] Reviews
Pivoting Novel Exosome-Based Technologies for the Detection of SARS-CoV-2SARS-CoV-2 검출을 위한 새로운 엑소좀 기반 기술 활용Review Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acceleration Accessibility Accuracy approach approaches biochemical Biomarker cell-to-cell communication commercialization COVID-19 Critical detection diagnosis of COVID-19 diagnostic diagnostics ENhance EVs Exosome Exosomes Extracellular extracellular vesicle Extracellular vesicles focus implementation infectious agents Isolation molecular NIH novel physical Radical RADx Rapid SARS-CoV-2 SARS-CoV-2 viral infection SARS-CoV-2 virus subpopulation surveillance testing technology Viral viral infection [DOI] 10.3390/v14051083 PMC 바로가기 [Article Type] Review
An intra-cytoplasmic route for SARS-CoV-2 transmission unveiled by Helium-ion microscopyArticle Published on 2022-03-082022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 치료제, [키워드] ACE2 alternative route angiotensin Cell Cell signalling connection docking docking mechanism event explain extracellular vesicle feature Host host cell immune infected cell Infection intracellular assembly membrane-bound Microscopy molecular performed released SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 transmission SARS-CoV-2 virion spike glycoprotein Surveillance Vero E6 cell Viral transmission virion [DOI] 10.1038/s41598-022-07867-0 PMC 바로가기 [Article Type] Article
Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccinationArticle Published on 2022-02-082022-10-04 Journal: NPJ Vaccines [Category] 바이오마커, [키워드] Activation adjuvants Adverse reaction Adverse reactions antibody production Antibody titers Biomarker BNT162b2 circulating conducted correlated COVID-19 COVID-19 vaccination Efficacy EVs Extracellular extracellular vesicle Fever immune responses less local pain lymphocyte microRNA miRNA mRNA-based vaccine Pain pandemic Proinflammatory cytokine prospective cohort study RNA vaccines second dose sera serum systemic adverse reaction systemic symptoms TNF-α Vaccine vaccine efficacy Vesicle [DOI] 10.1038/s41541-022-00439-3 PMC 바로가기 [Article Type] Article
AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory SyndromeAKR1B10, SARS-CoV2 중증 급성 호흡기 증후군에서 사이토카인 폭풍의 방아쇠 중 하나Article Published on 2022-02-082022-09-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] Activation Acute respiratory failure AKR1B10 Analysis biological plausibility cell types contribute COVID-19 cytokine Cytokine storm Cytokines died drug treatment enzyme experiment expression extracellular vesicle Extracellular vesicles Factor form gene encoding highlight hospitalised COVID-19 patient hospitalised COVID-19 patients Hypothesis identify IL-1β IL-6 increased expression induce Inflammation inhibitor interleukin interleukin-1β interleukin-6 involved lipopolysaccharides LPS lung lung cells Macrophage macrophages management measurement modulation Occurrence outcomes over-expression Patient pharmacological target Preventing pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines Protein reduced reducing Reductase respiratory Respiratory failure SARS-CoV2 secreted sera severe forms of COVID-19 severity significantly storm systemic impact the cytokine storm the disease TNF α TNFα transcriptomic data transferred treated Trigger Tumor tumor necrosis tumor necrosis factor [DOI] 10.3390/ijms23031911 PMC 바로가기 [Article Type] Article
Strong SARS-CoV-2 N-Specific CD8 + T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice강력한 SARS-COV-2 N- 특이 적 CD8 + T 면역에 의해 유도 된 세포 외 소포에 의해 유도 된 면역은 마우스에서 치명적인 감염으로부터 보호됩니다.Article Published on 2022-02-062022-09-10 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] airways anti-SARS-CoV-2 vaccine antibody waning Antigen Associate Bronchoalveolar lavage fluid CD8 CD8+ T cell immunity cells characterized Combination described distribution DNA dose Efficacy Efficiency Evidence EVs expected expressing extracellular vesicle Extracellular vesicles fused highest idea immune memory immune response Immunity immunization immunized mice induce induced injection Intramuscular injection lethal lethal doses limitation Localization long-lasting lung Lungs Lymphocytes memory cell mice N-terminus Nef percentage platform prophylactic strategy protection Protein remained SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection spleen Strong T cell T cells T lymphocyte T lymphocytes target tissue Vaccines variants vector vectors Viral viral variant Viral variants were infected [DOI] 10.3390/v14020329 PMC 바로가기 [Article Type] Article
Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, including Platelet Factor 4, High-Mobility Group Box 1 Protein and HistonesArticle Published on 2022-02-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] activated Adsorbent Adsorption binding Box Complication coronavirus disease COVID-19 deplete deregulated disease severity disorders driven by effector event Evidence expressing extracellular vesicle Extracellular vesicles Factor group heparin histone Histones HMGB1 immunothrombosis increased mortality marker multiorgan failure NETs Neutrophil extracellular trap Neutrophil extracellular traps Pathogens PF4 Platelet platelet factor 4 Platelets Protein Sepsis thrombosis thrombotic complication [DOI] 10.3390/ijms23031823 PMC 바로가기 [Article Type] Article