Risk factors associated with day-30 mortality in patients over 60 years old admitted in ICU for severe COVID-19: the Senior-COVID-Rea Multicentre Survey protocolArticle Published on 2021-07-062022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] Admission age ambition Analysis approach approved assist C-reactive protein Care carried clinician conducted Course COVID-19 COVID-19 infection creatinine criteria Critical care CT scan Epidemic Ethics evaluate extension Factor frailty France functional geriatric medicine granulocyte Health hospital ICU ICU admission ICUs immature Infection Intensive intensive & intensive care unit lactate dehydrogenase LDH Logistic regression logistic regressions lung lymphocyte lymphoid cell Mortality multicentre multivariate neutrophil nutritional parameter Older age outcomes parameter Patient patients with COVID-19 peer-reviewed percentage predict Primary outcome protocol questionnaire Seven severe COVID-19 disease Severe COVID-19 Infection spread of COVID-19 Study protocol survey survival to define Trial [DOI] 10.1136/bmjopen-2020-044449 PMC 바로가기 [Article Type] Article
Emerging Evidence for Pleiotropism of EosinophilsReview Published on 2021-06-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome allergies Asthma Bacteria biologic treatment Blood Bone marrow complex coronavirus SARS-CoV-2 described detrimental Developing disease disorder effective response effector enzymatic activity eosinophil eosinophil extracellular traps eosinophils esophagitis example Exosome extracellular DNA Factors function gastrointestinal tract GM-CSF granulocyte homeostasis human physiology IL-5 immune immune defense immune responses Immunity involved liver lung Macrophage mammary mechanism monoclonal antibody organ organs parasites Pathologies pathophysiologic pleiotropic Pleiotropism regulatory cell respond Skeletal muscle specific treatment sub-phenotypes surface receptors sustained these cell tissue homeostasis Treatment viral pathogen [DOI] 10.3390/ijms22137075 PMC 바로가기 [Article Type] Review
The Role of Th17 Response in COVID-19Review Published on 2021-06-192022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] activating acute infectious disease cascade caused colony stimulating factor coronavirus 2 counterproductive Course COVID-19 COVID-19 pneumonia cytokine Cytokines Defense droplet Evidence G-CSF granulocyte hospitalised IL-10 IL-17 IL-2 IL-6 IL-7 IL-8 ill patient immune response immune system Increasing Infection inhibiting interleukin MCP-1 monocyte Necrosis occur pathogenesis of COVID-19 Protein respiratory Respiratory system response role SARS-CoV-2 SARS-COV-2 infection target Th1 Th17 Th17 cell Th17 pathway Th17 response Th2 responses the SARS-CoV-2 virus therapeutic intervention TNF Treg cells viral infection with COVID-19 [DOI] 10.3390/cells10061550 PMC 바로가기 [Article Type] Review
Circulating Cytokines and Coronavirus Disease: A Bi-Directional Mendelian Randomization StudyGenetics Published on 2021-06-072022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] 95% CI 95% confidence interval affected CCL4 conducted controls coronavirus disease COVID-19 cytokine Cytokines estimates GCSF genetic risk genetics Genome-wide association studies granulocyte hepatocyte growth factor HGF Hospitalized hospitalized COVID-19 immune response immune system Immunity Infection Inflammatory Intervention IVW Laboratory Ligand mendelian randomization motif multiple comparisons Prevent replicated Result risk sensitivity analysis was related Weighting with COVID-19 [DOI] 10.3389/fgene.2021.680646 PMC 바로가기 [Article Type] Genetics
Evaluation of hematological parameters as an indicator of disease severity in Covid‐19 patients: Pakistan’s experienceCovid-19 환자의 질병 중증도 지표로서의 혈액학적 매개변수 평가: 파키스탄의 경험Observational Study Published on 2021-05-242022-09-10 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, 바이오마커, 임상, 진단, [키워드] age alteration association Biomarker Biomarkers Blood blood cell Cell clinician conducted COVID‐19 COVID‐19 patients COVID‐19 Critical critical patients death disease severity distribution early stages effective Elevation evaluated Evaluating granulocyte Granulocytes hematological parameter hematological parameters identify Indicator individual lymphocyte Lymphocytes management marker methodology Mild mild patient mild patients moderate monocyte Mortality neutrophil Neutrophils NLR overall mortality p value parameter Patient patients Platelet Platelet count positive patient Prognosis recorded red blood cell reduce Result Severe case severe cases severity significantly increased the disease the mean Volume WBC White blood cell [DOI] 10.1002/jcla.23809 PMC 바로가기 [Article Type] Observational Study
