fibroblasts – Page 4 – Communicable Diseases Research

Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis

Review

Published on 2020-10-142022-10-30
Journal: Molecular Medicine [Category] Coronavirus, MERS, SARS,

Structural Variants Create New Topological-Associated Domains and Ectopic Retinal Enhancer-Gene Contact in Dominant Retinitis Pigmentosa

구조적 변이체는 우성 색소성 망막염에서 새로운 위상 관련 도메인 및 이소성 망막 인핸서-유전자 접촉을 생성합니다

Article

Published on 2020-10-052022-08-07
Journal: American Journal of Human Genetics [Category] 유전자 메커니즘,

[키워드] adRP affected Altered binding site blindness breakpoint Cell characterized Chr17q22 complex Contact Control creation differential expression disease domain dominant dominant retinitis pigmentosa ectopic ectopic expression enhancer enhancers Epigenetic Families fibroblast fibroblasts Gain of function GDPD GDPD1 Genome sequencing genomic genomic region genotyping Hi-C highlight increased expression individual individuals investigated leads LINC01476 locus loss of vision mechanism Mendelian diseases modeling Molecular diagnosis New photoreceptor photoreceptor precursors cells pluripotent stem cell PPCs precursor qPCR resulting Retinal retinal enhancer retinal expression retinal organoid retinal organoids retinal-specific enhancer Retinitis retinitis pigmentosa RNA RP17 stem cells Structural variant structural variants SVs topologically associated domains transcription factors vision was performed whole-genome sequencing YPEL2
[DOI] 10.1016/j.ajhg.2020.09.002 PMC 바로가기 [Article Type] Article

Cells of the adult human heart

Article

Published on 2020-09-242022-10-04
Journal: Nature [Category] Fulltext, SARS, 유전자 메커니즘,

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation

포유류 Hbs1L 결핍은 Pelota 고갈 및 80S 모노솜 축적과 관련된 선천적 기형 및 발달 지연을 유발합니다

Research Article

Published on 2019-02-012022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 4EBP1 accompanied accumulation addition affecting aggregation Anomaly baseline biallelic mutation biallelic mutations binding cause caused Cell cells Characteristics characterized coding region conditions control mechanisms controls Critical deficiency demonstrated Depletion developmental delay downstream Effect Efficiency element expression facial fibroblast fibroblasts functional growth Hbs1L human cell human cells humans hypotonia implicated increase in inhibition involved knockdown lack lead Loss mechanism mice monosome mouse model mRNA mRNA level mTOR mTOR expression murine Mutation ortholog pathway Patient pelo phenotype phenotypic Phosphorylation polysome proteasomal proteasome Protein protein expression Quality control reduced Regulation reported rescued restored resulting ribosomal RNA ribosome ribosomes RNA RT-PCR Sequencing Support the patient These data tissues transcript translation translational upregulation utilization western blot Western blot analyses Western blot analysis yeast
[DOI] 10.1371/journal.pgen.1007917 PMC 바로가기 [Article Type] Research Article

Surface-assembled poly(I:C) on PEGylated PLGA microspheres as vaccine adjuvant: APC activation and bystander cell stimulation

PEG화된 PLGA 미세구슬 위에 표면 조립된 poly(I:C) 백신 보조제: APC 활성화 및 주변 세포 자극

Article

Published on 2016-11-302024-08-18
Journal: International Journal of Pharmaceutics [Category] 파상풍,

[키워드] adjuvants dendritic cells fibroblasts immunostimulants Microspheres poly(I:C) vaccine formulation

Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation

Review

Published on 2016-11-082023-08-30
Journal: Frontiers in Immunology [Category] E형 간염,

[키워드] beta2 heterotrimer chemokines fibroblasts lymphotoxin alpha1 Tertiary lymphoid structures tumor necrosis factor-alpha
[DOI] 10.3389/fimmu.2016.00477 PMC 바로가기 [Article Type] Review

Skin and arthropods: an effective interaction used by pathogens in vector-borne diseases

article

Published on 2015-04-302024-09-01
Journal: European Journal of Dermatology [Category] 말라리아,

[키워드] arthropod saliva dendritic cell fibroblasts keratinocytes Leishmaniasis Lyme borreliosis vector-borne diseases
[Article Type] article

Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence

p53 및 Rb의 조절은 대체 NF-κB 경로를 EZH2 발현 및 세포 노화에 연결합니다

Research Article

Published on 2014-09-252022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated Activation alternative NF-κB pathway Analysis ANAPC1 c-Rel cancer cell Cancer cells CD40 CD40 ligand CD40L CDK4 CDK6 Cell cell cycle cell senescence cellular senescence ChIP chromatin immunoprecipitation chronic chronic lymphocytic leukemia classical complexes Crosstalk de-repression defined Degradation DEK dependent on Effect effector effectors expression EZH2 fibroblasts Hematological malignancies Hematological malignancy IKK IKKα induce inhibit investigated IκB IκBα knockdown leads Loss Lymphocytic leukemia mechanism microarray analysis microenvironment NEMO NF-κB NF-κB inducing kinase NF-κB pathway NF-κB2 NIK or canonical oxygen p100 p21WAF1 p52 p53 pathway patients phenotype Phosphorylation polycomb protein promote protein stability provide PSMA5 quantitative PCR RacGAP1 reactive oxygen species reactive oxygen specy regulate Regulation regulatory subunit RELA RelB repression retinoblastoma retinoblastoma protein ROS SASP senescence senescent siRNA solid tumors stability stimulated subset subunit subunits suppress suppression target gene Target genes the cell Tumor tumor suppressor tumorigenesis tumors tumour suppressor turn western blot Western blot analyses Western blot analysis wild type
[DOI] 10.1371/journal.pgen.1004642 PMC 바로가기 [Article Type] Research Article

Cell Type-Specific Functions of Period Genes Revealed by Novel Adipocyte and Hepatocyte Circadian Clock Models

새로운 지방세포 및 간세포 일주기 시계 모델에 의해 밝혀진 기간 유전자의 세포 유형별 기능

Research Article

Published on 2014-04-032022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] adipocytes Affect amplitude animals Behavior biochemical Bmal1 Brain Cell cell types cellular circadian clock circadian rhythms CLOCK component Cry1 Cry2 Effect evaluated expected Families feasible fibroblasts function Gene Expression Genes Genetic genomic hepatocyte hepatocytes hypothalamus Impact implication Interaction kinetic knockdown knockout mice lentivirus library Local Luminescence mechanism metabolism microplate reader Model molecular negative feedback negative feedback mechanism neurons novel nuclei Per1 Per2 PER3 Period phenotype Physiology Previous studies regulated reporter reveal Revealed RNA RNA interference small molecule Small molecules tissue specific transcriptional
[DOI] 10.1371/journal.pgen.1004244 PMC 바로가기 [Article Type] Research Article

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다

Research Article

Published on 2013-02-142022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction
[DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article