Cellular metabolic basis of altered immunity in the lungs of patients with COVID-19Original Investigation Published on 2022-01-132023-06-15 Journal: Medical Microbiology and Immunology [Category] COVID19(2023년), MERS, SARS, [키워드] cellular metabolism COVID-19 Glycolysis host immunity RNA sequencing [DOI] 10.1007/s00430-021-00727-0 PMC 바로가기 [Article Type] Original Investigation
Cultivation of Cells in a Physiological Plasmax Medium Increases Mitochondrial Respiratory Capacity and Reduces Replication Levels of RNA VirusesArticle Published on 2021-12-302022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] blood plasma Cancer Capacity Cell change concerning coronavirus cultivation culture medium cultured cells dysregulated ENhance event Glycolysis HCV hepatitis C virus Human plasma IAV identification increase Inflammatory diseases influenza A virus Influenza virus Intervention less Level lysosome Lysosomes mammalian cell media medium metabolic pathway metabolism metabolite mitochondrial mitochondrial network obesity pathology performed Plasmax reactive oxygen species reactive oxygen specy Replication Respiration respiratory RNA RNA viruses ROS SARS-CoV-2 serine biosynthesis significantly standard media Support syndrome two group viral infections were used [DOI] 10.3390/antiox11010097 PMC 바로가기 [Article Type] Article
Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDSResearch Published on 2021-11-152022-11-01 Journal: Critical Care [Category] COVID-19, MERS, 신종인플루엔자, [키워드] alteration Amino acid Analysis analyzed ARDS Biomarker cause characteristic characterized Conference Coronavirus disease 2019 COVID-19 COVID‐19 defined Diagnosis distress etiologies Glycolysis groups H1N1 influenza identify induce Inflammatory intensive care involved lipid metabolism Lung inflammation maintain management metabolic pathway metabolism metabolomic metabolomics multivariate NMR noradrenaline oxidative stress pathway Pathways Patient patients with ARDS patients with COVID-19 Pneumonia Prognosis Pulmonary edema Regulation resonance Respiratory failure responses Result serum sample severe cases specificity Spectroscopy supplementary material Support syndrome was performed were used [DOI] 10.1186/s13054-021-03810-3 PMC 바로가기 [Article Type] Research
Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1Immunology Published on 2021-11-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 2-deoxyglucose 2-DG binding blocked COVID-19 cytokine cytokine production dependent on Deprivation direct infection dose-dependent drug experiments Glucose Glycolysis hallmark hyperinflammation hyperinflammatory state immunometabolism implication increase in induce Inflammation Inflammatory cytokine Inflammatory response inhibit inhibited inhibition live SARS-CoV-2 metabolism metformin mitochondrial metabolism monocyte oxidative phosphorylation pro-inflammatory pro-inflammatory cytokines regulate rescued SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 strain severity spike Spike protein stimulated subunit suppresse suppressed the SARS-CoV-2 Treatment undergo upregulating viral spike protein WA1/2020 [DOI] 10.3389/fimmu.2021.733921 PMC 바로가기 [Article Type] Immunology
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection기도 오르가노이드 기반 스크린은 SARS-CoV-2 감염에서 HIF1α-해당 축의 역할을 식별합니다Article Published on 2021-10-152022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 2-furoic acid Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway airway organoid Alpha Analysis Anti-viral drugs B.1.351 block cells Chemical Compound coronavirus develop Disease model disease models dissect fatty Fatty acid fatty acid synthesis Genetic Glycolysis GW4671 high content drug screen hPSC-derived colonic organoid hPSC-derived colonic organoids human airway Human airway epithelium hypoxia hypoxia-inducible factor 1-alpha identify Infection inhibiting inhibitor mechanism metabolic MONITOR Organoid platform pluripotent stem cell respiratory reveal RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Screen severe acute respiratory syndrome Coronavirus stem cells subunit suppress Transcriptome Treatment xanthohumol [DOI] 10.1016/j.celrep.2021.109920 PMC 바로가기 [Article Type] Article
Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral TargetsReview Published on 2021-10-142022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Adenovirus AdV benefit cellular common Compound coronavirus CoV fatty function Glycolysis highlight host cell host targeted antivirals humans include Influenza virus knowledge Lung infection metabolic metabolic pathway metabolism Modification New parainfluenza virus pathway Potential Replication respiratory respiratory syncytial virus respiratory virus respiratory viruses rhinovirus RSV Signaling target therapeutic approaches viral infections virus [DOI] 10.3390/v13102068 PMC 바로가기 [Article Type] Review
Targeting the Pentose Phosphate Pathway for SARS-CoV-2 TherapyArticle Published on 2021-10-132022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] 2-deoxy-d-glucose addition Analysis Anti-SARS-CoV-2 Activity Antiviral antiviral therapy benfooxythiamine Bot changes in coronavirus disease COVID-19 COVID-19 patients effective generate Glycolysis host cell metabolism Immune cell immunomodulatory effects immunopathology IMPROVE indicated induce inhibited inhibiting inhibitor interfere metabolic drug metabolism outcome oxythiamine pandemic pathway pentose pentose phosphate pathway pharmacological proteomics data Regulation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2-infected cells targeting therapy TKT Treatment [DOI] 10.3390/metabo11100699 PMC 바로가기 [Article Type] Article
Salmonella enterica Serovar Typhi Induces Host Metabolic Reprogramming to Increase Glucose Availability for Intracellular Replication살모넬라 엔테리카 세로바르 타이피는 세포 내 복제를 위한 포도당 가용성을 증가시키기 위해 숙주 대사 재프로그래밍을 유도한다.Article Published on 2021-09-162024-07-29 Journal: International Journal of Molecular Sciences [Category] 살모넬라증, [키워드] glucose utilization Glycolysis intracellular replication Pathogenesis S. Typhi [DOI] 10.3390/ijms221810003 PMC 바로가기 [Article Type] Article
Targeting Host Glycolysis as a Strategy for Antimalarial Development말라리아 치료제 개발을 위한 전략으로서 숙주 해당작용 표적화Original Research Published on 2021-09-162024-08-08 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] antimalarial Enolase erythrocyte Glycolysis malaria oxidative stress Plasmodium red blood cells [DOI] 10.3389/fcimb.2021.730413 PMC 바로가기 [Article Type] Original Research
Influenza A Virus (H1N1) Infection Induces Glycolysis to Facilitate Viral ReplicationResearch Article Published on 2021-09-142023-06-08 Journal: Virologica Sinica [Category] Fulltext, 신종인플루엔자, [키워드] Glycolysis H1N1 Hypoxia-inducible factor 1 (HIF-1) interferon Replication [DOI] 10.1007/s12250-021-00433-4 PMC 바로가기 [Article Type] Research Article