Rational design of flavonoid based potential inhibitors targeting SARS-CoV 3CL protease for the treatment of COVID-19Research article Published on 2021-08-012022-10-05 Journal: Journal of Molecular Structure [Category] 신약개발, 치료법, 치료제, [키워드] 3CL 3CL Protease antiviral drug binding affinity candidate Compound COVID-19 death develop docking drug-likeness examined flavonoid In-vitro Infection inhibitor lack Ligand means molecular docking oral bioavailability outbreak pandemic pharmacokinetic prevention of COVID-19 protease reported SARS-CoV SARS-CoV-2 Toxicity transmission rate Treatment Vaccinations was used [DOI] 10.1016/j.molstruc.2021.130380 [Article Type] Research article
Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 M PRO4.8K 플라보노이드의 포괄적 인 가상 스크리닝Article Published on 2021-07-292022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 치료제, [키워드] absence active site affected Analysis antiviral activity AutoDock AutoDock vina Comprehensive Computational biology and bioinformatics Coronaviruses criteria curated database docking Drug discovery flavonoid flavonoids hinge movement in silico inactive inhibit inhibition assay Inhibition assays inhibitors Interpretation lack limitation mechanism molecular molecular dynamics mutant Pathways plasticity protease reason reported reveal robust SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease structural biology triggered Usage Virtual screening [DOI] 10.1038/s41598-021-94951-6 PMC 바로가기 [Article Type] Article
Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin InhibitorsMicrobiology Published on 2021-07-082022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome blocked buffer Cell cell viability assay classical conserved contribute coronavirus E protein Effect effective envelope envelope protein epigallocatechin expressed expression Extracellular family Coronaviridae flavonoid genus Betacoronavirus HEK293 cell inflammasome activation inhibited inhibition inhibitor inhibitors inhibitory activity introduced involved ion channel inhibitors kDa membrane protein novel antiviral drug patch-clamp electrophysiology plasma membrane proliferation Protein quercetin RNA virus SARS CoV SARS CoV-1 SARS-CoV SARS-CoV E SARS-CoV-2 sequence signal peptide single-stranded positive-sense suppress tested transfer transmembrane viability viroporins virus Virus life cycle [DOI] 10.3389/fmicb.2021.692423 PMC 바로가기 [Article Type] Microbiology
Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic ReviewSARS-CoV-2 감염에 대한 유망한 항바이러스제로서의 플라보노이드: 기계론적 검토Review Published on 2021-06-252022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] activity acute respiratory syndrome affected agent Antiviral antiviral activity antiviral properties antiviral property baicalin benefit biological activities clinical manifestation clinical manifestations complications Compound coronavirus COVID-19 COVID-19 disease COVID-19 infection Cytokines derivatives diagnosed disease Ebola Effect effective FIVE flavonoid flavonoids hesperidin HIV host response host responses Human immunodeficiency virus immunodeficiency virus indirect effect indirect effects infective Inflammation inflammatory pathway Influenza inhibit interferons kinases lung MERS Middle East Middle East respiratory syndrome modulate mRNA N-terminal nuclear oxidative damage pharmacological treatments polyphenol pro-inflammatory cytokines protease provide quercetin Regulation respiratory review RNA polymerase RNA virus SARS-CoV-2 Severe acute respiratory syndrome shown Stage subsequent syndrome these compound these compounds Treatment Viral viral infection virus virus replication viruses [DOI] 10.3390/molecules26133900 PMC 바로가기 [Article Type] Review
Food Containing Bioactive Flavonoids and Other Phenolic or Sulfur Phytochemicals With Antiviral Effect: Can We Design a Promising Diet Against COVID-19?Nutrition Published on 2021-06-172022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] activity Against alleviate anti-inflammatory action Antiviral approved Bioavailability Can complementary Containing contributing to coronavirus coronavirus disease country COVID-19 diet distribution drug flavanone flavonoid flavonol food Functional foods global pandemic Health Infectious disease information knowledge Laboratory mechanism molecular monoclonal antibodies Novel coronavirus Other pathogen Perspective phytochemical phytochemicals plant Prevent Research researcher SARS-CoV-2 Secondary Metabolite Spread sulfur Therapeutic approach therapeutic approaches therapy these compounds Vaccine viral infection viral pathology while [DOI] 10.3389/fnut.2021.661331 PMC 바로가기 [Article Type] Nutrition
Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral AgentsReview Published on 2021-06-072022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acute respiratory syndrome Administered agent Anti-inflammatory antioxidant Antiviral antiviral property antivirals biological activity candidate caused cellular coronavirus coronavirus disease CoV COVID-19 COVID-19 pandemic creating drugs effective flavonoid flavonoids functions Glycosyl glycosyl flavonoids glycosylated flavonoids management modulate Pandemics Potential protease 3CLpro protective vaccine Research researcher SARS-CoV-2 spike glycoprotein Spread therapeutic agent Toxicity Treatment widespread [DOI] 10.3390/ph14060546 PMC 바로가기 [Article Type] Review
The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection엔돌리소좀 2-기공 채널 억제제로서의 나린제닌의 발견과 SARS-CoV-2 감염에서의 새로운 역할Review Published on 2021-05-072022-09-11 Journal: Cells [Category] SARS, 신약개발, 치료제, [키워드] blocker channel coronavirus Coronavirus infection COVID-19 Diseases effective flavonoid flavonoids impairing mammalian endolysosome mechanism naringenin pandemic pharmacological plague plant vacuole progression rationale role SARS-CoV-2 shown solid tumor TPC channels Tumor [DOI] 10.3390/cells10051130 PMC 바로가기 [Article Type] Review
Deep learning model for virtual screening of novel 3C-like protease enzyme inhibitors against SARS coronavirus diseasesSARS 코로나바이러스 질병에 대한 새로운 3C 유사 프로테아제 효소 억제제의 가상 스크리닝을 위한 딥 러닝 모델Article Published on 2021-05-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료제, [키워드] 3CLpro Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus applied can be used CNN CNN Model Compound compounds Convolutional neural network coronavirus COVID-19 COVID-19 pandemic Decision tree deep deep learning deep learning-based method disease enzyme FDA-approved drug FDA-approved drugs FIVE flavonoid inhibitor inhibitory activity input Naïve Bayes phytochemical phytochemical compounds Precision predict protease random Random forest recall resulting ROC SARS Coronavirus SARS-CoV screened sensitivity severe acute respiratory syndrome Coronavirus specificity Support support vector machine Virtual screening Zinc [DOI] 10.1016/j.compbiomed.2021.104317 PMC 바로가기 [Article Type] Article
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA PolymeraseArticle Published on 2021-04-222022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] antiviral activity antiviral agent Antiviral agents antiviral therapy baicalein baicalin binding biochemical caused Compound coronavirus coronavirus 2 COVID-19 exhibited flavonoid global pandemic In vitro studies infected individual Infectious disease inhibit inhibitor Nsp12 pathogen polymerase RdRP Remdesivir respiratory RNA-dependent RNA polymerase SARS-CoV-2 selective the SARS-CoV-2 therapeutic transmitted treat Treatment [DOI] 10.3390/microorganisms9050893 PMC 바로가기 [Article Type] Article
Perspectives on plant flavonoid quercetin-based drugs for novel SARS-CoV-2Review Published on 2021-03-242022-10-28 Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19, [키워드] 3CL pro 3CLpro 3D structure Abstract Ala Antiviral antiviral activities antiviral activity antiviral property binding energy caused Combination complex COVID-19 derivative deubiquitinase docked docking drug drug candidate drug design enzyme Enzymes flavonoid inhibiting interactions involved miRNA Mol molecular mechanism N-terminus Novel coronavirus pandemic Papain-like protease pathway Phytomedicine predicted proof Protein provided quercetin Regulation residue RNA RNA binding protein RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 main protease shown spike glycoprotein Treatment viral pathogenesis Virtual screening viruses Zinc [DOI] 10.1186/s43088-021-00107-w PMC 바로가기 [Article Type] Review