Giloy Ghanvati ( Tinospora cordifolia (Willd.) Hook. f. and Thomson) Reversed SARS-CoV-2 Viral Spike-Protein Induced Disease Phenotype in the Xenotransplant Model of Humanized ZebrafishPharmacology Published on 2021-04-192022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] A549 artificial ventilation ayurved Ayurveda caused changes in comparable correlated cough disease disease phenotype distress dosage epithelial cell feature Fever giloy ghanvati granulocyte healthcare Hook human lung humanized Immune cell induced Infection infiltration inflamation Inflammation lack Macrophage Model phenotype pro-inflammatory renal tissue reported respiratory reversed SARS-CoV-2 SARS–CoV–2 spike-protein swim bladder symptomatic systemic damage targeted therapy the disease the SARS-CoV-2 therapy tinopsora cordifolia Traditional Treatment treatment group viral disease were given xenotranplantation zebrafish [DOI] 10.3389/fphar.2021.635510 PMC 바로가기 [Article Type] Pharmacology
Janus kinase signaling as risk factor and therapeutic target for severe SARS‐CoV‐2 infectionMini‐Review|Clinical Published on 2021-03-222022-10-31 Journal: European Journal of Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Affect antiviral immune responses antiviral responses association Baricitinib cellular entry receptor chemokine coronavirus COVID‐19 COVID‐19 patient COVID‐19 patients Critically ill cytokine cytokine signaling Cytokine storm develop disease drug Effect endothelial cells epithelial explain Genetic polymorphism granulocyte help IFN IFN‐γ IL‐6 immunological Infection Inflammation inflammatory mediator initial interferon Jak JAK inhibitor jak inhibitors JAK/STAT pathway JAK/STAT signaling pathway Janus kinase knowledge locus lung lung tissue Macrophage macrophages neutrophil Patient patients Prevent receptor reduce regulate reported risk factor SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2 severe Covid‐19 severe disease Signaling symptomatic patient T helper target cells the disease therapeutic target TYK2 viral endocytosis virus replication [DOI] 10.1002/eji.202149173 PMC 바로가기 [Article Type] Mini‐Review|Clinical
A neutrophil activation signature predicts critical illness and mortality in COVID-19호중구 활성화 시그니처는 COVID-19의 심각한 질병 및 사망률을 예측합니다Article Published on 2021-03-092022-09-11 Journal: Blood advances [Category] SARS, 바이오마커, [키워드] Algorithm analyzed carried Clinical data clinical decompensation Cohort colony-stimulating factor COVID-19 Critical Critical illness cross-sectional database decompensation early elevations Elevation evidence of granulocyte granulocyte colony-stimulating factor health system hepatocyte growth factor Hospitalization hospitalized patient hospitalized patients Hyperactivation identify immune increased mortality intensive care intensive care unit interleukin interleukin-8 involved lipocalin-2 marker mechanism molecular molecular markers Mortality mortality rates neutrophil neutrophil activation neutrophil count Pathogenesis Patient patients plasma predict predicted predictor proteomic resistin risk severe COVID-19 the strongest These data transfer with COVID-19 [DOI] 10.1182/bloodadvances.2020003568 PMC 바로가기 [Article Type] Article
Heterogeneous NLRP3 inflammasome signature in circulating myeloid cells as a biomarker of COVID-19 severityCOVID-19 중증도의 바이오마커로서 순환하는 골수 세포의 이종 NLRP3 인플라마좀 시그니처Article Published on 2021-03-092022-09-11 Journal: Blood advances [Category] SARS, 바이오마커, [키워드] Activation acute respiratory syndrome Biomarker Blood caspase caspase-1 CD66b Cell circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity Critical critical COVID-19 patients dysregulated immune response eosinophil eosinophils Evolution granulocyte Granulocytes healthy donor healthy donors immature neutrophil immune response Infection Innate immunity key factor Mild monocyte Monocytes myeloid cell myeloid cells Neutrophils nigericin NLRP3 NLRP3 inflammasome outcome pathogen pathogen-associated molecular Patient predict proportion Registered respiratory restored severe acute respiratory syndrome Coronavirus Trial [DOI] 10.1182/bloodadvances.2020003918 PMC 바로가기 [Article Type] Article
Recovery of Innate Immune Cells and Persisting Alterations in Adaptive Immunity in the Peripheral Blood of Convalescent Plasma Donors at Eight Months Post SARS-CoV-2 InfectionArticle Published on 2021-03-062022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 8 months adaptive alteration Analysis B cell CD11b CD8+ Cell changes in characterized component convalescence plasma donors convalescent plasma COVID-19 COVID-19 infection Donor donors eight flow cytometry granulocyte immune immune profiling immune restoration immune signature Immunity Infection initial Innate Innate immunity Intermediate monocyte median time Month natural killer NKT Non-classical monocytes notable peripheral Peripheral blood post infection reduction remained restored SARS-CoV-2 SARS-COV-2 infection skewed subset Th1 Th2 Treg unique Variation [DOI] 10.3390/microorganisms9030546 PMC 바로가기 [Article Type] Article