Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study우려의 알파(B.1.1.7) 변종과 비교한 SARS-CoV-2 델타(B.1.617.2)에 대한 입원 및 응급 치료 출석 위험: 코호트 연구Comparative Study Published on 2022-01-012022-09-10 Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 변종, 치료기술, [키워드] adjust adjusted adjusted hazard ratio Admission age Alpha Alpha variant Analysis B.1.1.7 B.1.617.2 both groups Care Cohort cohort study Cox regression data set dataset death delta variant Department Deprivation Digital dominant Emergency Emergency Care England Ethnicity finding funding Generation greater health-care health-care service health-care services hospital Hospital admission immunisation Innovation International lead Lineage median age Medical Research Council Mortality Most patient Most patients National NHS outbreak outcomes Patient patients with COVID-19 Precision predominant Public Health England Relative risk residence Result risk SARS-CoV-2 delta SARS-CoV-2 variant second secondary Sequencing service severe disease severity Sex specimen Stratified Cox regression subgroups System Transmissibility Travel unvaccinated population unvaccinated populations vaccination Vaccination Status variant was done was used whole-genome sequencing [DOI] 10.1016/S1473-3099(21)00475-8 PMC 바로가기 [Article Type] Comparative Study
The Avon Longitudinal Study of Parents and Children – A resource for COVID-19 research: Home-based antibody testing results, October 2020. An emphasis on self-screening at a population levelData Note Published on 2021-12-022022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] ALSPAC Antibody test Antibody testing birth cohort study checked Children of the 90s Complete coronavirus COVID-19 COVID-19 pandemic dataset Generation Health longitudinal offspring online questionnaire parent participant pillar population level population-based cohort positive positive result Positive test pregnant women questionnaire questionnaire data random recruited released reported Research resource response Result Sociodemographic factor supported tested women [DOI] 10.12688/wellcomeopenres.16616.2 PMC 바로가기 [Article Type] Data Note
The Avon Longitudinal Study of Parents and Children – A resource for COVID-19 research: Questionnaire data capture November 2020 – March 2021Data Note Published on 2021-11-292022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] age ALSPAC birth cohort study Children of the 90s coronavirus coronavirus disease COVID COVID-19 COVID-19 cases dataset datasets employment Generation Health longitudinal mental health mother offered offspring online questionnaire pandemic parent participant Participants physical population-based cohort positive COVID-19 predicted pregnant women Public Health England questionnaire Questionnaires recruited released reported Research resource response returned Self-reported symptoms Sociodemographic supported women [DOI] 10.12688/wellcomeopenres.16950.2 PMC 바로가기 [Article Type] Data Note
COVID-19 Vaccine Hesitancy among the Younger Generation in JapanArticle Published on 2021-11-072022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] age Anxiety applied association children COVID-19 COVID-19 pandemic demonstrated economics effective Gender Generation Health status Hesitancy Hiroshima investigated Japan Japanese men Older reduce Regression regression models significantly significantly higher university vaccination Vaccine hesitancy women younger generation younger people [DOI] 10.3390/ijerph182111702 PMC 바로가기 [Article Type] Article
Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant고분자 글리코 보조제에 대한 접합을 통한 SARS-CoV-2 항원에 대한 강력한 세포 및 체액 면역 생성Article Published on 2021-11-012022-09-12 Journal: Biomaterials [Category] MERS, SARS, 진단, [키워드] activate activated adjuvant adjuvants amplified antibody Antigen antigen-presenting cell antigen-specific antibody APCS B cells caused CD4 CD8 cells cellular composed convalescent human serum COVID-19 COVID-19 vaccine Disease model effective elicit follicular generate Generation Glycopolymers Humoral immunity Humoral response IgGs immune response increase in long-lasting mice monomer Neutralizing Neutralizing titer platform Polymer-protein conjugates Polymeric glyco-adjuvant producing Protein protein antigen receptor robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 virus secreting shown Spread subunit Subunit vaccine Subunit vaccine formulation. T cell responses T cells the Spike the vaccine TLR7 Toll-like receptor triggering vaccination Vaccine vaccine candidate wild-type yielding [DOI] 10.1016/j.biomaterials.2021.121159 PMC 바로가기 [Article Type] Article
Who’s more vulnerable? A generational investigation of COVID-19 perceptions’ effect on Organisational citizenship Behaviours in the MENA region: job insecurity, burnout and job satisfaction as mediatorsResearch Published on 2021-10-272022-10-28 Journal: BMC Public Health [Category] COVID-19, MERS, SARS, [키워드] Analysis block Burnout country COVID-19 COVID-19 perception Effect equation Evidence Generation Generation X Generation Z Generational differences hypothesised Impact indirect effect Job insecurity Job satisfaction knowledge Mediation analysis MENA Middle East Multi-group analysis North offer Organisational citizenship behaviour (OCB) outcome pandemic Pandemics Partial Partial-least-square structural equation modelling predict Research Result Satisfaction square supplementary material was collected [DOI] 10.1186/s12889-021-11976-2 PMC 바로가기 [Article Type] Research
Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases기존 간 및 위장 질환의 SARS-CoV2 및 새로운 변이체에 대한 숙주 반응Review Published on 2021-10-252022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 치료기술, [키워드] accumulation ACE2 receptor Alpha Alter Altered B.1.1.28.1 B.1.1.7 B.1.351 Beta binding Brazil changes in characteristic CLARITY cleavage condition coronavirus COVID-19 cytokine Cytokine storm Definitive determinant diabetes disease Diseases disorder disorders distribution drastic E484K emerging variants expression feature finding First wave Gastrointestinal gastrointestinal disease Generation GI Tract Host Host immune response host protease host protease TMPRSS2 host response hypertension Immune escape Immune status immunocompromised condition immunomodulation implicated incidence India indicate Infection Inflammation L452R lack less liver liver failure Liver injury manifestation Manifestations mechanism Mild Mortality Mutation N501Y novel Novel coronavirus obesity occur organs outcome outcomes P681R pandemic Patient predominant Protein binding radiologic receptor Receptor binding Replication reported required response risk factor RNA SARS-CoV2 selection pressure several variant several variants severe COVID-19 shown South Africa Spike protein Stool Symptoms systemic inflammation the disease the spike protein tissue expression TMPRSS2 Transmissibility Transmission underlying disease underlying diseases variant variants variants of concern Viral viral entry viral genome Viral proteins Viremia virulence virus virus clearance VoC [DOI] 10.3389/fcimb.2021.753249 PMC 바로가기 [Article Type] Review
Generation of False-Positive SARS-CoV-2 Antigen Results with Testing Conditions outside Manufacturer Recommendations: A Scientific Approach to Pandemic MisinformationResearch Article Published on 2021-10-202022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] Abbott abrogated acute respiratory syndrome Ag-RDT Ag-RDTs antibodies antibody Antigen Anxiety buffer Care claimed clinical methods component condition conditions conducted conformational change coronavirus coronavirus disease country COVID-19 Critical demonstrated diagnostics Direct dissemination Epidemiology experiment extreme False positive False-positive False-positive results generate Generation Health help Interaction Laboratory mechanism media misinformation NaCl nonspecific occur offer PanBio Panbio assay pandemic positive control professionals proteinase public health Reactions recommendation recommendations reduce required resources Result resulting SARS-CoV-2 SARS-CoV-2 antigen shown specimen Support supported temperature tested Testing Treatment Tween 20 Virology while [DOI] 10.1128/Spectrum.00683-21 PMC 바로가기 [Article Type] Research Article
Generation and Effect Testing of a SARS-CoV-2 RBD-Targeted Polyclonal Therapeutic Antibody Based on a 2-D Airway Organoid Screening SystemImmunology Published on 2021-10-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome airway Airway organoids anti-RBD approved binding caused coronavirus Coronavirus disease 2019 COVID-19 develop domain Drug screening drugs Effect effective Efficacy Emergency use authorization epithelial Epitopes Ex vivo Generation immune in vivo Infection injection intrinsic morphology mouse model Mutation mutations Organoid polyclonal antibody Potential potential therapy Receptor-binding domain respiratory infectious disease Respiratory tract infections SARS-CoV-2 SARS-COV-2 infection Screening serum Side effect Side effects spread of COVID-19 System tested Testing tissue damage Treatment two-dimensional US FDA Vaccine viral escape viral infection viral neutralization viral strain virus [DOI] 10.3389/fimmu.2021.689065 PMC 바로가기 [Article Type] Immunology
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants수용체 결합 도메인과 N-말단 도메인 중화 항체의 조합은 SARS-CoV-2 스파이크 중화-도피 돌연변이의 생성을 제한합니다Research Article Published on 2021-10-052022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] analyzed antibody approved binding characterized Combination COVID-19 COVID-19 convalescent donor COVID-19 convalescent donors defined Effectiveness Efficacy Emergency use ENhance epitope Epitopes escape mutants FDA Generation hACE2 in vitro include inhibit less memory B-cell MOST mutant Mutation N-terminal domain NAb NAbs neutralization Neutralization assay neutralization assays neutralization potency NTD Protein RBD RBD-targeting nAbs Receptor-binding domain reduce reduced Region residue S protein SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS2 sera spike spike mutations stomatitis susceptible the RBD the receptor-binding domain therapy utility Vaccine variants variants of concern vesicular stomatitis vesicular stomatitis virus Viral viral infection VoC yeast [DOI] 10.1128/mBio.02473-21 PMC 바로가기 [Article Type] Research Article