Investigation of compatibility of severe acute respiratory syndrome coronavirus 2 reverse transcriptase-PCR kits containing different gene targets during coronavirus disease 2019 pandemicResearch Article Published on 2020-08-262022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] acute respiratory syndrome added amplification amplification curve analyses Biomarker coronavirus coronavirus disease correlation COVID-19 Diagnosis diagnosis of SARS-CoV-2 evaluated gene target Genes high correlation investigation material pandemic Patient PCR RdRp gene regression analysis RT-PCR Sample SARS-CoV-2 SARS-CoV-2 RT-PCR single gene tested while [DOI] 10.2217/fvl-2020-0169 PMC 바로가기 [Article Type] Research Article
Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory ResponseArticle Published on 2020-07-072022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] activated Activation acute inflammatory response acute respiratory syndrome Analysis Antiviral antiviral response bioinformatics Biomarkers bronchial bronchial epithelial bronchial epithelial cell category caused Cell cell death cells Community coronavirus Course COVID-19 differentially expressed disease expressed gene expression functional functional annotation gene expressions gene target hallmark highlight host cells host response Ifi44 IFI44L IFIT1 IFIT2 IFIT3 IFITM1 IFN IFN response IgG immune response Immunoglobulin in vitro induction Infection innate response interferon Interferon lambda investigated involved IPA IRF9 landscape lncRNA lncRNAs Long long noncoding RNA lung tissue MAPK MX1 Necrosis network analysis NHBE OAS2 OAS3 Ontology pathogenesis of COVID-19 pathogenic Pathway analysis Patient Replication Research response RNA role SARS-CoV-2 SARS-COV-2 infection spread of COVID-19 suppressed tissue TNF Transcriptome upregulated upstream viral infection Viral protein with COVID-19 [DOI] 10.3390/genes11070760 PMC 바로가기 [Article Type] Article
Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltrationResearch Article Published on 2020-06-302023-08-28 Journal: Breast Cancer Research : BCR [Category] E형 간염, [키워드] Biomarker Breast cancer Co-expression analysis gene target Interaction networks miRNA families TNBC Tumor grade Tumor interstitial fluid Tumor-infiltrating lymphocytes [DOI] 10.1186/s13058-020-01295-6 PMC 바로가기 [Article Type] Research Article
Evaluating the use of posterior oropharyngeal saliva in a point-of-care assay for the detection of SARS-CoV-2Research Article Published on 2020-06-142022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] automated collected Community Coronavirus disease 2019 COVID-19 COVID-19 patient detection rate E gene Evaluating gene target Logistic median molecular Nasopharyngeal swab NPs Oropharyngeal pandemic patients point-of-care point-of-care testing positive problem Saliva saliva specimen SARS-CoV-2 SARS-CoV-2 detection significant difference significantly specimen tested the SARS-CoV-2 [DOI] 10.1080/22221751.2020.1775133 PMC 바로가기 [Article Type] Research Article
Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancyOct1/Pou2f1은 결장 재생에 선택적으로 필요하며 결장 악성 종양을 조절합니다.Research Article Published on 2019-05-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele blocked Cancer Cell Characteristics ChIPseq Colon Colon cancer colon carcinoma Colorectal Colorectal cancer damage death deleted Deletion determine dextran diagnosed differentially expressed differentially expressed gene Differentially expressed genes disease driven by Effect etiology expressed Factor gastrointestinal tract Gene Expression gene target Gut gut stem cell homeostasis identify in vitro in vivo incidence intestinal stem cell Intestinal stem cells maintain maintenance malignancy mechanism metabolism mitotic Mortality Organoid organoids outcome outcomes overlap passage pathophysiology Patient Physiology Pou2f1 preserved proceed promote protein level regulate required significantly sodium sodium sulfate stability stem cell stem cells Stress stress response sulfate Suppressor gene target gene Target genes targets The United States transcription factor Treatment Tumor tumor suppressor tumor suppressor gene United States [DOI] 10.1371/journal.pgen.1007687 PMC 바로가기 [Article Type] Research Article
Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania심각한 말라리아 및 탄자니아 북동부의 선택적 압력과 관련된 새로운 유전적 다형성Research Article Published on 2018-01-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition African allele frequencies allele frequency analyses approach association caused Cell characterisation chromosome chromosome 4 Cohort country dataset Endemic Evidence evidence of expected extended haplotype Factors Frequency GCLC gene mutation gene target Genetic genetic factors genetic mutation genetic mutations Genetic polymorphism Genome Genome-wide association studies Genome-wide association study genomes genotyping GWAS haplotypes HbS High-resolution histocompatibility Host Human genome human population human populations identification identify immunological pathways imputation independent Intervention joint KLHL3 linkage loci Major major histocompatibility complex malaria malarial disease mechanism MHC molecular morbidity Mortality natural selection novel parasites performed Phenotypes phenotypic phenotypic variation Plasmodium falciparum Plasmodium falciparum infection polymorphism Population Positive selection Protective Protein Rare variants receptor reduced risk Region Research resulting risk factor selection pressure selective Sequencing severe malaria sickle cell sickle cell trait Significant significant effect SNPs Structural variant structural variants sub-Saharan Africa susceptibility susceptibility loci SYNJ2BP target variant Variation whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007172 PMC 바로가기 [Article Type] Research Article