A Multistate Toggle Switch Defines Fungal Cell Fates and Is Regulated by Synergistic Genetic Cues다중 상태 토글 스위치는 곰팡이 세포의 운명을 정의하고 시너지 유전 신호에 의해 조절됩니다Research Article Published on 2016-10-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompany Analysis antagonistic can be used Candida tropicalis Cell cell differentiation cell fate cell type cell types cellular change chromatin Combination determined by ectopic ectopic expression Epigenetic event exhibit expression Fate Formation fungal fungi Gene Expression Gene expression profiles Genetic genetic analysis genetic regulation growth rates higher eukaryotes hybrid increase induce instances lack less master regulator multicellular organism multicellular organisms occurred opposite pathogen phenotypic Regulation stability stable cell stem cell switch switching synergistic to define transcription factor transcription factors transcriptional transcriptionally underlie unique Wor1 yeast [DOI] 10.1371/journal.pgen.1006353 PMC 바로가기 [Article Type] Research Article
Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and FunctionSUN1 결핍 마우스의 감수분열 분석은 포유류 감수분열 LINC 복합체 형성 및 기능에서 SUN2의 뚜렷한 역할을 보여줍니다Research Article Published on 2014-02-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence appear attachment cause chromosome Clusters complexes component composed conserved Critical Deficient demonstrated described detect determine domain driving error event expressed Formation function functional functions Genome homolog indicate infertility interfere KASH5 lead meiosis meiotic meiotic recombination membrane mice nuclear nuclear envelope prophase Protein protein complex protein complexes Proteins provoke recent Recombination regulated retained role shown subsequent SUN1 SUN2 telomere telomeres while [DOI] 10.1371/journal.pgen.1004099 PMC 바로가기 [Article Type] Research Article
Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia FormationResearch Article Published on 2013-10-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cell activate Affect antibody bats Betacoronavirus blocked cathepsin L cathepsin L-dependent Cell cell type Cl cleave cleaved co-expressed coronavirus coronavirus spike glycoprotein determined elicit endosome Eptesicus experiment Express Extracellular fluids Formation function glycoprotein host cell host protease host range Human immunoblot inhibitor lentivirus maturation membrane fusion MERS MERS-CoV MERS-CoV S protein MHV Middle East murine Neutral Neutralizing antibodies New World non-infectious plasma membrane polyclonal produced producing pseudotype pseudovirion pseudovirus entry reagent receptor released Research respiratory role S protein S2 domain serine protease Spike protein Syncytia syncytia formation the S protein the Spike tissue Treatment triggered trypsin variety VERO E6 cells viral spike virus virus entry [DOI] 10.1371/journal.pone.0076469 PMC 바로가기 [Article Type] Research Article